UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 1)*


                         Biospecifics Technologies Corp.
                         -------------------------------
                                (Name of Issuer)


                          Common Stock, $.001 par value
                         -------------------------------
                         (Title of Class of Securities)


                                    090931106
                             ----------------------
                                 (CUSIP Number)


                                Jeffrey K. Vogel
                                 Bio Partners LP
                                 1 Meadow Drive
                            Lawrence, New York 11559
                            Telephone: (516) 295-1762
          ------------------------------------------------------------
          (Name, Address and Telephone Number of Persons Authorized to
                       Receive Notices and Communications)


                                October 24, 2005
             -------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


         Check the appropriate box to designate the rule pursuant to which this
         is filed:

         [ ]  Rule 13d-1(b)
         [X]  Rule 13d-1(c)
         [ ]  Rule 13d-1(d)

         *  The remainder of this cover page shall be filled out for a reporting
         person's initial filing on this form with respect to the subject class
         of securities, and for any subsequent amendment containing information
         which would alter disclosures provided in a prior cover page.

         The information required on the remainder of this cover page shall not
         be deemed to be "filed" for the purpose of Section 18 of the Securities
         Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
         that section of the Act but shall be subject to all other provisions of
         the Act (however, see the Notes).


                                  SCHEDULE 13G
--------------------------------------------------------------------------------
CUSIP No. 090931106                                           Page 2 of 10 Pages
--------------------------------------------------------------------------------
1    NAME OF REPORTING PERSON:           Bio Partners LP
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: [___________________]

--------------------------------------------------------------------------------
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                       (a) [X]
                                                                       (b) [ ]
--------------------------------------------------------------------------------
3    SEC USE ONLY
--------------------------------------------------------------------------------
4    CITIZENSHIP OR PLACE OR ORGANIZATION        

     Delaware
--------------------------------------------------------------------------------

NUMBER OF SHARES                    5    SOLE VOTING POWER          0
BENEFICIALLY OWNED                  --------------------------------------------
BY EACH REPORTING                   6    SHARED VOTING POWER        289,500(1)
PERSON WITH                         --------------------------------------------
                                    7    SOLE DISPOSITIVE POWER     0
                                    --------------------------------------------
                                    8    SHARED DISPOSITIVE POWER   289,500(1)
--------------------------------------------------------------------------------
9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

     289,500(1)
--------------------------------------------------------------------------------
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
     (See Instructions)         

     N/A
--------------------------------------------------------------------------------
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)             
  
     5.44% (2)
--------------------------------------------------------------------------------
12   TYPE OF REPORTING PERSON  (See Instructions)         

     PN
--------------------------------------------------------------------------------

(1)  Bio Partners LP, a Delaware limited partnership, has a sole general
     partner, Bio Management, Inc., a New York corporation ("Bio Management"),
     and Bio Management's sole shareholder and President is Jeffrey K. Vogel.
     Mr. Vogel thus has the power to vote or dispose of the 289,500 shares of
     common stock, $.001 par value ("Common Stock") of Biospecifics Technologies
     Corp. ("Biospecifics") owned by Bio Partners LP.
(2)  Calculated based on 5,326,341 shares of Biospecifics Technologies Corp.'s
     Common Stock outstanding as of November 1, 2004, as reported in its annual
     report on Form 10-KSB/A for the year ended December 31, 2003 and filed with
     the Securities and Exchange Commission on December 2, 2004.

                                       2


                                  SCHEDULE 13G
--------------------------------------------------------------------------------
CUSIP No. 090931106                                           Page 3 of 10 Pages
--------------------------------------------------------------------------------
1    NAME OF REPORTING PERSON:           Jeffrey K. Vogel
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: [___________________]

--------------------------------------------------------------------------------
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                       (a) [X]
                                                                       (b) [ ]
--------------------------------------------------------------------------------
3    SEC USE ONLY
--------------------------------------------------------------------------------
4    CITIZENSHIP OR PLACE OR ORGANIZATION        

     United States
--------------------------------------------------------------------------------

NUMBER OF SHARES                    5    SOLE VOTING POWER          56,136
BENEFICIALLY OWNED                  --------------------------------------------
BY EACH REPORTING                   6    SHARED VOTING POWER        289,500(1)
PERSON WITH                         --------------------------------------------
                                    7    SOLE DISPOSITIVE POWER     56,136
                                    --------------------------------------------
                                    8    SHARED DISPOSITIVE POWER   400,474(2)
--------------------------------------------------------------------------------
9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  
     
     456,620(3)
--------------------------------------------------------------------------------
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
     (See Instructions)         
  
     N/A
--------------------------------------------------------------------------------
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)             

     8.57% (4)
--------------------------------------------------------------------------------
12   TYPE OF REPORTING PERSON  (See Instructions)         
   
     IN
--------------------------------------------------------------------------------

(1)  Mr. Vogel is the sole shareholder and President of Bio Management, which is
     the sole general partner of Bio Partners LP. Mr. Vogel thus has the power
     to vote these 289,500 shares of Common Stock owned by Bio Partners LP. 
(2)  Mr. Vogel is the sole shareholder and President of Bio Management, which is
     the sole general partner of Bio Partners LP. Mr. Vogel thus has the power
     to dispose these 289,500 shares of Common Stock owned by Bio Partners LP.
     In addition, Mr. Vogel has the power to dispose of 56,556 shares of Common
     Stock owned by his brother Jon M. Vogel and 54,418 shares of Common Stock
     owned by his father Sherman C. Vogel.
(3)  Includes (i) 56,136 shares of Common Stock held directly by Jeffrey K.
     Vogel, (ii) 289,500 shares of Common Stock held by Bio Partners LP, (iii)
     56,566 shares of Common Stock held by his brother Jon M. Vogel and (iv)
     54,418 shares of Common Stock held by Sherman C. Vogel.
(4)  Calculated based on 5,326,341 shares of Biospecifics Technologies Corp.'s
     Common Stock outstanding as of November 1, 2004, as reported in its annual
     report on Form 10-KSB/A for the year ended December 31, 2003 and filed with
     the Securities and Exchange Commission on December 2, 2004.

                                       3


                                  SCHEDULE 13G
--------------------------------------------------------------------------------
CUSIP No. 090931106                                           Page 4 of 10 Pages
--------------------------------------------------------------------------------
1    NAME OF REPORTING PERSON:           Jon M. Vogel
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: [___________________]

--------------------------------------------------------------------------------
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                       (a) [X]
                                                                       (b) [ ]
--------------------------------------------------------------------------------
3    SEC USE ONLY
--------------------------------------------------------------------------------
4    CITIZENSHIP OR PLACE OR ORGANIZATION        

     United States
--------------------------------------------------------------------------------

NUMBER OF SHARES                    5    SOLE VOTING POWER          56,566
BENEFICIALLY OWNED                  --------------------------------------------
BY EACH REPORTING                   6    SHARED VOTING POWER        0
PERSON WITH                         --------------------------------------------
                                    7    SOLE DISPOSITIVE POWER     0
                                    --------------------------------------------
                                    8    SHARED DISPOSITIVE POWER   56,566(1)
--------------------------------------------------------------------------------
9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

     56,566
--------------------------------------------------------------------------------
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
     (See Instructions)        

     N/A
--------------------------------------------------------------------------------
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)             

     1.06% (2)
--------------------------------------------------------------------------------
12   TYPE OF REPORTING PERSON  (See Instructions)        

     IN
--------------------------------------------------------------------------------

(1)  Jeffrey K. Vogel has the power to dispose of 56,566 shares of Common Stock
     owned by his brother Jon M. Vogel.
(2)  Calculated based on 5,326,341 shares of Biospecifics Technologies Corp.'s
     Common Stock outstanding as of November 1, 2004, as reported in its annual
     report on Form 10-KSB/A for the year ended December 31, 2003 and filed with
     the Securities and Exchange Commission on December 2, 2004.

                                       4


                                  SCHEDULE 13G
--------------------------------------------------------------------------------
CUSIP No. 090931106                                           Page 5 of 10 Pages
--------------------------------------------------------------------------------
1    NAME OF REPORTING PERSON:           Sherman C. Vogel
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON: [___________________]

--------------------------------------------------------------------------------
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                       (a) [X]
                                                                       (b) [ ]
--------------------------------------------------------------------------------
3    SEC USE ONLY
--------------------------------------------------------------------------------
4    CITIZENSHIP OR PLACE OR ORGANIZATION        

     United States
--------------------------------------------------------------------------------

NUMBER OF SHARES                    5    SOLE VOTING POWER          54,418
BENEFICIALLY OWNED                  --------------------------------------------
BY EACH REPORTING                   6    SHARED VOTING POWER        0
PERSON WITH                         --------------------------------------------
                                    7    SOLE DISPOSITIVE POWER     0
                                    --------------------------------------------
                                    8    SHARED DISPOSITIVE POWER   54,418(1)
--------------------------------------------------------------------------------
9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  

     54,418
--------------------------------------------------------------------------------
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
     (See Instructions)         

     N/A
--------------------------------------------------------------------------------
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)             

     1.02% (2)
--------------------------------------------------------------------------------
12   TYPE OF REPORTING PERSON  (See Instructions)         

     IN
--------------------------------------------------------------------------------

(1)  Jeffrey K. Vogel has the power to dispose of 54,418 shares of Common Stock
     owned by his father Sherman Vogel. 
(2)  Calculated based on 5,326,341 shares of Biospecifics Technologies Corp.'s
     Common Stock outstanding as of November 1, 2004, as reported in its annual
     report on Form 10-KSB/A for the year ended December 31, 2003 and filed with
     the Securities and Exchange Commission on December 2, 2004.

                                       5


Item 1.
         (a)  Name of Issuer:
              --------------
  
              Biospecifics Technologies Corp. ("Biospecifics")

         (b)  Address of Issuer's Principal Executive Offices:
              -----------------------------------------------

              35 Wilbur Street, Lynbrook, New York   11563

Item 2.
         (a)  Name of Persons Filing:
              ----------------------

              Bio Partners LP

              Jeffrey K. Vogel

              Jon M. Vogel

              Sherman C. Vogel

         (b)  Address of Principal Business Office or, if none, Residence:
              -----------------------------------------------------------

              (i) The address of each Bio Partners LP and Jeffrey K. Vogel is:

              1 Meadow Drive

              Lawrence, NY 11559

              (ii) The address of Jon M. Vogel is:

              17020 Brookwood Drive

              Boca Raton, FL 33496

              (iii) The address of Sherman C. Vogel is:

              7110 Melrose Castle Lane

              Boca Raton, FL 33496

         (c)  Citizenship:
              -----------

              Bio Partners LP is a Delaware limited partnership.

              Jeffrey K. Vogel, Jon M. Vogel and Sherman C. Vogel are each a
              citizen of the United States.

         (d)  Title of Class of Securities:
              ----------------------------
  
              Common Stock, par value $.001 per share (the "Common Stock")

         (e)  CUSIP Number: 090931106
              -----------------------
Item 3.

         This statement is not being filed pursuant to Rule 13d-1(b), or
13d-2(b) or (c).

                                       6


Item 4.  Ownership

         (a)  Amount beneficially owned:
              -------------------------

         Bio Partners LP beneficially owns 289,500 shares of Biospecifics'
Common Stock, which does not include 400,000 shares of Common Stock issuable
upon the conversion of a 12% Senior Convertible Note from Biospecifics ("Note"),
as previously reported on Schedule 13G. The Note is no longer outstanding and
the option of convert the aggregate principal amount of such Note to shares of
Common Stock has expired.

         Jeffrey K. Vogel beneficially owns 456,620 shares of Biospecifics'
Common Stock, which includes (i) 56,136 shares of Common Stock held directly by
Jeffrey K. Vogel, (ii) 289,500 shares of Common Stock held by Bio Partners LP,
(iii) 56,566 shares of Common Stock held by his brother Jon M. Vogel and (iv)
54,418 shares of Common Stock held by father Sherman C. Vogel.

         Jon M. Vogel beneficially owns 56,566 shares of Biospecifics' Common
Stock.

         Sherman C. Vogel beneficially owns 54,418 shares of Biospecifics'
Common Stock.

         Together, the reporting persons beneficially own 456,620 shares of
Biospecifics' Common Stock.

         (b)  Percent of class:
              ----------------
  
         Calculated based on 5,326,341 shares of Biospecifics Technologies
Corp.'s Common Stock outstanding as of November 1, 2004, as reported in its
annual report on Form 10-KSB/A for the year ended December 31, 2003 and filed
with the Securities and Exchange Commission on December 2, 2004.

         Bio Partners LP has beneficial ownership of 5.44% of all of the
outstanding shares of Biospecifics' Common Stock.

         Jeffrey K. Vogel has beneficial ownership of 8.57% of all of the
outstanding shares of Biospecifics' Common Stock.

         Jon M. Vogel has beneficial ownership of 1.06% of all of the
outstanding shares of Biospecifics' Common Stock.

         Sherman C. Vogel has beneficial ownership of 1.02% of all of the
outstanding shares of Biospecifics' Common Stock.

         Together, the reporting persons have beneficial ownership of 8.57%
percent of all of the outstanding shares of Biospecifics' Common Stock.

                                       7


         (c)  Number of shares as to which the person has:
              -------------------------------------------

              (i)   Sole power to vote or to direct the vote:
                    ----------------------------------------

              Bio Partners LP has the sole power to vote or direct the vote of 0
shares of Biospecifics' Common Stock.

              Jeffrey K. Vogel has the sole power to vote or direct the vote of
56,136 shares of Biospecifics' Common Stock.

              Jon M. Vogel has the sole power to vote or direct the vote of
56,566 shares of Biospecifics' Common Stock.

              Sherman C. Vogel has the sole power to vote or direct the vote of
54,418 shares of Biospecifics' Common Stock.

              (ii)  Shared power to vote or to direct the vote:
                    ------------------------------------------

              Bio Partners LP has shared power to vote or direct the vote of
289,500 shares of Biospecifics' Common Stock. Jeffrey K. Vogel is the sole
shareholder and President of Bio Management, Inc., a New York corporation ("Bio
Management"), which is the sole general partner of Bio Partners LP. Mr. Vogel
thus has the power to vote or dispose of the 289,500 shares of specifics' Common
Stock owned by Bio Partners LP.

              Jeffrey K. Vogel has shared power to vote or direct the vote of
289,500 shares of Biospecifics' Common Stock with Bio Partners LP.

              Jon M. Vogel has shared power to vote or direct the vote of 0
shares of Biospecifics' Common Stock.

              Sherman C. Vogel has shared power to vote or direct the vote of 0
shares of Biospecifics' Common Stock.

              (iii) Sole power to dispose or to direct the disposition of:
                    -----------------------------------------------------

              Bio Partners LP has the sole power to dispose or direct the
disposition of 0 shares of Biospecifics' Common Stock.

              Jeffrey K. Vogel has the sole power to dispose or direct the
disposition of 56,136 shares of Biospecifics' Common Stock.

              Jon M. Vogel has the sole power to dispose or direct the
disposition of 0 shares of Biospecifics' Common Stock.

              Sherman C. Vogel has the sole power to dispose or direct the
disposition of 0 shares of Biospecifics' Common Stock.

                                       8


              (iv)  Shared power to dispose or to direct the disposition of:
                    -------------------------------------------------------

              Bio Partners LP has the shared power to dispose or direct the
disposition of 289,500 shares of Biospecifics' Common Stock. Jeffrey K. Vogel is
the sole shareholder and President of Bio Management, the sole general partner
of Bio Partners LP. Mr. Vogel thus has the power to vote or dispose of the
289,500 shares of Common Stock owned by Bio Partners LP.

              Jeffrey K. Vogel has the shared power to dispose or direct the
disposition of 400,474 shares of Biospecifics' Common Stock which includes (i)
289,500 shares of Common Stock owned by Bio Partners LP, (ii) 56,556 shares of
Common Stock owned by his brother Jon M. Vogel and (iii) 54,418 shares of Common
Stock owned by his father Sherman C. Vogel.

              Jon M. Vogel has the shared power to dispose or direct the
disposition of 56,566 shares of Biospecifics' Common Stock with his brother
Jeffrey K. Vogel.

              Sherman C. Vogel has the shared power to dispose or direct the
disposition of 54,418 shares of Biospecifics' Common Stock with his son Jeffrey
K. Vogel.

Item 5.  Ownership of Five Percent or Less of a Class

         Not Applicable.

Item 6.  Ownership of More than Five Percent on Behalf of Another Person.

         Not applicable.

Item 7.  Identification and Classification of the Subsidiary Which Acquired the
         Security Being Reported on By the Parent Holding Company or Control
         Person

         Not applicable.

Item 8.  Identification and Classification of Members of the Group

         Not Applicable

Item 9.  Notice of Dissolution of Group

         Not Applicable

         Item 10. Certification

         (b)  This Schedule 13G Amendment is being filed pursuant to Rule
13d-1(c):

         By signing below we certify that, to the best of our knowledge and
belief, the securities referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.

                                       9


                                    SIGNATURE

         After reasonable inquiry and to the best of each undersigned's
knowledge and belief, the undersigned hereby certify that the information set
forth in this Statement is true, complete and correct.

October 25, 2005


                                       BIO PARTNERS LP

                                       By: Bio Management, Inc., its sole
                                           general partner

                                       By: /s/ JEFFREY K. VOGEL 
                                           -------------------------------------
                                           Name:  Jeffrey K. Vogel
                                           Title: President


                                       By: /s/ JEFFREY K. VOGEL 
                                           -------------------------------------
                                           Jeffrey K. Vogel


                                       By: /s/ JON M. VOGEL              
                                           -------------------------------------
                                           Jon M. Vogel


                                       By: /s/ SHERMAN C. VOGEL 
                                           -------------------------------------
                                           Sherman C. Vogel


                                       10


                                    EXHIBIT A

                             JOINT FILING AGREEMENT


         The undersigned agree that this Amendment No. 1 to Schedule 13G filed
herewith relating to the shares of common stock of Biospecifics Technogies Corp.
is filed jointly on behalf of each of the undersigned pursuant to Rule 13d-1(k)
under the Exchange Act.


October 25, 2005


                                       BIO PARTNERS LP

                                       By: Bio Management, Inc., its sole
                                           general partner

                                       By: /s/ JEFFREY K. VOGEL 
                                           -------------------------------------
                                           Name:  Jeffrey K. Vogel
                                           Title: President


                                       By: /s/ JEFFREY K. VOGEL 
                                           -------------------------------------
                                           Jeffrey K. Vogel


                                       By: /s/ JON M. VOGEL              
                                           -------------------------------------
                                           Jon M. Vogel


                                       By: /s/ SHERMAN C. VOGEL 
                                           -------------------------------------
                                           Sherman C. Vogel