Proxy Statement Pursuant to Section 14(a) of the
                         Securities Exchange Act of 1934

Filed by the Registrant |X|

Filed by a Party other than the Registrant |_|

Check the appropriate box:

|X|   Preliminary Proxy Statement                    |_|   Confidential, For Use
                                                           of the Commission
                                                           Only (as permitted by
                                                           Rule 14a-6(e)(2))

|_|   Definitive Proxy Statement

|_|   Definitive Additional Materials

|_|   Soliciting Material Pursuant to Rule 14a-12

                            Milestone Scientific Inc.
                (Name of Registrant as Specified in Its Charter)


          ------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if Other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

|X|   No fee required.



                            MILESTONE SCIENTIFIC INC.

      Notice of Annual Meeting of Stockholders to be held on June 27, 2003

                                   ----------

The Annual Meeting of Stockholders of Milestone Scientific Inc. (the "Company")
will be at the offices of Morse, Zelnick, Rose & Lander, LLP 405 Park Avenue
(14th Floor), New York, NY 10022 on Friday, June 27, 2003, at 9:00 a.m., Eastern
Daylight Time, for the purpose of considering and acting upon the following:

            1.    Election of five (5) Directors.

            2.    Amendment to the Certificate of Incorporation to increase the
                  authorized capitalization by adding a new class of 5,000,000
                  shares of preferred stock, par value $.0001 per share,
                  issuable in series, each with such rights, preferences and
                  privileges as are determined by the Board of Directors when
                  designating each series.

            3.    Any and all matters incident to the foregoing, and such other
                  business as may legally come before the meeting and any
                  adjournments or postponements thereof.

      The Board of Directors has fixed the close of business on May 30, 2003 as
the record date for determining the stockholders having the right to notice of
and to vote at the meeting.

                                              By order of the Board of Directors


                                              Leonard Osser
                                              Chairman of the Board

Livingston, New Jersey
May 30, 2003

--------------------------------------------------------------------------------
IMPORTANT:  Every stockholder, whether or not he or she expects to attend the
            annual meeting in person, is urged to execute the proxy and return
            it promptly in the enclosed business reply envelope.

            Sending in your Proxy will not prevent you from voting your stock at
            the meeting if you desire to do so, as your Proxy is revocable at
            your option.

            We would appreciate your giving this matter your prompt attention.



                            MILESTONE SCIENTIFIC INC.

                                   ----------

                                 PROXY STATEMENT
                       For Annual Meeting of Stockholders
                            to be Held June 27, 2003

                                   ----------

      Proxies in the form enclosed with this statement are solicited by
Milestone Scientific Inc. ("Milestone" or "the Company") to be used at the
Annual Meeting of stockholders to be held at the offices of Morse, Zelnick, Rose
& Lander, LLP 405 Park Avenue (14th Floor), New York, NY 10022 on Friday, June
27, 2003, at 9:00 a.m., Eastern Daylight Time, for the purposes set forth in the
Notice of Meeting and this Proxy Statement. Milestone's principal executive
offices are located at 220 South Orange Avenue, Livingston Corporate Park,
Livingston, New Jersey 07039. The approximate date on which this statement and
the accompanying proxy will be mailed to stockholders is June 3, 2003.

                          THE VOTING AND VOTE REQUIRED

      On the record date for the meeting, May 30, 2003, there were outstanding
12,633,370 shares of common stock of the Company (the "Common Stock"), each of
which will be entitled to one vote.

      Directors are elected by a plurality of the votes cast at the meeting. The
Amendment to the Certificate of Incorporation requires the affirmative vote of a
majority of the outstanding shares for adoption.

      All shares represented by valid proxies will be voted in accordance with
the instructions contained therein. In the absence of instructions, proxies will
be voted FOR each of the stated matters being voted on at the meeting. A proxy
may be revoked by the stockholder giving the proxy at any time before it is
voted, either by oral or written notice, and a prior proxy is automatically
revoked by a stockholder giving a subsequent proxy or attending and voting at
the meeting. Attendance at the meeting, however, in and of itself does not
revoke a prior proxy. In the case of the election of directors, shares
represented by a proxy marked "WITHHOLD AUTHORITY" to vote for all five nominees
will not be counted in determining whether a plurality vote has been received
for the election of directors. Shares represented by proxies marked "ABSTAIN" on
any other proposal will not be counted in determining whether the requisite vote
has been received for such proposal. In instances where brokers are prohibited
from exercising discretionary authority for beneficial owners who have not
returned proxies ("broker non-votes"), those shares will not be included in the
vote totals and, therefore, will have no effect on the outcome of the vote.

                 SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS

      The following table shows certain information with respect to beneficial
ownership of the Company's Common Stock on March 29, 2003 by all persons known
to be the beneficial owners of more than 5% of its outstanding shares, by each
director and by all Directors and Officers of the Company, as a group. No
Executive Officer or Director of the Company is involved in any material legal
proceedings.

                                                     Shares of
                                                    Common Stock
                                                    Beneficially      Percentage
 Name of Beneficial Owner(1)(2)                        Owned           of Class
--------------------------------                    ------------      ----------
Executive Officers and Directors
Leonard Osser                                       3,515,141(3)        26.46%

Stuart J. Wildhorn                                     21,334(4)            *

Thomas M. Stuckey                                      77,300(5)            *

Paul Gregory                                           12,572(6)            *

Jeffrey Fuller                                         20,000               *

Leslie Bernhard                                             0               *



                                                     Shares of
                                                    Common Stock
                                                    Beneficially      Percentage
 Name of Beneficial Owner(1)(2)                        Owned           of Class
--------------------------------                    ------------      ----------
Leonard M. Schiller                                    33,016(7)            *

All Directors & Officers as a group                 3,659,363           30.53%

5% and Greater Stockholders
K. Tucker Andersen
c/o Cumberland Associates, LLC
1114 Avenue of the Americas
New York, New York 10036                            1,612,599(9)         13.2%

Cumberland Associates, LLC
1114 Avenue of the Americas
New York, New York 10036                            1,171,672(10)        8.87%

Robert Gintel Florida Intangible Tax Trust
6 Greenwich Office Park
Greenwich, CT 06831                                 1,347,000(11)       12.18%

*Less than 1%

(1)   The addresses of the persons named in this table are as follows: Leonard
      A. Osser, 220 South Orange Avenue, Livingston Corporate Park, Livingston,
      NJ 07039; Thomas M. Stuckey, 220 South Orange Avenue, Livingston Corporate
      Park, Livingston, NJ 07039; Stuart Wildhorn, 220 South Orange Avenue,
      Livingston Corporate Park, Livingston, NJ 07039; Paul Gregory, Innovative
      Programs Associates Inc., 300 Mercer Street, New York, New York 10003; and
      Leonard M. Schiller, Schiller, Klein & McElroy, P.C., 33 North Dearborn
      Street, Suite 1030, Chicago, Illinois 60602.

(2)   A person is deemed to be a beneficial owner of securities that can be
      acquired by such person within 60 days from the filing of this proxy
      statement upon the exercise of options and warrants or conversion of
      convertible securities. Each beneficial owner's percentage ownership is
      determined by assuming that options, warrants and convertible securities
      that are held by such person (but not held by any other person) and that
      are exercisable or convertible within 60 days from the filing of this
      report have been exercise or converted. Except as otherwise indicated, and
      subject to applicable community property and similar laws, each of the
      persons named has sole voting and investment power with respect to the
      shares shown as beneficially owned. All percentages are determined based
      on the number of all shares, including those underlying options
      exercisable within 60 days from the filing of this proxy statement held by
      the named individual, divided by 12,633,370 outstanding shares on November
      4, 2002 and those shares underlying options exercisable within 60 days
      from the filing of this proxy statement, held by the named individual.

(3)   Includes (i) 614,183 shares issuable upon exercise of stock options within
      60 days of the date hereof, which are exercisable at $.80 and (ii)
      warrants immediately exercisable to purchase 35,714 shares at $1.75 per
      share.

(4)   Includes 16,667 shares subject to stock options, exercisable within 60
      days of the date hereof at $2.50 per share and 4,667 shares subject to
      stock options, exercisable within 60 days of the date hereof at $.75 per
      share.

(5)   Includes 21,000 shares subject to stock options, exercisable within 60
      days of the date hereof at $3.00 per share, 25,000 shares subject to stock
      options, exercisable within 60 days of the date hereof at $16.50 per
      share, and 16,667 shares subject to stock options, exercisable within 60
      days of the date hereof at $2.1875 per share, 4,667 shares subject to
      stock options exercisable within 60 days of the date hereof at $2.50 per
      share and 2,333 shares subject to stock options exercisable within 60 days
      of the date hereof at $.75 per share. Mr. Stuckey disclaims beneficial
      ownership of (i) 10,000 shares, which are held by his wife as custodian
      for their children, and (ii) 1,700 shares which are owned by his wife in
      her IRA.

(6)   Includes 150 shares held by Mr. Gregory's wife and 12,422 shares subject
      to stock options, exercisable within 60 days of the date hereof at $2.1875
      per share.

(7)   Includes 12,422 shares subject to stock options, exercisable within 60
      days of the date hereof at $2.1875 per share.

(8)   Includes 728,694 shares subject to stock options and 35,714 shares subject
      to warrants all of which are exercisable within sixty (60) days of the
      date hereof.

(9)   Based solely upon an amendment to Schedule 13G filed by K. Tucker Andersen
      with the Securities and Exchange Commission on 1/17/02.


                                       2


(10)  Based solely upon an amendment to Schedule 13G filed by Cumberland
      Associates, LLC with the Securities and Exchange Commission on 2/14/03.

(11)  The 1,347,000 shares attributable to the Trust are owned by the Trust or
      other entities, which the Trust owns or is otherwise affiliated with,
      including Gintel & Co., Gintel Asset Management, Inc., and the Gintel
      Fund. The Trust is the 100% shareholder of Gintel Asset Management, Inc.
      (the investment advisor to Gintel Fund) and Gintel & Co., LLC, and Robert
      M. Gintel is the beneficiary of the Trust. Excludes 150,000 shares held by
      Gintel Partners Fund LP of which Robert Gintel, Chief Executive Officer of
      Gintel Asset Management, Inc. is a controlling partner, 110,000 shares
      held by Barbara Gintel (Robert Gintel's spouse),

                      Equity Compensation Plan Information
--------------------------------------------------------------------------------

      The following table summarizes the (i) options granted under the Milestone
1997 Stock Option Plan, and (ii) options and warrants granted outside the
Milestone 1997 Stock Option Plan, as of December 31, 2002. The shares covered by
outstanding options and warrants are subject to adjustment for changes in
capitalization stock splits, stock dividends and similar events. No other equity
compensation has been issued.



                                                                     Equity Compensation Plan Table
                                                   -----------------------------------------------------------------
                                                         Number of                                   Number of
                                                    securities(1) to be     Weighted-average        securities(1)
                                                    issued upon exercise    exercise price of    remaining available
                                                       of outstanding          outstanding       for future issuance
                                                   options, warrants and    options, warrants        under equity
                                                           rights               and rights        compensation plans
                                                   -----------------------------------------------------------------
                                                                                           
Equity Compensation Plans Approved By
Security Holders

Grants under the Milestone Scientific, Inc.
1997 Stock Option Plan .........................           741,844                $4.08                    258,156

Equity Compensation Plans Not Requiring
Approval By Security Holders

Aggregate Individual Option Grants .............           513,500                $3.91             Not applicable

Aggregate Individual Warrant Grants ............         1,004,816                $1.45             Not applicable
                                                         ---------                -----             --------------
             Total .............................         2,260,160                $2.87
                                                         ---------                -----             --------------


      (1)   Reflect shares of Milestone Common Stock.

The aggregate individual option grants outside the Stock Option Plan referred to
in the table above include options granted to consultants and providers of
certain services to the company. The aggregate individual warrant grants
referred to in the table above include warrants granted to investors in the
company as part of private placements and credit line arrangement.

                              ELECTION OF DIRECTORS

      Five directors are to be elected at the Annual Meeting, each for a term of
one year and until the election and qualification of a successor.

      It is intended that votes pursuant to the enclosed proxy will be cast for
the election of the five nominees named below. In the event that any such
nominee should become unable or unwilling to serve as a Director, the Proxy will
be voted for the election of such person, if any, as shall be designated by the
Board of Directors (the "Board"). Management has no reason to believe these
nominees will not be available for election.

      The nominees for election and certain information about them are shown in
the following table:


                                       3


Nominees for Election

LEONARD OSSER, 55, has been Chief Executive Officer and a director of the
Company since July 1991, and the President and Chief Executive Officer of
Spintech, a subsidiary of the Company, since November, 1995. From July 1991
until July 1997, he also served as President and Chief Financial Officer of the
Company.

PAUL GREGORY, 65, has been a director of the Company since April 1997. Mr.
Gregory has been a business and insurance consultant at Innovative Programs
Associates Inc. and Paul Gregory Associates Inc. since January 1995 and January
1986, respectively, where he services, among other entities, foreign and
domestic insurance groups, law and accounting firms and international
corporations.

LEONARD M. SCHILLER, 62, has been a director of the Company since April 1997.
Mr. Schiller has been a partner in the law firm of Schiller, Klein & McElroy,
P.C. in Chicago, Illinois since 1977. He has also served as the President of The
Dearborn Group, a residential property management and real estate acquisition
company.

JEFFREY FULLER, 57 has been a director Milestone since January 16, 2003. Mr.
Fuller is president and owner of a municipal water supply systems, Hudson Valley
Water Company and Lake Lenepe Water Company, and in addition has been an
executive recruiter since 1995.

LESLIE BERNHARD, 59, is the co-founder, president, chief executive officer and
director of AdStar, Inc., a reporting company, the leading application service
provider for the newspaper classified advertising industry.

      The Board unanimously recommends a vote FOR the election of each of the
nominees.

Board of Directors and Committees

      The Board held five meetings, the Audit Committee two meetings and the
Compensation Committee one meeting during fiscal year 2002. The Company does not
have a nominating committee. All directors attended more than 75% of the
aggregate number of meetings of the Board and its committees. Stephen A. Zelnick
resigned from the Board of Directors on August 19, 2002, Jeffrey Fuller was
appointed to the Board on January 16, 2003 and Leslie Bernhard was appointed to
the Board on May 19, 2003.

      The Compensation Committee reviews and recommends to the Board the
compensation and benefits of all officers of the Company, reviews general policy
matters relating to compensation and benefits of employees of the Company, and
administers the issuance of stock options to the Company's officers, employees,
directors and consultants. The Compensation Committee is comprised of Leonard M.
Schiller, Paul Gregory and Jeffrey Fuller.

      The Audit Committee was established to meet with management and the
Company's independent accountants to determine the adequacy of internal controls
and other financial reporting matters. The Board has adopted a written charter
for the Audit Committee. The Audit Committee reviewed the Company's audited
financial statements for the year ended December 31, 2002 and met with the
management of the Company to discuss such audited financial statements. The
Audit Committee has discussed with the Company's independent accountants, J. H.
Cohn LLP, the matters required to be discussed pursuant to Statement on
Accounting Standards No. 61. The Audit Committee has received the written
disclosures and the letter from J. H. Cohn LLP required by the Independence
Standards Board Standard No. 1. The Audit Committee has discussed with J. H.
Cohn LLP its independence from management and the Company. J. H. Cohn LLP had
full and free access to the Audit Committee. Based on its review and
discussions, the Audit Committee recommended to the Board of Directors that the


                                       4


audited financial statements be included in the Company's Annual Report on Form
10-KSB. The Audit Committee is comprised of Leonard M. Schiller, Paul Gregory
and Jeffrey Fuller, all of whom are independent (as defined in Section 121(A) of
the American Stock Exchange Listing Standards).

                     COMPENSATION OF DIRECTORS AND OFFICERS
                               AND RELATED MATTERS

Executive Compensation.

      The following Summary Compensation Table sets forth all compensation
earned, in all capacities, during the fiscal years ended December 31, 2002,
2001, and 2000 by (i) the Company's Chief Executive Officer and (ii) the most
highly compensated executive officers, other than the CEO, who were serving as
executive officers at the end of the 2002 fiscal year and whose salary as
determined by Regulation S-B, Item 402, exceeded $100,000 (the individuals
falling within categories (i) and (ii) are collectively referred to as the
"Named Executives").

                           Summary Compensation Table


                                                                    Awards
                                         Annual Compensation     Common Stock
                                               Salary         Underlying Options
 Name and Principal Position      Year           ($)                  (#)

Leonard A. Osser
     Chief Executive              2002        351,800(1)            50,000
     Officer and                  2001        350,967(2)            50,000
     Chairman                     2000        265,407(3)            50,000
Stuart J. Wildhorn Senior Vice    2002           155,400             7,000
President                         2001            93,750            50,000
Thomas M. Stuckey
     Chief Financial              2002        136,267(4)             7,000
     Officer and Vice             2001           116,905            10,000
     President                    2000           114,051            25,000

----------
(1)   Includes $320,000 in deferred compensation, of which $284,000 earned as
      Chairman and CEO of Milestone and $36,000 earned as President and CEO of
      Spintech. It excludes $19,049 paid by Milestone to Marilyn Elson, a
      certified public account, who was employed by Milestone to render
      professional tax services. Ms. Elson is the wife of Mr. Osser.

(2)   Includes $350,000 in deferred compensation, of which $314,000 earned as
      Chairman and CEO of Milestone and $36,000 earned as President and CEO of
      Spintech. The deferred compensation was paid subsequent to year end
      through the issuance of 625,000 units, each consisting of one share of
      common stock and one six-year warrant to purchase one share of common
      stock at prices ranging from $.80-$2.00. It excludes $20,850 paid by
      Milestone to Marilyn Elson, a certified public account, who was employed
      by Milestone to render professional tax services. Ms. Elson is the wife of
      Mr. Osser.

(3)   Includes $141,346 in deferred compensation and $21,000 earned as President
      and Chief Executive Officer of Spintech. The deferred compensation was
      paid subsequent to year end through the issuance of 176,683 units, each
      consisting of one share of common stock and one six-year warrant to
      purchase one share of common stock at prices ranging from $.80-$2.00.

Stock Options

      The following tables show certain information with respect to incentive
and non-qualified stock options granted in 2002 to Named Executives under the
Company's 1997 Stock Option Plan and the aggregate value at May 1, 2003 of such
options. In general, the per share exercise price of all options is


                                       5


equal to the fair market value of a share of Common Stock on the date of grant.
No options granted to Named Executives have been exercised.

                              Option Grants in 2002
                          Individual Grants of Options

                      Number of         Percent of
                      Shares of       Total Options
                     Common Stock       Granted to       Exercise
                      Underlying       Employees in       Price       Expiration
       Name            Option #            2002           ($/Sh)         Date
------------------   ------------     -------------      --------     ----------
Leonard A. Osser       50,000(1)           28.9%           $.55        01-01-07
Stuart J. Wildhorn      7,000(2)              4%           $.75        07-27-07
Thomas M. Stuckey       7,000(2)              4%           $.75        07-27-07

----------
(1)   Options vested 01-01-03

(2)   One third vested when issued and one third vesting on each of the next two
      anniversaries.

                     Aggregated 2002 Year End Options Values
                  for Options granted prior to and during 2002

                       Number of Shares of Common
                      Stock Underlying Unexercised       Value of Unexercised
                               Options at                In-The-Money Options
                               12-31-2002                  At 12-31-2002 (1)
      Name             Exercisable/Unexercisable       Exercisable/Unexercisable
------------------     -------------------------       -------------------------
Leonard A. Osser               0 // 200,000                    $0 // $0
Stuart J. Wildhorn         19,000 // 38,000                    $0 // $0
Thomas M. Stuckey          71,667 // 16,333                    $0 // $0

----------
(1)   Based on the closing price on May 15, 2003 of $.35 as quoted on the
      American Stock Exchange.

Employment Contracts

      As of January 1, 1998 the Company entered into an Employment Agreement
with Mr. Osser which provides for an initial term expiring on December 31, 2002,
with a two-year non-competition period at the end of the term. The term is
automatically increased for successive one-year periods unless prior to December
1 of any year either party notifies the other of its election not to extend the
term. Under the Agreement, Mr. Osser serves as Chief Executive Officer and is
required to work on a full-time basis. Under the Employment Agreement, Mr. Osser
receives annual base pay of $350,000, increasing to reflect cost of living
adjustments commencing on January 1, 2001. In addition, during each January from
1998 through 2002 the Company has granted to Mr. Osser, pursuant to the
Employment Agreement, an option to purchase 50,000 shares of Common Stock
exercisable only during the last 30 days of the five-year option term unless the
Company achieves certain financial goals to be specified annually by the
Compensation Committee. Additionally, as soon as financial statements for each
year commencing with 1998 are completed, the Company shall grant the executive
an additional option to purchase up to 50,000 shares depending upon the
achievement of specified performance goals. Further, Mr. Osser shall receive the
opportunity to earn cash bonuses of up to $200,000 per year depending upon the
achievement of performance targets to be specified by the Option Committee.

      On July 7, 1998, at his sole discretion, Mr. Osser implemented a voluntary
reduction of his annual base salary, reducing his annual base pay from $350,000
to $188,462. The voluntary reduction has been described by Mr. Osser as being
both temporary and having no effect upon his rights under his Employment
Agreement with the Company. Such reduction remained in effect until August 5,
2000. At that time, Mr.


                                       6


Osser began to defer his salary at the $350,000 annual base. At December 31,
2000, his deferred compensation was $141,346. In December 2001, Milestone
reached an agreement with Mr. Osser to satisfy the $491,346 of unpaid salary.
The agreement calls for the issuance of 614,183 units. Each unit consists of one
share of Milestone common stock and one warrant to purchase an additional share
of such common stock. The warrants will be exercisable at $.80 per share through
January 31, 2003, thereafter at $1.00 per share through January 31, 2006, and
thereafter at $2.00 per share through January 31, 2007, at which time they will
expire. On March 31, 2003, Mr. Osser signed an agreement deferring $640,000 of
his annual salary until April 1, 2003.

Compensation of Directors

      In 2003, each non-employee directors was granted a five-year option to
purchase 20,000 shares of our Common Stock at an exercise price of $1.50 per
share, a price above the fair market value of a share of Common Stock on the
date of grant. The option vests over two years. A similar option was granted to
Leslie Bernhard upon her appointment to the Board in 2003. Directors receive no
cash compensation.

                    AMENDMENT TO CERTIFICATE OF INCORPORATION

      On May 14, 2003 the Board of Directors adopted, subject to Stockholder
approval, an amendment to Milestone's Certificate of Incorporation increasing
the authorized capitalization by 5,000,000 shares of Preferred Stock, par value
$.0001 per share, issuable in series, each series possessing such rights,
preferences and privileges as are determined by the Board of Directors upon the
designation of that series. If the outstanding shares of any series are given
voting rights, they will vote together with the Common Stock as one class and
such voting rights will not be superior to the voting rights of the Common
Stock. Nonconvertible shares of any series will not be granted more than one
vote per share and each share of a convertible series will not be granted the
right to more than one vote for each share of Common Stock into which it is
convertible. Stockholder authorization of this class of Preferred Stock would
leave within the discretion of the Board the determination of matters such as
dividend rights or interest rates, conversion privileges, redemption prices,
liquidation preferences and other rights and enable the Board to fix these
rights without additional Stockholder approval. Authorization for preferred
stock of the type now being sought by Milestone, sometimes referred to as
"Variable Preferred Stock" or "Blank Check Preferred Stock" is possessed by many
corporations and would provide Milestone with a flexible financial instrument
which could be used by it in merger or acquisition transactions, in satisfaction
of existing indebtedness, in payment of trade creditors or in future financing
transactions. Accordingly, the Board believes, that having authorized "Blank
Check" Preferred Stock will provide Milestone with increased flexibility in
structuring and a greater possibility of effecting one or more of the foregoing
transactions. However, at the present time there are no agreements or any
specific plans with respect to the use of this Preferred Stock.

                 The Board recommends a vote FOR this proposal.

Certain Relationships and Related Transactions

      In December 2001, the Company reached an agreement with Mr. Osser to
satisfy $491,346 of his deferred compensation through the issuance of 614,183
units, each unit consisted of one share of Milestone common stock and one
warrant to purchase an additional share of each stock. These units were issued
to Mr. Osser in January 2002.

Section 16(a) Beneficial Ownership Reporting Compliance

      Section 16(a) of the Securities Exchange Act of 1934 requires the
Company's officers and directors, and persons who own more than ten percent
(10%) of a registered class of the Company's


                                       7


equity securities to file reports of ownership and changes in ownership with the
Securities and Exchange Commission ("SEC"). Officers, directors and greater than
ten percent (10%) stockholders are required by SEC regulations to furnish the
Company with copies of all Section 16(a) forms they file.

      To the best of the Company's knowledge, based solely on review of the
copies of such forms furnished to the Company, or written representations that
no other forms were required, the Company believes that all Section 16(a) filing
requirements applicable to its officers, directors and greater than ten percent
(10%) shareholders were complied with during 2002.

                                  MISCELLANEOUS

Other Matters

      Management knows of no matter other than the foregoing to be brought
before the Annual Meeting of Stockholders, but if such other matters properly
come before the meeting, or any adjournment thereof, the persons named in the
accompanying form of proxy will vote such proxy on such matters in accordance
with their best judgment.

Reports and Financial Statements

      The Company's Annual Report to Stockholders for the year ended December
31, 2002, including Audited Financial Statements, is included with this proxy
material. The Financial Statements contained therein are incorporated by
reference and are deemed part of this soliciting material.

Solicitation of Proxies

      The entire cost of the solicitation of proxies will be borne by Milestone.
Proxies may be solicited by directors, officers and regular employees of
Milestone, without extra compensation, by telephone, telegraph, mail or personal
interview. Solicitation is not to be made by specifically engaged employees or
paid solicitors. Milestone will also reimburse brokerage houses and other
custodians, nominees and fiduciaries for their reasonable expenses for sending
proxies and proxy material to the beneficial owners of its Common Stock.

Stockholder Proposals

      Stockholder proposals intended to be presented at the Company's 2004
Annual Meeting must be received by the Company for inclusion in the Company's
proxy statement relating to that meeting not later than March 1, 2004. Such
proposals should be addressed to Thomas M. Stuckey, Chief Financial officer,
Milestone Scientific Inc., 220 South Orange Avenue, Livingston Corporate Park,
Livingston, New Jersey 07039.

      EVERY STOCKHOLDER, WHETHER OR NOT HE OR SHE EXPECTS TO ATTEND THE ANNUAL
MEETING IN PERSON, IS URGED TO EXECUTE THE PROXY AND RETURN IT PROMPTLY IN THE
ENCLOSED BUSINESS REPLY ENVELOPE.

                                              By order of the Board of Directors


                                              Leonard Osser
                                              Chairman of the Board

Livingston, New Jersey
May 30, 2003


                                       8


                            MILESTONE SCIENTIFIC INC.

    This proxy is solicited by the Board of Directors for the Annual Meeting
                            on Friday, June 27, 2003

      The undersigned hereby appoints Leonard Osser and Thomas M. Stuckey, and
each of them, with full power of substitution, the attorneys and proxies of the
undersigned to attend the Annual Meeting of Stockholders of Milestone Scientific
Inc. (the "Company") to be held on Friday, June 27, 2003 at the offices of
Morse, Zelnick, Rose & Lander, LLP 405 Park Avenue (14th Floor), New York, NY
10022 on Friday, June 27, 2003, at 9:00 a.m., Eastern Daylight Time, a.m., and
at any adjournment thereof, hereby revoking any proxies heretofore given, to
vote all shares of common stock of the Company held or owned by the undersigned
as indicated on the proposals as more fully set forth in the Proxy Statement,
and in their discretion upon such other matters as may come before the meeting.

1.    ELECTION OF DIRECTORS---Leonard Osser, Leslie Bernhard, Jeffrey Fuller,
      Paul Gregory and Leonard M. Schiller.

      For all nominees                                                  |_|
      Withhold authority to vote for all nominees                       |_|
      For all nominees, Except nominee(s) written below.

2.    Approval of Amendment to the Certificate of Incorporation adding a new
      class of Preferred Stock

                FOR |_|              AGAINST |_|             ABSTAIN |_|

                                  (Continued, and to be signed, on Reverse Side)



      The shares represented by this Proxy will be voted as directed or if no
direction is indicated, will be voted FOR all nominees for director and FOR the
proposal.

      The undersigned hereby acknowledges receipt of the Notice of, and Proxy
Statement for, the aforesaid Annual Meeting.

                                           Dated:_________________________, 2003


                                           -------------------------------------
                                                  Signature of Stockholder


                                           -------------------------------------
                                                  Signature of Stockholder

                                           DATE AND SIGN EXACTLY AS NAME APPEARS
                                           HEREON EACH JOINT TENANT MUST SIGN
                                           WHEN SIGNING AS ATTORNEY, EXECUTOR,
                                           TRUSTEEE, ETC., GIVE FULL TITLE. IF
                                           SIGNER IS CORPORATION SIGN IN FULL
                                           CORPORATE NAME BY AUTHORIZED OFFICER