UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*


                         BioSpecifics Technologies Corp.
             -------------------------------------------------------
                                (Name of Issuer)


                         Common Stock, $0.001 par value
             -------------------------------------------------------
                         (Title of Class of Securities)


                                    090931106
             -------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 2008
             -------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ] Rule 13d-1(b)

[X] Rule 13d-1(c)

[ ] Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                               Page 1 of 13 Pages



CUSIP No. 090931106

1.    Names of Reporting Persons
      I.R.S. Identification Nos. of above persons (entities only)

      Steven A. Werber, Jr.

2.    Check the Appropriate Box if a Member of a Group (See Instructions)

      (a) [ ]
      (b) [X]

3.    SEC Use Only

4.    Citizenship or Place of Organization

      United States

NUMBER OF          5. SOLE VOTING POWER                                       0
SHARES
BENEFICIALLY       6. SHARED VOTING POWER                               227,514
OWNED BY EACH
REPORTING          7. SOLE DISPOSITIVE POWER                                  0
PERSON WITH:
                   8. SHARED DISPOSITIVE POWER                          227,514

9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      227,514

10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions) [ ]

11.   Percent of Class Represented by Amount in Row (9)

      3.8%

12.   Type of Reporting Person (See Instructions)

      IN

                               Page 2 of 13 Pages



CUSIP No. 090931106

1.    Names of Reporting Persons
      I.R.S. Identification Nos. of above persons (entities only)

      Daniel J. Barker

2.    Check the Appropriate Box if a Member of a Group (See Instructions)

      (a) [ ]
      (b) [X]

3.    SEC Use Only

4.    Citizenship or Place of Organization

      United States

NUMBER OF          5. SOLE VOTING POWER                                   3,800
SHARES
BENEFICIALLY       6. SHARED VOTING POWER                               227,514
OWNED BY EACH
REPORTING          7. SOLE DISPOSITIVE POWER                              3,800
PERSON WITH:
                   8. SHARED DISPOSITIVE POWER                          227,514

9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      231,314

10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions) [ ]

11.   Percent of Class Represented by Amount in Row (9)

      3.9%

12.   Type of Reporting Person (See Instructions)

      IN

                               Page 3 of 13 Pages



CUSIP No. 090931106

1.    Names of Reporting Persons
      I.R.S. Identification Nos. of above persons (entities only)

      Apis Capital Advisors, LLC

2.    Check the Appropriate Box if a Member of a Group (See Instructions)

      (a) [ ]
      (b) [X]

3.    SEC Use Only

4.    Citizenship or Place of Organization

      Delaware

NUMBER OF          5. SOLE VOTING POWER                                       0
SHARES
BENEFICIALLY       6. SHARED VOTING POWER                               227,514
OWNED BY EACH
REPORTING          7. SOLE DISPOSITIVE POWER                                  0
PERSON WITH:
                   8. SHARED DISPOSITIVE POWER                          227,514

9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      227,514

10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions) [ ]

11.   Percent of Class Represented by Amount in Row (9)

      3.8%

12.   Type of Reporting Person (See Instructions)

      IA

                               Page 4 of 13 Pages



CUSIP No. 090931106

1.    Names of Reporting Persons
      I.R.S. Identification Nos. of above persons (entities only)

      Apis Capital, LP

2.    Check the Appropriate Box if a Member of a Group (See Instructions)

      (a) [ ]
      (b) [X]

3.    SEC Use Only

4.    Citizenship or Place of Organization

      Delaware

NUMBER OF          5. SOLE VOTING POWER                                      0
SHARES
BENEFICIALLY       6. SHARED VOTING POWER                               17,910
OWNED BY EACH
REPORTING          7. SOLE DISPOSITIVE POWER                                 0
PERSON WITH:
                   8. SHARED DISPOSITIVE POWER                          17,910

9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      17,910

10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions) [ ]

11.   Percent of Class Represented by Amount in Row (9)

      0.3%

12.   Type of Reporting Person (See Instructions)

      PN

                               Page 5 of 13 Pages



CUSIP No. 090931106

1.    Names of Reporting Persons
      I.R.S. Identification Nos. of above persons (entities only)

      Apis Capital (QP), LP

2.    Check the Appropriate Box if a Member of a Group (See Instructions)

      (a) [ ]
      (b) [X]

3.    SEC Use Only

4.    Citizenship or Place of Organization

      Delaware

NUMBER OF          5. SOLE VOTING POWER                                       0
SHARES
BENEFICIALLY       6. SHARED VOTING POWER                                22,992
OWNED BY EACH
REPORTING          7. SOLE DISPOSITIVE POWER                                  0
PERSON WITH:
                   8. SHARED DISPOSITIVE POWER                           22,992

9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      22,992

10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions) [ ]

11.   Percent of Class Represented by Amount in Row (9)

      0.4%

12.   Type of Reporting Person (See Instructions)

      PN

                               Page 6 of 13 Pages



CUSIP No. 090931106

1.    Names of Reporting Persons
      I.R.S. Identification Nos. of above persons (entities only)

      Apis Offshore Capital, Ltd.

2.    Check the Appropriate Box if a Member of a Group (See Instructions)

      (a) [ ]
      (b) [X]

3.    SEC Use Only

4.    Citizenship or Place of Organization

      Cayman Islands

NUMBER OF          5. SOLE VOTING POWER                                       0
SHARES
BENEFICIALLY       6. SHARED VOTING POWER                                89,570
OWNED BY EACH
REPORTING          7. SOLE DISPOSITIVE POWER                                  0
PERSON WITH:
                   8. SHARED DISPOSITIVE POWER                           89,570

9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      89,570

10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions) [ ]

11.   Percent of Class Represented by Amount in Row (9)

      1.5%

12.   Type of Reporting Person (See Instructions)

      CO

                               Page 7 of 13 Pages



CUSIP No. 090931106

1.    Names of Reporting Persons
      I.R.S. Identification Nos. of above persons (entities only)

      Apis Global Deep Value, LP

2.    Check the Appropriate Box if a Member of a Group (See Instructions)

      (a) [ ]
      (b) [X]

3.    SEC Use Only

4.    Citizenship or Place of Organization

      Delaware

NUMBER OF          5. SOLE VOTING POWER                                       0
SHARES
BENEFICIALLY       6. SHARED VOTING POWER                                36,388
OWNED BY EACH
REPORTING          7. SOLE DISPOSITIVE POWER                                  0
PERSON WITH:
                   8. SHARED DISPOSITIVE POWER                           36,388

9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      36,388

10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions) [ ]

11.   Percent of Class Represented by Amount in Row (9)

      0.6%

12.   Type of Reporting Person (See Instructions)

      PN

                               Page 8 of 13 Pages



CUSIP No. 090931106

1.    Names of Reporting Persons
      I.R.S. Identification Nos. of above persons (entities only)

      Apis Global Deep Value Offshore, Ltd.

2.    Check the Appropriate Box if a Member of a Group (See Instructions)

      (a) [ ]
      (b) [X]

3.    SEC Use Only

4.    Citizenship or Place of Organization

      Cayman Islands

NUMBER OF          5. SOLE VOTING POWER                                       0
SHARES
BENEFICIALLY       6. SHARED VOTING POWER                                60,654
OWNED BY EACH
REPORTING          7. SOLE DISPOSITIVE POWER                                  0
PERSON WITH:
                   8. SHARED DISPOSITIVE POWER                           60,654

9.    Aggregate Amount Beneficially Owned by Each Reporting Person

      60,654

10.   Check if the Aggregate Amount in Row (9) Excludes Certain Shares
      (See Instructions) [ ]

11.   Percent of Class Represented by Amount in Row (9)

      1.0%

12.   Type of Reporting Person (See Instructions)

      CO

                               Page 9 of 13 Pages



Item 1.

(a)   The name of the issuer is BioSpecifics Technologies Corp. (the "Issuer").

(b)   The principal executive offices of the Issuer are located at 35 Wilbur
      Street, Lynbrook, NY 11563.

Item 2.

(a)   This Statement on Schedule 13G (this "Statement") is being filed by (i)
      Apis Capital, LP, a Delaware limited partnership ("Apis Capital"), (ii)
      Apis Capital (QP), LP, a Delaware limited partnership ("Apis QP"), (iii)
      Apis Capital Offshore, Ltd., a Cayman Islands exempted company ("Apis
      Offshore"), (iv) Apis Global Deep Value, LP, a Delaware limited
      partnership ("Apis Deep Value"), (v) Apis Global Deep Value Offshore,
      Ltd., a Cayman Islands exempted company ("Apis Deep Value Offshore", and
      together with Apis Capital, Apis QP, Apis Offshore and Apis Deep Value,
      the "Funds"), (vi) Apis Capital Advisors, LLC, a Delaware limited
      liability company (the "Investment Manager"), which serves as the general
      partner and/or investment manager of the Funds, (vii) Steven A. Werber,
      Jr. and (viii) Daniel J. Barker (all of the foregoing, collectively, the
      "Filers"). Each Fund is a private investment vehicle formed for the
      purpose of investing and trading in a wide variety of securities and
      financial instruments. Messrs. Werber and Barker are the Managing Members
      of the Investment Manager and the Portfolio Managers for the Funds. The
      Funds directly own all of the respective shares reported in this Statement
      (other than the 3,800 shares directly owned by Daniel J. Barker). Messrs.
      Werber and Barker and the Investment Manager may be deemed to share with
      the Funds voting and dispositive power with respect to such shares. Each
      Filer disclaims beneficial ownership with respect to any shares other than
      those owned directly by such Filer.

(b)   The principal business office of Messrs. Werber and Barker, Apis Capital,
      Apis QP, Apis Deep Value and the Investment Manager is:

      53 Forest Avenue, Suite 103
      Old Greenwich, Connecticut 06870
      USA

      The principal business office of Apis Offshore and Apis Deep Value
      Offshore is:

      c/o dms Corporate Services Ltd.
      Ansbacher House
      20 Genesis Close, George Town
      PO Box 1344
      Grand Cayman KY1-1108
      Cayman Islands

                               Page 10 of 13 Pages



(c)   For citizenship information see Item 4 of the cover page of each Filer.

(d)   This Statement relates to the Common Stock, $0.001 par value, of the
      Issuer (the "Common Stock").

(e)   The CUSIP Number of the Common Stock is listed on the cover pages hereto.

Item 3. If this statement is filed pursuant to 240.13d-1(b) or 240.13d-2(b) or
(c), check whether the person filing is a:

(a)  [ ]   Broker or dealer registered under section 15 of the Act (15 U.S.C.
           78o).

(b)  [ ]   Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c)  [ ]   Insurance company as defined in section 3(a)(19) of the Act (15
           U.S.C. 78c).

(d)  [ ]   Investment company registered under section 8 of the Investment
           Company Act of 1940 (15 U.S.C. 80a-8).

(e)  [ ]   An investment adviser in accordance with 240.13d-1(b)(1)(ii)(E);

(f)  [ ]   An employee benefit plan or endowment fund in accordance with
           240.13d-1(b)(1)(ii)(F);

(g)  [ ]   A parent holding company or control person in accordance with
           240.13d-1(b)(1)(ii)(G);

(h)  [ ]   A savings associations as defined in Section 3(b) of the Federal
           Deposit Insurance Act (12 U.S.C. 1813);

(i)  [ ]   A church plan that is excluded from the definition of an investment
           company under section 3(c)(14) of the Investment Company Act of 1940
           (15 U.S.C. 80a-3);

(j)  [ ]   Group, in accordance with 240.13d-1(b)(1)(ii)(J).

Not applicable.

Item 4. Ownership.

See Items 5-9 and 11 on the cover page for each Filer, and Item 2, which
information is given as of December 31, 2008, and is based on 6,006,801 shares
of Common Stock outstanding as of November 4, 2008, as reported in the Issuer's
Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2008
filed on November 12, 2008.

Item 5. Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof
the reporting person has ceased to be the beneficial owner of more than five
percent of the class of securities, check the following: [X]

                               Page 11 of 13 Pages



Item 6. Ownership of More than Five Percent on Behalf of Another Person.

Not applicable.

Item 7. Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on By the Parent Holding Company.

Not applicable.

Item 8. Identification and Classification of Members of the Group.

Not applicable.

Item 9. Notice of Dissolution of Group.

Not applicable.

Item 10. Certification.

(a)   Not applicable.

(b)   By signing below I certify that, to the best of my knowledge and belief,
      the securities referred to above were not acquired and are not held for
      the purpose of or with the effect of changing or influencing the control
      of the issuer of the securities and were not acquired and are not held in
      connection with or as a participant in any transaction having that purpose
      or effect.

                               Page 12 of 13 Pages



                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Dated: February 17, 2009

                               DANIEL J. BARKER
                               APIS CAPITAL ADVISORS, LLC
                               APIS CAPITAL, LP
                               APIS CAPITAL (QP), LP
                               APIS CAPITAL OFFSHORE, LTD.
                               APIS GLOBAL DEEP VALUE, LP
                               APIS GLOBAL DEEP VALUE OFFSHORE, LTD.

                               By: /s/ Daniel J. Barker
                                   ---------------------------------------
                               Daniel J. Barker, for himself, as Managing
                               Member of the Investment Manager and as
                               Portfolio Manager of each of the Funds

                               /s/ Steven A. Werber, Jr.
                               -------------------------
                               Steven A. Werber, Jr.

                               Page 13 of 13 Pages