Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Sweeney Edward J
  2. Issuer Name and Ticker or Trading Symbol
ENDO PHARMACEUTICALS HOLDINGS INC [ENDP]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Principal Accounting Officer
(Last)
(First)
(Middle)
C/O ENDO PHARMACEUTICALS HOLDINGS INC., 100 ENDO BOULEVARD
3. Date of Earliest Transaction (Month/Day/Year)
03/03/2011
(Street)

CHADDS FORD, PA 19317
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, par value, $.01 per share 03/03/2011   M   1,292 A $ 16.47 1,292 D  
Common Stock, par value, $.01 per share 03/03/2011   S   1,292 D $ 36 (1) 0 D  
Common Stock, par value, $.01 per share 03/03/2011   M   6,339 A $ 28.61 6,339 D  
Common Stock, par value, $0.01 per share 03/03/2011   S   6,339 D $ 36.25 (1) 0 D  
Common Stock, par value, $0.01 per share 03/03/2011   M   4,612 A $ 30.55 4,612 D  
Common Stock, par value, $0.01 per share 03/03/2011   S   4,612 D $ 36.25 (1) 0 D  
Common Stock, par value, $0.01 per share 03/03/2011   M   5,068 A $ 25.19 5,068 D  
Common Stock, par value, $0.01 per share 03/03/2011   S   5,068 D $ 36 (1) 0 D  
Common Stock, par value, $0.01 per share 03/03/2011   M   5,760 A $ 19.93 5,760 D  
Common Stock, par value, $0.01 per share 03/03/2011   S   5,760 D $ 36 (1) 0 D  
Common Stock, par value, $0.01 per share 03/03/2011   M   3,319 A $ 20.61 3,319 D  
Common Stock, par value, $0.01 per share 03/03/2011   S   3,319 D $ 36 (1) 0 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
2000 Stock Incentive Plan Options $ 16.47 03/03/2011   M     1,292   (2) 08/11/2014 Common Stock 1,292 $ 0 (3) 0 D  
2004 Stock Incentive Plan Options $ 28.61 03/03/2011   M     6,339   (4) 02/14/2016 Common Stock 6,339 $ 0 (3) 0 D  
2000 Stock Incentive Plan Options $ 30.55 03/03/2011   M     4,612   (5) 02/21/2017 Common Stock 4,612 $ 0 (3) 0 D  
2007 Stock Incentive Plan Options $ 25.19 03/03/2011   M     5,068   (6) 02/21/2018 Common Stock 5,068 $ 0 (3) 1,689 D  
2007 Stock Incentive Plan Options $ 19.93 03/03/2011   M     5,760   (7) 02/26/2019 Common Stock 5,760 $ 0 (3) 5,760 D  
2007 Stock Incentive Plan Options $ 20.61 03/03/2011   M     3,319   (8) 02/19/2020 Common Stock 3,319 $ 0 (3) 9,957 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Sweeney Edward J
C/O ENDO PHARMACEUTICALS HOLDINGS INC.
100 ENDO BOULEVARD
CHADDS FORD, PA 19317
      Principal Accounting Officer  

Signatures

 /s/ Caroline B. Manogue, by Power of Attorney   03/07/2011
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This represents the average price that Mr. Sweeney's common shares were sold at on March 3, 2011.
(2) Mr. Sweeney's stock options that were granted under the 2000 Stock Incentive Plan on August 11, 2004 were exercisable 25% per year on each of August 11, 2005, August 11, 2006, August 11, 2007 and August 11, 2008. The 1,292 stock options that were exercised now are those that remained exercisable from Mr. Sweeney's original grant of 2,586 stock options.
(3) These securities were granted to Mr. Sweeney in consideration of his services as the Principal Accounting Officer of Endo Pharmaceuticals Holdings Inc.
(4) Mr. Sweeney's stock options that were granted under the 2004 Stock Incentive Plan on February 14, 2006 were exercisable 25% per year on each of February 14, 2007, February 14, 2008, February 14, 2009 and February 14, 2010. The 6,339 stock options that were exercised now represent all of the shares exercisable from Mr. Sweeney's original grant of 6,339 stock options.
(5) Mr. Sweeney's stock options that were granted under the 2000 Stock Incentive Plan on February 21, 2007 were exercisable 25% per year on each of February 21, 2008, February 21, 2009, February 21, 2010 and February 21, 2011. The 4,612 stock options that were exercised now represent all of the shares exercisable from Mr. Sweeney's original grant of 4,612 stock options, including those that became exercisable on February 21, 2011.
(6) Mr. Sweeney's stock options that were granted under the 2007 Stock Incentive Plan on February 21, 2008 are generally exercisable 25% per year on each of February 21, 2009, February 21, 2010, February 21, 2011 and February 21, 2012. The 5,068 stock options that were exercised now represent all of the shares exercisable from Mr. Sweeney's original grant of 6,757 stock options, including those that became exercisable on February 21, 2011.
(7) Mr. Sweeney's stock options that were granted under the 2007 Stock Incentive Plan on February 26, 2009 are generally exercisable 25% per year on each of February 26, 2010, February 26, 2011, February 26, 2012 and February 26, 2013. The 5,760 stock options that were exercised now represent all of the shares exercisable from Mr. Sweeney's original grant of 11,520 stock options, including those that became exercisable on February 26, 2011.
(8) Mr. Sweeney's stock options that were granted under the 2007 Stock Incentive Plan on February 19, 2010 are generally exercisable 25% per year on each of February 19, 2011, February 19, 2012, February 19, 2013 and February 19, 2014. The 3,319 stock options that were exercised now represent all of the shares exercisable from Mr. Sweeney's original grant of 13,276 stock options and are those shares that became exercisable on February 19, 2011.

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