Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Copeland Robert A
2. Date of Event Requiring Statement (Month/Day/Year)
05/30/2013
3. Issuer Name and Ticker or Trading Symbol
Epizyme, Inc. [EPZM]
(Last)
(First)
(Middle)
C/O EPIZYME, INC., 400 TECHNOLOGY SQUARE
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
EVP and CSO
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CAMBRIDGE, MA 02139
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 56,694 (1)
D
 
Common Stock 33,333 (1)
I
By Wife

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy)   (2) 03/17/2020 Common Stock 60,000 (1) $ 0.51 (1) D  
Stock Option (right to buy)   (3) 03/10/2021 Common Stock 109,764 (1) $ 0.6 (1) D  
Stock Option (right to buy)   (4) 10/02/2022 Common Stock 54,410 (1) $ 2.19 (1) D  
Stock Option (right to buy)   (5) 01/24/2023 Common Stock 94,000 (1) $ 3.54 (1) D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Copeland Robert A
C/O EPIZYME, INC.
400 TECHNOLOGY SQUARE
CAMBRIDGE, MA 02139
    X   EVP and CSO  

Signatures

/s/ Stephen Garbacz, attorney-in-fact 05/30/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Reflects a one-for-three reverse stock split effected on May 13, 2013.
(2) This option was granted on March 18, 2010 with respect to 60,000 shares of Common Stock, with 25% vesting on March 18, 2011 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter.
(3) This option was granted on March 11, 2011 with respect to 109,764 shares of Common Stock, with 25% vesting on March 11, 2012 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter.
(4) This option is fully vested.
(5) This option was granted on January 25, 2013 with respect to 94,000 shares of Common Stock, with 25% vesting on January 25, 2014 and the remaining 75% vesting in 36 substantially equal monthly installments thereafter.

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