Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Noiman Silvia
   2. Issuer Name and Ticker or Trading Symbol
EPIX Pharmaceuticals, Inc. [EPIX] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Sr VP Pipeline Mgt, GM Israel
(Last)
(First)
(Middle)
C/O EPIX PHARMACEUTICALS, INC., 4 MAGUIRE ROAD		 3. Date of Earliest Transaction (Month/Day/Year)
08/16/2006
(Street)

LEXINGTON, MA 02421		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 08/16/2006   A   3,684 A (1) 3,684 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy) $ 2.18 08/16/2006   A   10,527     (2) 08/11/2013 Common Stock 10,527 (2) 10,527 D  
Stock Option (Right to Buy) $ 2.18 08/16/2006   A   5,045     (3) 08/11/2013 Common Stock 5,045 (3) 5,045 D  
Stock Option (Right to Buy) $ 2.18 08/16/2006   A   3,214     (4) 04/29/2014 Common Stock 3,214 (4) 3,214 D  
Stock Option (Right to Buy) $ 0.98 08/16/2006   A   95,315     (5) 09/23/2014 Common Stock 95,315 (5) 95,315 D  
Stock Option (Right to Buy) $ 0.98 08/16/2006   A   30,554     (6) 09/23/2014 Common Stock 30,554 (6) 30,554 D  
Stock Option (Right to Buy) $ 0.98 08/16/2006   A   74,092     (7) 01/18/2015 Common Stock 74,092 (7) 74,092 D  
Stock Option (Right to Buy) $ 1.74 08/16/2006   A   11,141     (8) 04/28/2015 Common Stock 11,141 (8) 11,141 D  
Stock Option (Right to Buy) $ 3.62 08/16/2006   A   24,800     (9) 06/05/2016 Common Stock 24,800 (9) 24,800 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Noiman Silvia
C/O EPIX PHARMACEUTICALS, INC.
4 MAGUIRE ROAD
LEXINGTON, MA 02421		       Sr VP Pipeline Mgt, GM Israel  

Signatures

 /s/ Michael Berdik Attorney-in-Fact   08/18/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Received in exchange for 4,457 shares of Predix Pharmaceuticals Holdings, Inc. ("Predix") common stock based on an exchange ratio of 0.826702 in connection with the merger of EPIX Pharmaceuticals, Inc. ("EPIX") and Predix (the "Merger") and after EPIX having effected a 1 for 1.5 reverse stock split. On the effective date of the Merger, the closing price of EPIX?s common stock was $4.85 per share.
(2) Received in the Merger in exchange for a stock option to acquire 12,735 shares of Predix common stock for $1.80 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option vests over a four year period at a rate of 25% on July 31, 2004, with the balance vesting in equal annual installments over the remaining three years.
(3) Received in the Merger in exchange for a stock option to acquire 6,104 shares of Predix common stock for $1.80 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option vested in full on August 8, 2003.
(4) Received in the Merger in exchange for a stock option to acquire 3,888 shares of Predix common stock for $1.80 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option began vesting in 16 quarterly installments of 6.25% each on July 29, 2004.
(5) Received in the Merger in exchange for a stock option to acquire 115,301 shares of Predix common stock for $0.81 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option vested in full on November 1, 2004.
(6) Received in the Merger in exchange for a stock option to acquire 36,962 shares of Predix common stock for $0.81 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option vested in full on November 1, 2004.
(7) Received in the Merger in exchange for a stock option to acquire 89,628 shares of Predix common stock for $0.81 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option began vesting in 48 approximately equal monthly installments on February 18, 2005.
(8) Received in the Merger in exchange for a stock option to acquire 13,478 shares of Predix common stock for $1.44 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option began vesting in 48 approximately equal monthly installments on August 1, 2005.
(9) Received in the Merger in exchange for a stock option to acquire 30,000 shares of Predix common stock for $2.99 per share. The terms and provisions of the Predix option plan under which this option was granted will continue to apply to this option. The option vested as to 10.4% of the shares as of June 5, 2006, with the remaining balance vesting in 43 approximately equal monthly installments beginning on July 1, 2006.

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