FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * YOWELL JOHN B   2. Issuer Name and Ticker or Trading Symbol OLD DOMINION FREIGHT LINE INC/VA [ODFL] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner __X__ Officer (give title below) __X__ Other (specify below) Executive VP and COO / Member of Section 13(d) group (Last) (First) (Middle) C/O OLD DOMINION FREIGHT LINE, INC., 500 OLD DOMINION WAY 3. Date of Earliest Transaction (Month/Day/Year) 09/15/2010 (Street) THOMASVILLE, NC 27360 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 09/15/2010   S(1)   966 D $ 25.3404 (2) 146,529 I As co-trustee of the Seth Morgan Yowell Irrevocable Declaration of Trust Common Stock 09/15/2010   S(1)   966 D $ 25.3404 (2) 146,529 I As co-trustee of the Megan Elise Yowell Irrevocable Declaration of Trust Common Stock 09/15/2010   S(1)   50 D $ 25.3404 (2) 46,663 I By Audrey L. Congdon Irrevocable Trust No. 2 dated 5/28/04 (David Congdon, Trustee) Common Stock 09/15/2010   S(1)   1,962 D $ 25.3404 (2) 829,827 I By wife as trustee for Audrey Lee Congdon Revocable Trust dated 2/17/05 Common Stock               58,198 I By wife as trustee for Irrevocable Trust Agreement dated 12/18/98 fbo Megan Yowell Common Stock               58,198 I By wife as trustee for Irrevocable Trust Agreement dated 12/18/98 fbo Seth Yowell Common Stock               104,856 D   Common Stock               257,188 I As trustee for Audrey L. Congdon Irrevocable Trust No. 1 dated 12/1/92 Common Stock               25,937 I By 401(k) plan Common Stock               8,929 I By wife Common Stock               430,651 I By wife as co-trustee of the Earl E. Congdon GRAT Remainder Trust Common Stock               150,000 I By wife as trustee for Audrey L. Congdon February 2010 Grantor Retained Annuitiy Trust Common Stock 09/16/2010   S(1)   3,927 D $ 25.962 (3) 142,602 I As co-trustee of the Seth Morgan Yowell Irrevocable Declaration of Trust Common Stock 09/16/2010   S(1)   1,183 D $ 26.1053 (4) 141,419 I As co-trustee of the Seth Morgan Yowell Irrevocable Declaration of Trust Common Stock 09/16/2010   S(1)   3,927 D $ 25.962 (3) 142,602 I As co-trustee of the Megan Elise Yowell Irrevocable Declaration of Trust Common Stock 09/16/2010   S(1)   1,183 D $ 26.1053 (4) 141,419 I As co-trustee of the Megan Elise Yowell Irrevocable Declaration of Trust Common Stock 09/16/2010   S(1)   205 D $ 25.962 (3) 46,458 I By Audrey L. Congdon Irrevocable Trust No. 2 dated 5/28/04 (David Congdon, Trustee) Common Stock 09/16/2010   S(1)   62 D $ 26.1053 (4) 46,396 I By Audrey L. Congdon Irrevocable Trust No. 2 dated 5/28/04 (David Congdon, Trustee) Common Stock 09/16/2010   S(1)   7,978 D $ 25.962 (3) 821,849 I By wife as trustee for Audrey Lee Congdon Revocable Trust dated 2/17/05 Common Stock 09/16/2010   S(1)   2,403 D $ 26.1053 (4) 819,446 I By wife as trustee for Audrey Lee Congdon Revocable Trust dated 2/17/05

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
YOWELL JOHN B C/O OLD DOMINION FREIGHT LINE, INC. 500 OLD DOMINION WAY THOMASVILLE, NC 27360		X	Executive VP and COO	Member of Section 13(d) group

Signatures

/s/ Joel B. McCarty, Jr., by Power of Attorney		09/17/2010
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 30, 2010.
(2)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.33 to $25.41, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
(3)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.33 to $26.20, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
(4)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.00 to $26.20, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
Remarks: The reporting person may be deemed to be a member of a "group" for purposes of Section 13(d) of the Exchange Act.  The other members of the Section 13(d) group are identified on a Schedule 13D filed with the Securities and Exchange Commission on September 9, 2010.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

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