Rule 424(b)(3) and (c)
                                                   Commission File No. 333-54732

PROSPECTUS SUPPLEMENT

                            MILESTONE SCIENTIFIC INC.

                                2,275,000 shares
                                       of
                                  Common Stock

                                ----------------

      The following information supplements and amends the Prospectus of
Milestone Scientific Inc. ("Milestone") dated May 5, 2001, as amended in a
Post-Effective Amendment filed with the Securities and Exchange Commission on
September 16, 2003, relating to the issuance of 2,275,000 shares of Milestone's
common stock. This Supplement should be read in conjunction with that Prospectus
and Post-Effective Amendment.

      On October 3, 2003, Milestone issued its first drawdown notice to
Hillgreen Investment Limited ("Hillgreen"), under the Private Equity Line of
Credit Agreement delivered and effective on January 19, 2001, evidencing an
equity line agreement between Milestone and Hillgreen. This notice offered to
sell up to U.S. $100,000 in aggregate traded value of Milestone common shares to
Hillgreen under the pricing formula set forth in the equity line agreement,
during the ten trading day pricing period commencing on October 7, 2003 and
ending on October 20, 2003 at no less than a traded value of U.S. $1.05 per
share. Pursuant to the calculation done at the end of the pricing period,
Milestone issued 57,539 shares of common stock to Hillgreen in consideration for
$100,000 in this first drawdown.

--------------------------------------------------------------------------------

           The date of this Prospectus Supplement is October 21, 2003



                                   PROSPECTUS

                                     [LOGO]

                                2,275,000 Shares
                                 of Common Stock

      This prospectus may be used only in connection with resales of our common
stock by Hillgreen Investments Limited ("Hillgreen") and Jesup & Lamont
Securities Corporation ("Jesup & Lamont") (collectively, the "selling
stockholders"). Hillgreen will purchase up to 2,100,000 shares of our common
stock upon our exercise of a series of put options under the equity line of
credit agreement described in this prospectus and up to 100,000 shares upon the
exercise by Hillgreen of warrants granted under that agreement. Jesup & Lamont
will purchase up to 75,000 shares of our common stock upon its exercise of
warrants granted to it as a placement fee in connection with the equity line.
The shares of common stock, which may be sold to Hillgreen at our option, will
constitute 16.6% of our issued and outstanding shares as of August 17, 2003.

      We will not receive any proceeds from the sale of shares by the selling
stockholders. However, we will receive the sale price of any common stock that
we sell to Hillgreen under the equity line of credit agreement and the exercise
price payable upon the exercise for cash of the warrants held by Hillgreen and
Jesup & Lamont.

      The selling stockholders may sell shares of our common stock from time to
time on the American Stock Exchange at the prevailing market price or in
private, negotiated transactions. The shares will be sold at prices determined
by the selling stockholders. The selling stockholders may sell the shares
through broker-dealers who may receive compensation from the selling
stockholders in the form of discounts or commissions. Hillgreen is an
"underwriter" within the meaning of the Securities Act of 1933 in connection
with its sales of our shares. We will pay the costs of registering the shares
under this prospectus, including legal fees.

      Our common stock is quoted on the American Stock Exchange under the symbol
"MS." The last reported sale price of our common stock on the American Stock
Exchange on September 12, 2003 was $1.41 per share.

      Investing in our common stock involves a high degree of risk. See "Risk
Factors" beginning on page 5.

      Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved of these securities or determined if this
prospectus is truthful or complete. Any representation to the contrary is a
criminal offense.

                        Prospectus dated October 3, 2003



                                TABLE OF CONTENTS

PROSPECTUS SUMMARY........................................................... 3
THE OFFERING................................................................. 4
RISK FACTORS................................................................. 5
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS............................ 10
USE OF PROCEEDS.............................................................. 10
PRICE RANGE OF COMMON STOCK.................................................. 11
DIVIDEND POLICY.............................................................. 11
CAPITALIZATION............................................................... 12
EQUITY LINE OF CREDIT AGREEMENT.............................................. 13
SELLING STOCKHOLDERS......................................................... 19
PLAN OF DISTRIBUTION......................................................... 19
DESCRIPTION OF CAPITAL STOCK................................................. 24
WHERE YOU CAN FIND MORE INFORMATION.......................................... 25
INCORPORATION OF INFORMATION BY REFERENCE.................................... 26
MATERIAL CHANGES............................................................. 26
LEGAL MATTERS................................................................ 27
EXPERTS...................................................................... 27

                          -----------------------------

      You should rely only on the information contained in this prospectus or
incorporated by reference in this prospectus. We have not authorized anyone to
provide you with different information. We are not making an offer of these
securities in any state where the offer is not permitted. You should not assume
that the information provided by this prospectus is accurate as of any date
other than the date on the front of this prospectus.

      All references in this prospectus and in documents incorporated by
reference in this prospectus, to "we," "us," "our," "Milestone" or "the Company"
refer to Milestone Scientific Inc. and its 88.65% owned subsidiary, Spintech,
Inc. ("Spintech"), unless the context otherwise indicates.

      We maintain a web site at www.milesci.com. Information contained on our
website is not part of this prospectus.

      The Wand, The WandPlus, the SafetyWand, CompuDent, CompuMed, and Compuflo
are trademarks of Milestone.



                               PROSPECTUS SUMMARY

      This summary highlights information contained or incorporated by reference
in this prospectus. For a more complete understanding of this offering, you
should read the entire prospectus carefully, especially the "Risk Factors"
section, and our financial statements and notes to those statements incorporated
by reference in this prospectus, before making your investment decision.

                            Milestone Scientific Inc.

      We have developed and, since January 1998, have manufactured, marketed and
sold CompuDent,a "painless" injection system enabling the dental practitioner to
more quickly and effectively anesthetize patients. CompuDent consists of a
computer controlled pump and a disposable handpiece. Through December 31, 2000,
we marketed CompuDent only for use in dentistry. In 2000, we received approval
from the Food and Drug Administration to also market CompuMed, a similar system,
for use in medicine and we are currently exploring medical applications for
CompuDent, both for the administration of anesthesia and for the infusion and
removal of other fluids. CompuDent was originally sold in the U.S. and Canada
through major distributors of dental products. In September 1999 we began
selling CompuDent and its disposable handpieces directly to dentists in the
United States.

      We were organized in August 1989 under the laws of Delaware. Our principal
executive office is located at 220 South Orange Avenue, Livingston Corporate
Park, Livingston, New Jersey 07039. Our telephone number is (973) 716-0087.


                                       3


                                  THE OFFERING

Common Stock
Offered by the Selling
Stockholders                  2,275,000 shares

Offering Price                To be determined at the time of sale by the
                              selling stockholders

Common Stock Outstanding

Before the Offering.          12,633,370 shares (1)

After the Offering            14,908,370 shares (2) (3)

Use of Proceeds               We will not receive any proceeds from sales by the
                              selling stockholders. However, we will receive the
                              proceeds from any sale of common stock to
                              Hillgreen under the equity line of credit
                              agreement and upon the exercise of warrants held
                              by Hillgreen and Jesup & Lamont when, and if, they
                              pay the exercise price in cash. We expect to use
                              substantially all the net proceeds for general
                              corporate purposes, such as working capital,
                              expansion of sales and marketing activities, debt
                              repayment, the launching of our medical operation
                              including clinical trials and the
                              commercialization of our SafetyWand product.

Risk Factors                  Investing in our common stock involves a high
                              degree of risk and immediate dilution. You should
                              not purchase our common stock unless you can
                              afford the complete loss of your investment.
                              Before purchasing our common stock, you should
                              review carefully and consider all information
                              contained in this prospectus, particularly the
                              items under the section entitled "Risk Factors."

American Stock
Exchange symbol               MS

----------

(1)   As of August 31, 2003.

(2)   This figure excludes:

      o     663,344 shares subject to outstanding stock options previously
            granted under our stock option plan as of August 31, 2003;

      o     336,656 shares available for future grant under our stock option
            plan; and

      o     2,622,470 shares subject to other outstanding stock options and
            warrants.

(3)   Assumes 2,100,000 shares of common stock are issued under the equity line
      of credit agreement and all 175,000 warrants granted to Hillgreen and
      Jesup & Lamont are exercised.


                                       4


                                  RISK FACTORS

A purchase of our common stock is speculative and involves a high degree of
risk. You should carefully consider the risks described below together with all
of the other information included or incorporated by reference in this
prospectus before making an investment decision. The risks and uncertainties
described below are not the only ones facing our company. If any of the
following risks actually occur, our business, financial condition or operating
results could be harmed. In that case, the trading price of our common stock
could decline, and you could lose all or part of your investment.

      The following factors may affect the growth and profitability of Milestone
and should be considered by any prospective purchaser of Milestone's securities:

      Continuing losses may exhaust our capital resources and force us to
terminate operations. We are currently losing money and, based on our history,
there is significant risk that losses will continue. Since our operations
commenced in November 1995, we have had losses for each year, including a loss
of approximately $2.5 million for 2002. At June 30, 2003, we had an accumulated
deficit of approximately $43 million. If we continue to incur losses we may
exhaust our capital resources. In that case, unless we raise additional capital
we may be forced to terminate or curtail operations.

      We cannot become successful unless we gain greater market acceptance for
CompuDent and its disposable handpiece. We cannot become successful unless
dentists in larger numbers buy CompuDent and its disposable handpiece and use it
to administer oral anesthesia. This depends, in large part, upon our ability to
educate dentists and other health care providers of the distinctive
characteristics and benefits of CompuDent and will require substantial marketing
efforts and expense. Even though more than 3,800 equipment units have been sold
in the domestic market over the last three years, less than 5 million disposable
handpieces were sold during that period, reflecting a low level of usage of
CompuDent. We cannot assure you that CompuDent will be accepted by the market.

      We need additional capital to expand marketing efforts. Our capital
requirements continue to be significant and, unless we borrow funds or sell
equity securities, we will be forced to curtail or further reduce our
activities. We have no agreement for future additional financing. We cannot
assure you that any sources of additional financing will be available on
acceptable terms, or at all. To the extent that any future financing involves
the sale of our equity securities, the ownership interest of our stockholders
could be substantially diluted.

      We depend on Hillgreen to provide us with capital under the equity line of
credit agreement. Our immediate financing needs depend on our ability to sell
shares of our common stock to Hillgreen under the equity line of credit
agreement. Factors that could adversely affect our ability to sell shares of our
common stock to Hillgreen under the equity line of credit agreement include:

      o     Hillgreen's ability or willingness to perform its obligations under
            the agreement; and

      o     The trading price and volume of our stock. If the market price is
            low or the volume is thin, we may not be able to sell a sufficient
            number of shares to meet our capital requirements.


                                       5


      We may require additional financing in the future, which may not be
available on acceptable terms. Depending on the amount of money we raise under
the equity line of credit agreement with Hillgreen and our ability to generate
additional revenues, we may require additional funds for working capital, debt
repayment, expanding our operations, or for general corporate purposes. At this
time, we can offer no assurances that sales of CompuDent will reach the level
required to sustain our operations and growth plans in the near term. Therefore,
we are actively pursuing additional financing alternatives. However, other than
the equity line of credit with Hillgreen, we do not have any commitments for
additional financing and we cannot assure you that any additional financing will
be available or, if available, will be offered on acceptable terms. The equity
line of credit agreement limits our ability to sell our securities to third
parties at a discount to the market price during its term. Accordingly, if we
need additional capital but are unable to draw down under the equity line of
credit agreement for any reason, our access to capital may be limited. In
addition, any additional equity financing may be dilutive to stockholders, and
debt financings, if available, may involve restrictive covenants that further
limit our ability to make decisions that we believe will be in our best
interests. In the event we cannot obtain additional financing on terms
acceptable to us when required, our operations will be materially and adversely
affected and we will have to cease or substantially reduce operations.

      Our limited domestic distribution channel must be expanded for us to
become successful. Revenue growth depends on our ability to expand marketing
efforts for CompuDent. Until September 1999 we relied, primarily, on independent
dental distributors to sell The Wand(R) domestically and internationally. Since
then we have sought to build a domestic sales force as well, but its efforts in
marketing CompuDent remain quite limited. To increase marketing of CompuDent
with our own sales force, the sales force will require substantial expansion and
we will incur significant up-front expense. We cannot assure you that we will be
able to hire and retain our own adequate sales force or that our sales force
will be able to successfully market and sell CompuDent.

      We may be unable to protect our patents and intellectual property because
of our limited capital resources. We hold U.S. patents applicable to CompuDent,
CompuMed, The Wand and SafetyWand. We rely on a combination of patents,
trademarks and nondisclosure agreements to protect our intellectual property
rights. Unauthorized parties may attempt to reverse engineer, copy, or obtain
and use our products and other information we regard as proprietary. We may have
to initiate lawsuits to protect our intellectual property rights. These lawsuits
are costly and divert management's time and effort away from our business with
no guarantee of success. Our failure to protect our proprietary rights or the
expense of doing so could have a materially adverse effect on our operating
results and financial condition. Also, although we are not involved in any
litigation involving our intellectual property and we have not received any
claims of infringement, it is possible that our products may infringe on patent
or proprietary rights of others. If that happens we may have to modify our
products or obtain a license. We cannot assure you that we will be able to do so
in a timely manner, upon acceptable terms and conditions, or at all.

      Our terminable relationships with key manufacturers could disrupt critical
supplies. We have informal terminable arrangements with the manufacturers of the
CompuDent and CompuMed equipment units, Tricor Systems, Inc., and handpieces,
NYPRO, Inc. Termination of the manufacturing relationship with either of these
manufacturers could significantly and adversely affect our ability to produce
and sell our products. Though alternate sources of supply exist and new
manufacturing relationships could be established, we would need to recover our
existing tools or have new tools produced. Establishing new manufacturing
relationships could involve significant expense and delay. Any curtailment or
interruptions of the supply, whether or


                                       6


not as a result of termination of the relationship, would increase our losses
or, if we have become profitable, reduce our profits.

      Possible product liability claims could impair our resources and
jeopardize our viability. We could be subject to claims for personal injury from
the use of our dental and medical products, although we have never been sued for
personal injury claims. We have liability insurance in the aggregate amount of
$2,000,000 with a per-occurrence limit of $1,000,000 which we believe is
adequate, although we cannot assure you that the insurance coverage will be
sufficient to pay such claims should they be made. A partially or completely
uninsured claim, if successful and of significant magnitude, could jeopardize
our viability.

      Limitation of director liability may prevent our recovery of damages from
our directors. Our Certificate of Incorporation provides that our directors are
not personally liable to us or any of our stockholders for monetary damages for
breach of the fiduciary duty of care as a director, including breaches which
constitute gross negligence, subject to the limitations imposed by the Delaware
General Corporation Law. Thus, in some instances, neither we nor our
stockholders can recover damages even if directors take actions which harm us.

      Our presence in a highly competitive industry reduces our chances of
success. We face intense competition from many companies in the medical and
dental device industry, including well-established academic institutions
possessing substantially greater financial, marketing, personnel, and other
resources. Most of our competitors have established reputations, stemming from
their success in the development, sale, and service of competing dental
products. Further, our ability to compete successfully, requires that we
establish an effective distribution network. We cannot assure you that we can
compete successfully.

      Technological changes and new products may make our product obsolete. New
or enhanced products may contain features that render our products less
marketable, or even obsolete. In February 2001, a division of Dentsply unveiled
its own "Computer Controlled Anesthetic Delivery System". Milestone has not
completely assessed the competition presented by the product but believes that
the introduction of the Dentsply product serves to validate the technology
implicit in the CompuDent and CompuMed. Therefore, we must devote substantial
efforts and financial resources to enhance our existing products, to bring our
products to market quickly, and to develop new products for related markets. Our
industry is characterized by rapid technological change and research. New
products must be approved by regulatory authorities before they may be marketed.
We cannot assure you that we can compete successfully, that our competitors will
not develop technologies or products that render our products less marketable or
obsolete, or that we will succeed in improving our existing products,
effectively develop new products, or obtain required regulatory approval for
those products.

      Reliance Upon Management. We depend on the personal efforts and abilities
of Leonard Osser, our Chairman and Chief Executive Officer. While we have a key
man life insurance policy in the amount of $1,000,000 on the life of Mr. Osser,
any loss of his services could have a materially adverse effect on our business.

      If We Are Unable to Satisfy the American Stock Exchange Maintenance
Requirements, Our Common Stock May Be Delisted from the American Stock Exchange
and as a result, our Liquidity and the Value of our Common Stock May be
Impaired. Shares of our common stock are currently listed on the American Stock
Exchange. Continued listing on the American Stock Exchange requires that we
maintain at least $6,000,000 in stockholders' equity since we have sustained
losses in our five most recent fiscal years. At December 31, 2002,


                                       7


Milestone had a total stockholders' deficit of approximately $6.1 million. On
May 2, 2002, we received a letter from the American Stock Exchange advising us
that we have fallen below the stockholders' equity criterion and requesting that
we submit a recovery plan detailing any actions taken, or planned to be taken
within the next 18 months to bring the Company into compliance. On June 10, 2002
we submitted a detailed recovery plan to the American Stock Exchange which, as
supplemented on August 14, 2002, showed how we expect to achieve stockholder
equity of $6,000,000 by December 31, 2003. On August 23, 2002, the American
Stock Exchange advised us that they had determined that the plan makes a
reasonable demonstration of Milestone's ability to regain compliance with the
continued listing standards by the conclusion of the plan period at the end of
2003. The continued listing of our securities on the American Stock Exchange
during this period is subject to periodic reviews by the Exchange. Failure to
show progress consistent with the plan or to regain compliance by the end of the
plan period could still result in the Milestone being delisted. In the event
that our securities are delisted from the American Stock Exchange, trading, if
any, in the common stock and warrants would be conducted in the over the counter
market in the so-called "pink sheets" or on the NASD's "OTC Bulletin Board."
Consequently, the liquidity of our securities could be impaired, not only in the
number of securities which could be bought and sold, but also through delays in
the timing of transactions, reduction in security analysts and new media
coverage of Milestone, and lower prices for our securities than might otherwise
be obtained.

      If Our Shares of Common Stock Are Removed or Delisted from The American
Stock Exchange, the Ability of Stockholders to Sell Our Common Stock and
Warrants in the Secondary Market Could Be Restricted. The Securities and
Exchange Commission has adopted regulations which generally define "penny stock"
to be an equity security that has a market price, as defined, of less than $5.00
per share or an exercise price of less than $5.00 per share, subject to certain
exceptions, including an exception of an equity security that is quoted on the
American Stock Exchange. If our shares of common stock are removed or delisted
from the American Stock Exchange, they may become subject to rules that impose
additional sales practice requirements on broker-dealers who sell these
securities. For transactions covered by these rules, the broker-dealer must make
a special suitability determination for the purchaser of such securities and
have received the purchaser's written consent to the transactions prior to the
purchase. Additionally, for any transaction involving a penny stock, unless
exempt, the rules require the delivery, prior to the transaction, of a
disclosure schedule prepared by the Securities and Exchange Commission relating
to the penny stock market. The broker-dealer also must disclose the commissions
payable to both the broker-dealer and the registered underwriter, current
quotations for the securities and, if the broker-dealer is the sole market
maker, the broker-dealer must disclose this fact and the broker-dealer's
presumed control over the market. Finally, among other requirements, monthly
statements must be sent disclosing recent price information for the penny stock
held in the account and information on the limited market in penny stocks. As
such, the "penny stock" rules, in the event our securities are delisted from the
American Stock Exchange, may restrict the ability of stockholders to sell our
common stock and warrants in the secondary market.

      The price of our common stock may be adversely affected by the issuance of
shares of our common stock under the equity line of credit agreement. We may
sell up to 2,100,000 shares of our common stock to Hillgreen under the equity
line of credit agreement. The price of our common stock may decrease as a result
of the actual or potential sale of these shares into the market. In that event,
not only would you lose a portion of your investment, but we would probably find
it more difficult to obtain additional financing.


                                       8


      Our stockholders may experience significant dilution as a result of stock
issuances under the equity line of credit agreement. We will sell shares of our
common stock to Hillgreen under the equity line of credit agreement at a price
that is below the market price of our stock at the time of the sale. These sales
will dilute the interests of our existing stockholders. In addition, as the
price of our common stock decreases, we will be required to issue more shares of
our common stock for any given dollar amount invested by Hillgreen. The more
shares that are issued under the equity line of credit, the more our shares will
be diluted and the more our stock price may decrease. This may encourage short
sales, which could place further downward pressure on the price of our common
stock. Furthermore, for the life of any outstanding options and warrants, the
holders will have the opportunity to profit from a rise in the price of the
underlying common stock. When the holders of these options and warrants exercise
their rights to acquire shares of our common stock, the interests of the other
stockholders will be diluted. In addition, the holders of options and warrants
can be expected to exercise their options and warrants at a time when we would,
in all likelihood, be able to obtain additional capital by an offering of our
unissued common stock on terms more favorable to us than those provided by the
options or warrants.



                                       9


                SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

      We have made forward-looking statements in this prospectus and in the
documents that are incorporated by reference in this prospectus, all of which
are subject to risks and uncertainties. Forward-looking statements include
information concerning our possible or assumed future results of operations.
Also, when we use words such as "believe," "expect," "anticipate" or similar
expressions, we are making forward-looking statements. You should note that an
investment in our common stock involves certain risks and uncertainties that
could affect our future financial results. Our actual results could differ
materially from those anticipated in these forward-looking statements as a
result of certain factors, including those set forth in "Risk Factors" and
elsewhere in this prospectus.

      We believe it is important to communicate our expectations to our
investors. However, there may be events in the future that we are not able to
predict accurately or over which we have no control. The risk factors described
in the preceding pages, as well as any cautionary language in this prospectus,
provide examples of risks, uncertainties and events that may cause our actual
results to differ materially from the expectations we describe in our
forward-looking statements. Before you invest in our common stock, you should be
aware that the occurrence of the events described in these risk factors and
elsewhere in this prospectus could materially and adversely affect our business,
operating results and financial condition.

                                 USE OF PROCEEDS

      We will not receive any proceeds from the sale of shares by the selling
stockholders. However, we will receive the proceeds from any sale of common
stock to Hillgreen under the equity line of credit agreement described in this
prospectus and upon the exercise of warrants held by Hillgreen and Jesup &
Lamont when, and if, they exercise such warrants. We would realize proceeds of
approximately $1,772,122, based on the following expenses and assumptions:

      o     Effect is given to the discount to market price that will be paid by
            Hillgreen;

      o     Our expenses in connection with this offering, which we estimate to
            be $170,895.13, including the legal fees we paid to Hillgreen's
            counsel, Epstein Becker & Green P.C., to cover its legal and
            administrative expenses;

      o     Brokerage fees payable to Jesup & Lamont;

      o     An average volume weighted average price of $.92418 (based on daily
            closing prices of the common stock on American Stock Exchange from
            April 16, 2001 through April 20, 2001);

      o     We use the entire line of credit; and

      o     All of the warrants are exercised at $1.86.

      In addition, a portion of the proceeds from the initial drawdown under the
equity line of credit, if and when made, may be used to pay the expenses of this
offering. Since we do not know the number of drawdowns which will be made,
expenses do not cover the closing costs associated with each drawdown.


                                       10


      We expect to use substantially all the net proceeds for general corporate
purposes, including working capital, debt repayment and the launching of our
medical operation including clinical trials.

                           PRICE RANGE OF COMMON STOCK

      Our common stock is quoted on the American Stock Exchange under the symbol
"MS". The following table sets forth the range of high and low sales prices per
share of our common stock as reported on the American Stock Exchange for the
last two years and the interim period this year.

                                               Low               High
                                               ---               ----
2001
First Quarter                                  $ .80             $2.25
Second Quarter                                  . 60              1.09
Third Quarter                                  $1.75             $ .68
Fourth Quarter                                 $ .73             $ .50

2002
First Quarter                                  $ .68             $ .52
Second Quarter                                 $1.00             $ .58
Third Quarter                                  $ .68             $ .29
Fourth Quarter                                 $ .40             $ .21

2003
First Quarter                                  $ .34             $ .14
Second Quarter                                 $ .17             $ .40

      Based on information supplied by our transfer agent, as of August 31,
2003, we believe that there were approximately 150 record holders of our common
stock. On September 15, 2003, the closing price of our common stock was $1.66.

      The shares sold by the selling stockholders will be sold on the American
Stock Exchange or otherwise at prices related to the then current market price,
or in negotiated private transactions, or in a combination of these methods. The
selling stockholders will act independently of us in making decisions with
respect to the form, timing, manner and size of each sale.

                                 DIVIDEND POLICY

      We have never declared or paid any dividends to the holders of our common
stock and we do not expect to pay cash dividends in the foreseeable future. We
currently intend to retain all earnings for use in connection with the expansion
of our business and for general corporate purposes. Our board of directors has
sole discretion in determining whether to declare and pay dividends in the
future. The declaration of dividends will depend on our profitability, financial
condition, cash requirements, future prospects and other factors deemed relevant
by our board of directors. Our ability to pay cash dividends in the future could
be limited or prohibited by financing agreements that we may enter into or by
the terms of any preferred stock that we may authorize and issue.


                                       11


                                 CAPITALIZATION

      The following table sets forth our capitalization as of June 30, 2003 on
an actual basis. The table does not give effect to our sale and issuance of
shares of common stock under the equity line of credit or upon the exercise of
any stock purchase warrants held by Hillgreen and Jesup & Lamont. This table
should be read in conjunction with financial statements and the notes thereto
included or incorporated by reference in this prospectus.

                                                             As of June 30, 2003
                                                                 (unaudited)
                                                             -------------------
Long Term Debt                                                  $  1,354,761
                                                                ------------

Stockholders' equity:

     Common Stock, par value $.001 per share;
         authorized  50,000,000 shares; 12,733,370
         issued                                                 $     12,733

     Additional paid-in capital                                   36,614,029

     Accumulated earnings (deficit)                              (42,945,569)

     Unearned Compensation                                           (20,000)

     Treasury stock, at cost, 100,000 shares                        (911,516)
                                                                ------------

     Total stockholder's deficiency                             $ (7,250,323)
                                                                ------------
     Total capitalization                                       $ (5,895,562)
                                                                ============


                                       12


                         EQUITY LINE OF CREDIT AGREEMENT

Overview

      On January 19, 2001, we entered into an equity line of credit agreement
with Hillgreen Investments Limited, a British Virgin Islands corporation, in
order to establish a source of funding for working capital, launching our
medical operation, including clinical trials, and debt repayment. The equity
line of credit agreement establishes what is sometimes also referred to as an
equity drawdown facility.

      Under the equity line of credit agreement, Hillgreen has agreed to
purchase up to 2,100,000 shares of our common stock during the 36 month period
following the effective date of the registration statement to which this
prospectus relates. During this 36 month period, we may request a drawdown under
the equity line of credit by selling ("putting") shares of our common stock to
Hillgreen, and Hillgreen will be obligated to purchase the shares we put to it.
During the 20 business days following a drawdown notice, we will calculate the
number of shares we will sell to Hillgreen and the price per share.

      Upon the exercise of each drawdown, we will receive the amount of the
drawdown less a fee payable to legal counsel for Hillgreen and less a brokerage
fee payable to Jesup & Lamont.

The Drawdown Procedure and the Stock Purchases

      We may request a drawdown no more than once every 25 business days,
although we are under no obligation to do so, by faxing or otherwise delivering
a drawdown notice to Hillgreen, stating the amount of the drawdown we wish to
exercise.

      Amount of the Drawdown

      The minimum amount we can draw down at any one time is $50,000 worth of
common stock. The maximum amount we can draw down at any one time will be
determined at the time of the drawdown notice according to the following
formula:

      the lesser of

            (a)   $5,000,000, or

            (b)   fifteen percent (15%) of the volume weighted average price of
                  our common stock during the twenty (20) business days
                  immediately prior to the sale date, multiplied by the total
                  trading volume of the common stock during the twenty (20)
                  business days immediately prior to the sale date.

      Calculation of Purchase Price

      We may set a minimum threshold price for our common stock in each drawdown
notice that we deliver to Hillgreen. On the day following the delivery of the
drawdown notice, a valuation period of 20 business days will start. The price
per share ("Purchase Price") of common stock sold to Hillgreen will be
determined on each of the 20 business days following the delivery of the
drawdown notice as follows:

      o     On each business day during the valuation period where the daily
            volume weighted average price ("VWAP") of our common stock on the
            American Stock Exchange


                                       13


            equals or exceeds the threshold price, if any, set forth in the
            drawdown notice, the Purchase Price will equal 87.5% of the VWAP on
            such day.

      o     If the VWAP on a given day is less than the threshold price, or if
            trading of our common stock is suspended for more than three (3)
            hours, in the aggregate, on any day during the valuation period,
            then that day will be withdrawn from the valuation period and the
            amount of the drawdown will be reduced by 1/20.

      Number of Shares Issued

      The number of shares to be issued to Hillgreen will be determined on a
daily basis during each valuation period by dividing 1/20th of the drawdown
amount by 87.5% of the VWAP for that business day during the valuation period,
subject to the adjustments described elsewhere in this prospectus. The sum of
the quotients for the first through the tenth business days will be the number
of shares issued to Hillgreen on or prior to the twelfth day and the sum of the
quotients for each of the eleventh through the twentieth business days will be
issued to Hillgreen on the twenty-second day.

      If we set a threshold price too high and our stock price does not meet
that level during the 20 business days after our drawdown request, the amount we
can draw and the number of shares we sell to Hillgreen will be reduced. On the
other hand, if we set a threshold price too low and our stock price falls
significantly but stays above the threshold price, we will have to issue a
greater number of shares to Hillgreen at the reduced price.

      Payment for Shares Issued

      The shares purchased on the first 10 business days will be issued and paid
for on or prior to the twelfth business day following the drawdown request. The
shares purchased on the eleventh through the twentieth business days will be
issued and paid for on the twenty-second business day following the drawdown
request. We will receive the purchase price less a legal fee payable to counsel
for Hillgreen, and less a brokerage fee payable to Jesup & Lamont.

Investor Warrants

      At the closing of the equity line agreement, we issued to Hillgreen
100,000 warrants to purchase one share of our common stock. The warrants are
exercisable at any time, in whole or in part, during the three year period
commencing on January 22, 2001 at an exercise price of $1.86.


                                       14


Sample drawdown calculation

      The following is an example of the number of shares we would issue to
Hillgreen if we had given a drawdown notice on December 12, 2000, indicating a
drawdown amount of $90,000 and a minimum threshold price of $1.00 per share:



--------------------------------------------------------------------------------------------------
                                       Greater of
                                       VWAP or TP
                            Threshold  (0 if VWAP                                        No. of
                            Price      is less than   Purchase Price                     Shares
Trading Date     VWAP       (TP)       TP)            (after discount)    Principal      Purchased
--------------------------------------------------------------------------------------------------
                                                                      
1.   12/13/00    $1.3589    $1.00      $1.3589        $1.1890             $ 4,000        3,364
2.   12/14/00    $1.3696    $1.00      $1.3696        $1.1984             $ 4,000        3,338
3.   12/15/00    $1.3332    $1.00      $1.3332        $1.1666             $ 4,000        3,429
4.   12/18/00    $1.3125    $1.00      $1.3125        $1.1484             $ 4,000        3,483
5.   12/19/00    $1.2406    $1.00      $1.2406        $1.0855             $ 4,000        3,685
6.   12/20/00    $1.1470    $1.00      $1.1470        $1.0036             $ 4,000        3,986
7.   12/ 21/00   $1.0171    $1.00      $1.0171        $0.8900             $ 4,000        4,494
8.   12/22/00    $1.0270    $1.00      $1.0270        $0.8986             $ 4,000        4,451
9.   12/26/00    $0.9959    $1.00      $     0        N/A                 $     0            0
10.  12/27/00    $1.0547    $1.00      $1.0547        $0.9229             $ 4,000        4,334

--------------------------------------------------------------------------------------------------
Settlement on Day 12                                                      $36,000       34,564
--------------------------------------------------------------------------------------------------
11.  12/28/00    $1.1158    $1.00      $1.1158        $0.9763             $ 4,000        4,097
12.  12/29/00    $1.1952    $1.00      $1.1952        $1.0458             $ 4,000        3,825
13.  01/02/01    $1.5018    $1.00      $1.5018        $1.3141             $ 4,000        3,044
14.  01/03/01    $1.6834    $1.00      $1.6834        $1.4730             $ 4,000        2,716
15.  01/04/01    $2.0638    $1.00      $2.0638        $1.8058             $ 4,000        2,215
16.  01/05/01    $1.8295    $1.00      $1.8295        $1.6008             $ 4,000        2,499
17.  01/08/01    $1.5759    $1.00      $1.5759        $1.3789             $ 4,000        2,901
18.  01/09/01    $1.7139    $1.00      $1.7139        $1.4997             $ 4,000        2,667
19.  01/10/01    $1.6845    $1.00      $1.6845        $1.4739             $ 4,000        2,714
20.  01/11/01    $1.8285    $1.00      $1.8285        $1.5999             $ 4,000        2,500
--------------------------------------------------------------------------------------------------
Settlement on Day 22                                                      $40,000       29,178

Totals                                                                    $76,000       63,742

Less broker's (Jesup & Lamont) commission of 4.75%                          3,610

Less $500 fee to Hillgreen's counsel
   (Epstein, Becker & Green, P.C.)                                            500
                                                                         --------

Net proceeds to Milestone                                                 $71,890
                                                                         ========


Initial Closing Costs, Grant of Warrants and Costs of Closing Each Drawdown

      At the closing of the equity line of credit on January 22, 2001, we paid
$15,000 to Hillgreen's legal counsel, Epstein Becker & Green P.C., to cover its
legal and administrative expenses.

      As consideration for the opening of the equity line of credit, we granted
to Hillgreen warrants to purchase 100,000 shares of common stock. In addition,
as consideration for the services rendered by Jesup & Lamont as placement agent
in connection with this offering, we granted to Jesup & Lamont warrants to
purchase 75,000 shares of common stock. These warrants will be exercisable at
any time prior to January 22, 2003, at a price of $1.86 per share of common
stock. Neither Hillgreen nor Jesup & Lamont will be obligated to exercise the
warrants and to purchase any shares of common stock under the warrants.

      Lastly, upon the receipt of each drawdown amount from Hillgreen, we will
pay to Epstein, Becker & Green, legal counsel to Hillgreen, a fee of $500, and
to Jesup & Lamont Securities


                                       15


Corporation a brokerage fee equal to 4.75% of the aggregate purchase price for
each drawdown for the initial $4,000,000 received, 4.50% of the aggregate
purchase price for each drawdown for the following $4,000,000 received, and
4.25% of the aggregate purchase price for each drawdown thereafter. Jesup &
Lamont is the placement agent which introduced Hillgreen to us and is a
registered broker-dealer.

Necessary Conditions Before Hillgreen is Obligated to Purchase Our Shares

      The following conditions must be satisfied before Hillgreen is obligated
to purchase the common stock under a drawdown notice:

      o     A registration statement for the shares must be effective and
            available on each drawdown settlement date so that Hillgreen may
            freely sell the shares of common stock it purchases;

      o     All our representations and warranties to Hillgreen set forth in the
            equity line of credit agreement must be true and correct in all
            material respects;

      o     We will have made reasonable efforts to obtain all permits and
            qualifications required by any state blue sky laws in the states
            reasonably requested by Hillgreen;

      o     We have delivered into escrow or to the Depository Trust Company
            ("DTC") the shares of common stock being purchased;

      o     We have delivered to our transfer agent instructions reasonably
            satisfactory to Hillgreen;

      o     We have satisfied all laws and regulations pertaining to the sale
            and issuance of the shares of common stock to Hillgreen;

      o     We have performed, satisfied and complied in all material respects
            with all covenants, agreements and conditions required by the
            private equity line of credit agreement, registration rights
            agreement and escrow agreement, to be performed, satisfied or
            complied with by us;

      o     No statute, rule, regulation, executive order, decree, ruling or
            injunction may be in effect which prohibits consummation of the
            transactions contemplated by the equity line of credit agreement;

      o     No litigation or proceeding nor any investigation by any
            governmental authority can be pending which prohibits or adversely
            affects the consummation of the transactions contemplated by the
            equity line of credit agreement;

      o     Since the date of filing of our most recent SEC Document (including
            an annual, quarterly or current report), no event that had or is
            reasonably likely to have a "Material Adverse Effect" has occurred
            (a "Material Adverse Effect" means any effect on the business,
            operations, properties, prospects, or financial condition of the
            Company that is material and adverse to the Company and its
            subsidiaries and affiliates, taken as a whole, and/or any condition,
            circumstance, or situation


                                       16


            that would prohibit or otherwise interfere with the ability of the
            Company to enter into and perform any of its obligations under this
            Agreement, the Registration Rights Agreement or the Escrow Agreement
            in any material respect; provided, however, continued losses from
            operations consistent with prior quarters shall not, in and of
            themselves, constitute a Material Adverse Effect;

      o     Trading in our common stock must not have been suspended by the SEC
            or the American Stock Exchange, and our common stock continues to be
            listed on the American Stock Exchange;

      o     We will have delivered an opinion of our counsel described in the
            equity line of credit agreement regarding the validity of shares and
            the matters listed above;

      o     Five (5) business days have elapsed since the last valuation period;
            and

      o     Hillgreen has received and is reasonably satisfied with other
            standard closing documents as they may reasonably request to confirm
            the Company's compliance with foregoing conditions.

      In addition, we may not issue any shares of common stock under the equity
line of credit if the issuance results in Hillgreen beneficially owning more
than 9.9% of our then outstanding common stock. Since any resales of shares by
Hillgreen would reduce the number of shares beneficially owned by Hillgreen,
resales would enable us to issue additional shares to Hillgreen without
violating this condition.

      The listing requirements of the American Stock Exchange also prohibit us
from issuing 20% or more of our issued and outstanding shares of common stock at
a price less than the greater of market value or book value, unless we obtain
stockholder approval.

Restrictions on Future Financings

      The equity line of credit agreement limits our ability to raise money by
selling our securities to third parties at a discount to the market price during
the term of the equity line of credit agreement. There are exceptions to this
limitation for securities sold in the following situations:

      o     under any presently existing or future employee benefit plan, which
            plan has been or may be approved by our stockholders;

      o     under any compensatory plan for a full-time employee or key
            consultant;

      o     under an underwritten registered public offering;

      o     in connection with a strategic partnership or other business
            transaction, the principal purpose of which is not to raise money;

      o     under any option, warrant or agreement outstanding on the date of
            the agreement;


                                       17


      o     to any of the Company's officers, directors or existing holders of
            5% or more of the Common Stock or any of their affiliates, of up to
            $5,000,000 of securities, in the aggregate, in any financing or
            series of related financings; or

      o     with the prior approval of the Investor, which will not be
            unreasonably withheld or delayed.

Termination of the Equity Line of Credit Agreement

      The equity line of credit shall terminate if any stop order or suspension
of the effectiveness of the registration statement issues for an aggregate of
thirty (30) business days during the 36 month term of the equity line of credit
agreement, with some exceptions.

      We may terminate the equity line of credit agreement if Hillgreen ever
fails to honor one drawdown notice within ten (10) business days or more than
one drawdown notice within two (2) business days of the closing date scheduled
for such drawdown, and we notify Hillgreen of such termination. Upon
termination, we must maintain the registration statement in effect for such
reasonable period, not to exceed forty-five (45) days, as Hillgreen may request
to enable Hillgreen to dispose of any remaining drawndown shares.

Indemnification of Hillgreen

      Hillgreen is entitled to customary indemnification from us for any losses
or liabilities suffered by it based upon material misstatements or omissions
from the registration statement and this prospectus, except as they relate to
information supplied by Hillgreen to us for inclusion in the registration
statement and prospectus.


                                       18


                              SELLING STOCKHOLDERS

Overview

      The 2,275,000 shares of common stock registered for resale under this
prospectus include 2,100,000 shares issuable under the equity line of credit
agreement, 100,000 shares issuable upon the exercise of warrants granted to
Hillgreen and 75,000 shares issuable upon the exercise of warrants granted to
Jesup & Lamont. Because we do not know for certain how or when the selling
stockholders will choose to sell their shares of common stock, we cannot
estimate the amount of securities that will actually be offered for sale by the
selling stockholders. There can be no assurance that they will sell any or all
of the securities covered by this prospectus.

Hillgreen Investments Limited

      Hillgreen Investments Limited is a British Virgin Islands corporation
engaged in the business of investing in publicly traded equity securities for
its own account. Hillgreen's office is located at c/o Mishon deReya Solicitors,
21 Southampton Row, London WC1B 5HS England Attention: Kevin Gold. Investment
decisions for Hillgreen are made by its board of directors. Other than the
100,000 warrants we granted to Hillgreen in connection with closing the equity
line of credit agreement, Hillgreen does not currently own any of our
securities. Other than its obligation to purchase shares of common stock under
the equity line of credit agreement, Hillgreen has no other commitments or
arrangements to purchase or sell any of our securities. There are no business
relationships between Hillgreen and us other than the equity line of credit
agreement.

Jesup & Lamont Securities Corporation

      Jesup & Lamont Securities Corporation has acted as placement agent in
connection with the equity line of credit agreement. Jesup & Lamont introduced
us to Hillgreen and assisted us in structuring the equity line of credit with
Hillgreen. Jesup & Lamont's duties as placement agent were undertaken on a
reasonable best efforts basis only. It made no commitment to purchase shares
from us and did not ensure us of the successful placement of any securities.

      Other than the warrants granted to Jesup & Lamont as a placement fee,
Jesup & Lamont does not currently own any of our securities. The decision to
exercise any warrants granted to Jesup & Lamont, and the decision to sell the
common stock issued upon the exercise of the warrants, will be made by Jesup &
Lamont's officers and board of directors.

      The selling stockholders have not held any positions or offices or had
material relationships with us or with any of our affiliates within the past
three years other than as a result of the ownership of our common stock. If, in
the future, the selling stockholders' relationship with us changes, we will
amend or supplement this prospectus to update this disclosure.

                              PLAN OF DISTRIBUTION

General

      Hillgreen or an affiliate, and Jesup & Lamont may offer for sale up to
2,275,000 shares of our common stock, which they will originally acquire under
the terms of the equity line of credit agreement and the warrants that we issued
to them. Hillgreen and Jesup & Lamont will be offering such


                                       19


shares for their own account. We do not know for certain how or when the selling
stockholders will choose to sell their shares of common stock. We will not
receive any proceeds from the sale of shares of common stock by the selling
stockholders.

      To permit Hillgreen and Jesup & Lamont to resell the shares of common
stock issued to them, we agreed to file with the SEC a registration statement
and all necessary amendments and supplements thereto for the purpose of
registering and maintaining the registration of the shares. We will bear all
costs relating to the registration of the common stock offered by the
prospectus. We will keep the registration statement effective until the earliest
of any of the following dates:

      o     the date after which none of the shares of common stock held by
            Hillgreen that are covered by the registration statement are or may
            become issued and outstanding;

      o     the date after which all of the shares of common stock held by
            Hillgreen have been transferred to persons who may trade such shares
            without restriction under the Securities Act of 1933 and we have
            delivered new certificates or other evidences of ownership of such
            shares without any restrictive legend;

      o     the date after which all of the shares of common stock held by
            Hillgreen that are covered by the registration statement have been
            sold by Hillgreen under the registration statement;

      o     the date that Hillgreen or its transferees receive an opinion of our
            counsel that their shares of common stock may be sold under the
            provisions of Rule 144 promulgated under the Securities Act without
            any applicable volume limitations;

      o     the date after which all of the shares of common stock held by
            Hillgreen may be sold, in the opinion of our counsel, without any
            time, volume or manner limitations under Rule 144(k) promulgated
            under the Securities Act of 1933; or

      o     if Hillgreen ever fails to honor one drawdown notice within ten (10)
            business days or more than one drawdown notice within two (2)
            business days of the closing date scheduled for such drawdown, and
            we elect to terminate the equity line of credit agreement, we must
            maintain the registration statement in effect for a reasonable
            period of time, not to exceed forty-five (45) days, as Hillgreen may
            request in order to dispose of any remaining drawndown shares.

      The selling stockholders will offer our common stock into the public
market using this prospectus or under Rule 144 instead of under this prospectus,
if they qualify. Shares of common stock offered through this prospectus or under
Rule 144 may be sold from time to time by Hillgreen and Jesup & Lamont, although
there can be no assurance that they will in fact sell any or all of the
securities covered by this prospectus. These sales may be made on the American
Stock Exchange, or otherwise, at prices related to the then current market
price, or in negotiated private transactions, or in a combination of these
methods. The selling stockholders will act independently of us in making
decisions with respect to the form, timing, manner and size of each sale. We
have been informed by the selling stockholders that there are no existing
arrangements between them and any other stockholder, broker, dealer, underwriter
or agent relating to the sale or distribution of shares of common stock which
may be sold by them through this prospectus.


                                       20


      The shares of common stock may be sold in one or more of the following
manners:

      o     block trades in which the broker or dealer so engaged will attempt
            to sell the shares as agent, but may position and resell a portion
            of the block as principal to facilitate the transaction;

      o     purchases by a broker or dealer for its account under this
            prospectus; or

      o     ordinary brokerage transactions and transactions in which the broker
            solicits purchases.

      The selling stockholders will pay all commissions and their own expenses,
if any, associated with the sale of the shares of common stock. Sales by the
selling stockholders will be without the payment of any underwriting discounts
or commissions, except for usual and customary selling commissions paid to
brokers or dealers. However, in effecting sales, brokers or dealers engaged by
the selling stockholders may arrange for other brokers or dealers to
participate. Except as disclosed in a supplement to this prospectus, no
broker-dealer will be paid more than a customary brokerage commission in
connection with any sale of the shares of common stock by the selling
stockholders. Brokers or dealers may receive commissions, discounts or other
concessions from the selling stockholders in amounts to be negotiated
immediately prior to the sale. The compensation to a particular broker-dealer
may be in excess of customary commissions. Profits on any resale of the shares
of common stock as a principal by such broker-dealers and any commissions
received by such broker-dealers may be deemed to be underwriting discounts and
commissions under the Securities Act of 1933. Any broker-dealer participating in
the transactions as agent may receive commissions from the selling stockholders
(and, if they act as agent for the purchaser of such shares of common stock,
from such purchaser).

      Broker-dealers may agree with the selling stockholders to sell a specified
number of shares of common stock at a stipulated price per share and, to the
extent a broker-dealer is unable to do so acting as agent for the selling
stockholders, to purchase as principal any unsold shares of common stock at a
price required to fulfill the broker-dealer commitment to the selling
stockholders. Broker-dealers who acquire shares of common stock as principal may
thereafter resell those shares of common stock from time to time in transactions
(which may involve crosses and block transactions and which may involve sales to
and through other broker-dealers, including transactions of the nature described
above) in the over-the-counter market, in negotiated transactions or otherwise
at market prices prevailing at the time of sale or at negotiated prices, and in
connection with the resales may pay to or receive from the purchasers of the
shares of common stock commissions computed as described above. Brokers or
dealers who acquire shares of common stock as principal and any other
participating brokers or dealers may be deemed to be underwriters in connection
with resales of the shares of common stock.

      Hillgreen is a statutory underwriter within the meaning of Section 2(11)
of the Securities Act of 1933 with respect to any shares sold by it. Hillgreen
has agreed to be named as a statutory underwriter and will be acting as an
underwriter in its resales of the shares of common stock under this prospectus.
Because Hillgreen is a statutory underwriter, the discounts and concessions it
receives upon purchases of our common stock, and any profits it receives on the
resale of the shares, will be deemed to be underwriting discounts and
commissions under the Securities Act. Each time Hillgreen purchases shares of
our common stock under the equity line of credit agreement, it will receive a
12.5% discount to the daily volume weighted average prices of our common stock
on the American Stock Exchange during the twenty (20) business days following a
drawdown notice. Assuming a volume weighted average price of $.92418 (based on


                                       21


recent daily closing prices of the common stock on American Stock Exchange from
April 16, 2001 through April 20, 2001), and assuming we use the entire line of
credit and issue all 2,100,000 shares registered for issuance under the equity
line of credit agreement, Hillgreen will receive "underwriting compensation" in
the form of its discounted purchase price equal to $242,597.25, or approximately
$0.12 per share. In connection with the equity line of credit, we granted
100,000 warrants to Hillgreen, which are exercisable for $1.86 per share of
common stock at any time prior to January 22, 2004. The warrants granted to
Hillgreen will also be deemed to be underwriting commission under the Securities
Act. Lastly, at the closing of the equity line of credit agreement, we paid
legal fees to Hillgreen's counsel, Epstein Becker & Green P.C., to cover
Hillgreen's legal and administrative expenses.

      Hillgreen and Jesup & Lamont are also subject to applicable state and
federal securities laws, rules and regulations, including Rule 10b-5 and
Regulation M under the Exchange Act of 1934, and the rules and regulations of
the American Stock Exchange. These rules prohibit each selling stockholders
from:

      (1)   engaging in market making activities at the same time as it is
            engaged in a distribution of the shares of common stock for a period
            beginning when it becomes a distribution participant and ending upon
            its completion of participation in a distribution;

      (2)   engaging in any stabilization activity in connection with our
            securities;

      (3)   imposing penalty bids or effecting passive market making bids; and

      (4)   bidding for or purchasing any of our common stock or attempting to
            induce any person to purchase any of our common stock other than as
            permitted under the Exchange Act.

      In addition, any selling stockholders who may be "affiliated purchasers"
of us as defined in Regulation M, must coordinate their sales under this
prospectus with each other and with us for purposes of Regulation M as required
by Securities Exchange Act Release 34-38067 (December 20, 1996). None of the
selling stockholders has been an officer, director or otherwise an affiliate of
our company during the last three years. In addition to the rules and
regulations applicable to it, Hillgreen also has agreed not to engage in any
short sales of our common stock as long as the equity line of credit is active.
These restrictions, and the other rules and regulations applicable to the
selling stockholders, may affect the marketability of the shares of common
stock.

Limited Grant of Registration Rights

      We granted registration rights to Hillgreen to enable it to sell the
common stock it purchases under the equity line of credit agreement. In
connection with any such registration, we will have no obligation:

      o     to assist or cooperate with Hillgreen in the offering or disposition
            of the shares;

      o     to indemnify or hold harmless the holders of any of the shares
            (other than Hillgreen) or any underwriter designated by the holders;

      o     to obtain a commitment from an underwriter relative to the sale of
            any of the shares; or


                                       22


      o     to include the shares within any underwritten offering that we do.

      We will assume no obligation or responsibility whatsoever to determine a
method of disposition for the shares or to otherwise include the shares within
the confines of any registered offering other than the registration statement of
which this prospectus is a part.

      We will file one or more post-effective amendments to the registration
statement, of which this prospectus is a part, to describe any material change
to the information in this prospectus (including with respect to the plan of
distribution) for as long as Hillgreen holds shares of our stock or until the
shares can be sold under an appropriate exemption from registration. This
obligation may include, to the extent required under the Securities Act of 1933,
that a supplemental prospectus be filed, disclosing:

      o     the name of any broker-dealers;

      o     the number of shares of common stock involved;

      o     the price at which the shares of common stock are to be sold;

      o     the commissions paid or discounts or concessions allowed to
            broker-dealers, where applicable;

      o     that broker-dealers did not conduct any investigation to verify the
            information set out or incorporated by reference in this prospectus,
            as supplemented; and

      o     any other facts material to the transaction.

      Our registration rights agreement with Hillgreen permits us to restrict
the resale of the shares that Hillgreen has purchased from us under the equity
line of credit agreement for a period of time sufficient to permit us to amend
or supplement this prospectus to include material information. If we restrict
Hillgreen at any time within five business days of the closing of any drawdown
and our stock price declines during the restriction period, then we must issue
additional shares to Hillgreen to compensate it for the net decline in the value
of the shares it held during the restriction period or the shares that it
committed to purchase and purchased during the period. The number of shares that
we will issue to Hillgreen as compensation in these circumstances will equal the
product of:

            o     the number of shares sold by Hillgreen during the five (5)
                  business days immediately following the end of the applicable
                  restriction period, multiplied by

            o     the difference between the highest daily VWAP during the
                  applicable restriction period and the daily VWAP on the day
                  immediately following the end of that restriction period.

      If any such issuance would result in the issuance of a number of shares
which exceeds the number permitted under the equity line of credit agreement
(see "Equity Line of Credit Agreement--Necessary Conditions Before Hillgreen is
Obligated to Purchase Our Shares"), then in lieu of such issuance, we will pay
to Hillgreen an amount in cash equal to the closing ask price of the shares that
would have been issuable under the formula contained in the previous sentence.


                                       23


                          DESCRIPTION OF CAPITAL STOCK

      The following summary describes the material provisions of our capital
stock and is subject to, and qualified in its entirety by, our Certificate of
Incorporation, and amendments thereto, and our By-laws, all of which are
incorporated by reference as exhibits to the registration statement of which
this prospectus is a part and by provisions of applicable law.

      We are authorized to issue up to 50,000,000 shares of common stock, par
value $.001 and up to 5,000,000 shares of preferred stock, $.001 par value per
share. As of December 31, 2003, 12,633,370 shares of common stock were issued
and outstanding. To this date no shares of preferred stock have been issued. On
August 31, 2003, there were approximately 150 record holders of our common
stock, including several brokerage firms holding shares in street name for
beneficial owners.

Common Stock.

      All of our issued and outstanding shares of common stock are validly
issued, fully paid and non-assessable. All shares of our common stock to be
outstanding after this offering, when paid for and issued, will be validly
issued, fully paid and non-assessable.

      Voting Rights. Holders of our common stock are entitled to one vote per
share on all matters requiring a vote of the stockholders. Common stockholders
have no right to cumulative voting in the election of directors. Accordingly,
all of our directors can be elected by a plurality of votes cast at a meeting.

      Liquidation Rights. In the event of liquidation of our company, all
holders of our common stock will participate on an equal basis in the net assets
available for distribution after payment of our liabilities and payment of any
liquidation preferences in favor of outstanding shares of preferred stock, if
there are any.

      Dividend Rights. Holders of our common stock are entitled to receive
dividends in cash or property on an equal basis, if and when dividends are
declared by the board of directors on the common stock. It is our present
intention to retain our earnings, if any, for use in our business. Dividends
are, therefore, unlikely in the foreseeable future.

      Preemptive Rights and Redemption. The holders of our common stock have no
preemptive rights to maintain their respective percentage ownership interest in
our other securities. Our common stock is not redeemable or subject to further
calls or assessments.

Preferred Shares

      The Board of Directors, in the exercise of its discretion, is authorized
to issue the undesignated Preferred Stock in one or more series, to determine
the powers, preferences and rights, and qualifications, limitations or
restrictions, granted to or imposed upon any wholly unissued series of
undesignated Preferred Stock, and to fix the number of shares constituting any
series and the designation of such series, without any further vote or action by
the stockholders.


                                       24


Options and Warrants

      In 1997, our Board of Directors approved the adoption of our 1997 Stock
Option Plan. Under this plan, we are authorized to grant options to purchase a
maximum of 1,000,000 shares of common stock to our employees, including officers
and directors, at a price not less than the fair market value of the common
stock on the date of the grant. In general, options become exercisable over a
three-year period from the grant date and expire five years after the date of
grant.

      As of August 31, 2003, we have granted 663,344 compensatory options under
our stock option plan, and 336,656 options are available under the plan for
future grant. We have granted 387,500 options outside of the plan as
compensation to our non-employee directors and consultants at a weighted average
price of $2.00. All options have been granted at exercise prices equal to or
greater than fair market value at the time of grant. In addition, there are
1,934,970 warrants outstanding in connection with financing transactions at a
weighted average price of $.90.

      Holders of options and warrants do not have any of the rights or
privileges of our stockholders, including voting rights, prior to exercise of
the options and warrants. We have reserved sufficient shares of authorized
common stock to cover the issuance of common stock subject to the options and
warrants.

Section 203 of the Delaware General Corporation Law

      Section 203 of the Delaware General Corporation Law prohibits us from
engaging in a "business combination" with an "interested stockholder" for a
period of three years after the date of the transaction in which the person
became an interested stockholder, unless the transaction is approved in a
prescribed manner. As a result, potential acquirers may be discouraged from
attempting to effect acquisition transactions with us thereby possibly depriving
our stockholders of opportunities to sell or otherwise dispose of their
securities at above-market prices in these transactions.

      Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons under our
Certificate of Incorporation, Bylaws and the Delaware General Corporation Law,
we have been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy and is, therefore,
unenforceable.

Transfer Agent

      The transfer agent and registrar for our common stock is Continental Stock
Transfer & Trust Company, 2 Broadway, New York, New York 10004.

                       WHERE YOU CAN FIND MORE INFORMATION

      This prospectus is part of a registration statement on Form S-2 that we
have filed with the SEC. Parts of the registration statement have been omitted
from this prospectus as permitted by the rules and regulations of the SEC, and
this prospectus does not contain all of the information contained or
incorporated by reference in the registration statement. In particular,
statements in this prospectus concerning the terms of certain agreements and
other documents are necessarily summaries of those documents, and in each case
we refer you to the copy of the applicable


                                       25


document to the extent we have filed it as an exhibit to the registration
statement. For further information on us and the information in this prospectus,
we refer you to the registration statement and its exhibits. You may obtain
copies of the registration statement and its exhibits by paying a prescribed
fee, or you may examine them without charge, at the public reference facilities
maintained by the SEC at its office at Room 1024, 450 Fifth Street, N.W.,
Washington, D.C. 20549, as well as at the Regional Offices of the SEC at Seven
World Trade Center, New York, New York 10048 and Citicorp Center, 300 West
Madison Street, Chicago, Illinois 60661. You may obtain information on the
operation of the public reference facilities by calling the SEC at
1-800-SEC-0330. In addition, you may obtain copies of the registration statement
and its exhibits at the SEC's website located at http://www.sec.gov.

      We are a reporting company and file our annual, quarterly and current
reports, proxy material and other information with the Securities and Exchange
Commission. You may read and copy any materials that we file with the SEC at the
SEC's public reference facilities listed above, as well as on the SEC's website.

                    INCORPORATION OF INFORMATION BY REFERENCE

      The SEC allows us to "incorporate by reference" information that we file
with it, which means that we can disclose important information to you by
referring you to the documents filed with the SEC. The information incorporated
by reference is an important part of this prospectus. We incorporate our Annual
Report on Form 10-KSB for the fiscal year ended December 31, 2003, as filed on
April 15, 2003 and our quarterly reports for the first two quarters of 2003 on
Form 10-QSB, as filed on May 20, 2003 and August 19, 2003.

      A copy of our above mentioned Form 10-KSB is included with this
prospectus. If you need another copy of this document, we will provide you with
a free copy upon oral or written request. Requests should be directed to Thomas
M. Stuckey, Vice President and Chief Financial Officer, Milestone Scientific
Inc., 220 South Orange Avenue, Livingston, New Jersey 07039, telephone (973)
535-2717.

      In making a decision to buy our common stock, you should rely only on the
information incorporated by reference or contained in the prospectus. We have
not authorized anyone to provide you with different information. If anyone
provides you with different or inconsistent information, you should not rely on
it.

      You should assume that the information appearing in this prospectus is
accurate only as of the date on the front cover of this prospectus. Our
business, financial condition, results of operations and prospectus may have
changed since that date.

                                Material Changes

      On July 24, 2003, we amended our Certificate of Incorporation to increase
the total number of shares of common stock that the Company is authorized to
issue to 50,000,000 and to add 5,000,000 shares of a new class of preferred
stock to the authorized capital of the Company. The Board of Directors, in the
exercise of its discretion, is authorized to issue the undesignated Preferred
Stock in one or more series, to determine the powers, preferences and rights,
and qualifications, limitations or restrictions, granted to or imposed upon any
wholly unissued series of undesignated Preferred Stock, and to fix the number of
shares constituting any series and the designation of such series, without any
further vote or action by the stockholders.


                                       26


                                  LEGAL MATTERS

      Morse, Zelnick, Rose & Lander, LLP, 405 Park Avenue, New York, New York
10022 will deliver an opinion that the issuance of the shares covered by this
prospectus has been approved by our Board of Directors and that the shares, when
issued, will be fully paid and non-assessable under Delaware law. Morse,
Zelnick, Rose & Lander, LLP is the holder, in the aggregate, options or warrants
to purchase 118,000 shares of our common stock, all of which are currently
exercisable; and warrants to purchase 83,333 units, each unit consisting of one
share of our common stock and a warrant to purchase one share of our common
stock. Additional 200,000 of shares of common stock are held by a related party.

                                     EXPERTS

      The consolidated financial statements for the years ended December 31,
2001 and 2002, incorporated in this prospectus by reference, from the Milestone
Scientific Inc. Annual Report on Form 10-KSB filed April 15, 2003, have been
audited by J. H. Cohn LLP, independent public accountants, as stated in their
report which is incorporated herein by reference, and have been so incorporated
in reliance upon the report of such firm given upon their authority as experts
in accounting and auditing.


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                                2,275,000 Shares

                                     [LOGO]

                                  Common Stock

                                   PROSPECTUS

                                October 3, 2003


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