PROSPECTUS FILED PURSUANT TO RULE 424(B)(3)

                       LIGAND PHARMACEUTICALS INCORPORATED

                                                FILED PURSUANT TO RULE 424(B)(3)
                                                     REGISTRATION NO. 333-131029

                           PROSPECTUS SUPPLEMENT NO. 6
    (TO PROSPECTUS DATED APRIL 12, 2006, AS SUPPLEMENTED AND AMENDED BY THAT
   PROSPECTUS SUPPLEMENT NO. 1 DATED MAY 15, 2006, THAT PROSPECTUS SUPPLEMENT
   NO. 2 DATED JUNE 12, 2006, THAT PROSPECTUS SUPPLEMENT NO. 3 DATED JUNE 29,
      2006, THAT PROSPECTUS SUPPLEMENT NO. 4 DATED AUGUST 4, 2006, AND THAT
                PROSPECTUS SUPPLEMENT NO. 5 DATED AUGUST 9, 2006)

         This Prospectus Supplement No. 6 supplements and amends the prospectus
dated April 12, 2006 (as supplemented and amended by that Prospectus Supplement
No. 1 dated May 15, 2006, that Prospectus Supplement No. 2 dated June 12, 2006,
that Prospectus Supplement No. 3 dated June 29, 2006, that Prospectus Supplement
No. 4 dated August 4, 2006, and that Prospectus Supplement No. 5 dated August 9,
2006), or the Prospectus, relating to the offer and sale of up to 7,790,974
shares of our common stock to be issued pursuant to awards granted or to be
granted under our 2002 Stock Incentive Plan, or our 2002 Plan, up to 147,510
shares of our common stock to be issued pursuant to our 2002 Employee Stock
Purchase Plan, or our 2002 ESPP, and up to 50,309 shares of our common stock
which may be offered from time to time by the selling stockholders identified on
page 110 of the Prospectus for their own accounts. Each of the selling
stockholders named in the Prospectus acquired the shares of common stock upon
exercise of options previously granted to them as an employee, director or
consultant of Ligand or as restricted stock granted to them as a director of
Ligand, in each case under the terms of our 2002 Plan. We will not receive any
of the proceeds from the sale of the shares of our common stock by the selling
stockholders under the Prospectus. We will receive proceeds in connection with
option exercises under the 2002 Plan and shares issued under the 2002 ESPP which
will be based upon each granted option exercise price or purchase price, as
applicable.

         This Prospectus Supplement No. 6 includes the attached Current Report
on Form 8-K of Ligand Pharmaceuticals Incorporated dated August 31, 2006, as
filed by us with the Securities and Exchange Commission.

         This Prospectus Supplement No. 6 should be read in conjunction with,
and delivered with, the Prospectus and is qualified by reference to the
Prospectus, except to the extent that the information in this Prospectus
Supplement No. 6 updates or supersedes the information contained in the
Prospectus.

         Our common stock is quoted on the Nasdaq Global Market under the symbol
"LGND." On August 30, 2006, the last reported sale price of our common stock on
the Nasdaq Global Market was $9.85 per share.

         INVESTING IN OUR COMMON STOCK INVOLVES RISK. SEE "RISK FACTORS"
BEGINNING ON PAGE 7 OF THE PROSPECTUS AND BEGINNING ON PAGE 52 OF PROSPECTUS
SUPPLEMENT NO. 5.

         Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved of these securities or determined if the
Prospectus or this Prospectus Supplement No. 6 is truthful or complete. Any
representation to the contrary is a criminal offense.

        The date of this Prospectus Supplement No. 6 is August 30, 2006.








                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                 ---------------



                                    FORM 8-K

                                 CURRENT REPORT




     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported): August 25, 2006

                       LIGAND PHARMACEUTICALS INCORPORATED
             (Exact name of registrant as specified in its charter)

                                    DELAWARE
                 (State or other jurisdiction of incorporation)

                                    000-20720
                            (Commission File Number)

                           10275 SCIENCE CENTER DRIVE,
                              SAN DIEGO, CALIFORNIA
                    (Address of principal executive offices)

       (858) 550-7500 (Registrant's telephone number, including area code)

                                   77-0160744
                      (I.R.S. Employer Identification No.)

                                   92121-1117
                                   (Zip Code)









ITEM 1.01. ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

CHAIRMAN AND CEO COMPENSATION

         On August 1, 2006, Ligand Pharmaceuticals Incorporated (the "Company")
announced the appointment of Henry F. Blissenbach as Chairman and interim Chief
Executive Officer. In connection with that appointment, the Company entered into
an agreement with Dr. Blissenbach regarding his compensation for serving in
those capacities, which included a monthly salary of $75,000, incentive
compensation of up to $100,000 based upon his performance of certain objectives
to be agreed upon and a special stock option grant to purchase 150,000 shares of
the Company's common stock. The Company also agreed to reimburse Dr. Blissenbach
for all reasonable expenses incurred in discharging his duties as interim Chief
Executive Officer.

         On August 25, 2006, upon review of additional facts and circumstances,
the Compensation Committee of the Company's Board of Directors (the
"Compensation Committee") approved, and the Company and Dr. Blissenbach agreed
to, modifications to his compensation package as follows, effective
retroactively to August 1, 2006:

o Base salary changed to $40,000 per month from $75,000 per month.
o Maximum bonus changed to $100,000 from $150,000.
o All other terms remain unchanged.

SEVERANCE AGREEMENTS

         On August 25, 2006, the Compensation Committee also approved and
ratified, and the Company has begun entering into additional severance
agreements with certain of its officers and executive officers as additional
retention incentives and to provide severance benefits to these officers that
are more closely equivalent to severance benefits already in place for other
executive officers.

         These additional agreements consist of a) change of control severance
agreements ("Change of Control Severance Agreements") and b) "ordinary"
severance agreements that apply regardless of a change of control ("Ordinary
Severance Agreements"). Each Change of Control Severance Agreement provides for
payment of certain benefits to the officer in the event his employment is
terminated without cause in connection with a change of control of the Company.
These benefits include one year of salary, plus the average bonus (if any) for
the prior two years, payment of health care premiums for one year and
acceleration of stock options. With certain exceptions, the officer must be
available for consulting services for one year and must abide by certain
restrictive covenants, including non-competition and non-solicitation of the
Company's employees. Each Ordinary Severance Agreement provides for payment of
six months salary in the event the officer's employment is terminated without
cause, regardless of a change of control.

         The Compensation Committee approved agreements for the following
officers and executive officers as shown below:

         Richard Bowen:             Ordinary Severance Agreement and Change of
                                    Control Severance Agreement
         Warner Broaddus:           Ordinary Severance Agreement
         Tod Mertes:                Ordinary Severance Agreement
         Matthew Witte:             Ordinary Severance Agreement and Change of
                                    Control Severance Agreement

         The foregoing descriptions of the severance agreements do not purport
to be complete and are qualified in their entirety by reference to such
agreements. A copy of a form of Change of Control Severance Agreement is filed
as Exhibit 10.1 hereto and a copy of a form of Ordinary Severance Agreement is
filed as Exhibit 10.2 hereto, each of which is incorporated by reference herein.



ITEM 9.01 FINANCIAL STATEMENTS AND EXHIBITS

(d)      Exhibits

EXHIBIT NUMBER             DESCRIPTION
--------------            -------------

10.1               Form of Letter Agreement (Change of Control
                   Severance Agreement) by and between the Company and certain
                   officers dated as of August 25, 2006

10.2               Form of Letter Agreement (Ordinary Severance Agreement)
                   by and between the Company and certain officers dated as of
                   August 25, 2006



                                   SIGNATURES
         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has caused this report to be signed on its behalf by the
undersigned.


                            LIGAND PHARMACEUTICALS INCORPORATED




  Date : August __, 2006    By:      /s/ Warner R. Broaddus
                            Name:    Warner R. Broaddus
                            Title:   Vice President, General Counsel & Secretary





                                                                    EXHIBIT 10.1


(Date)

(Name) (Address)

Dear __________:

                  The purpose of this letter agreement is to document the terms
of the severance package to which you will be entitled should your employment
with Ligand Pharmaceuticals Incorporated (the "Company") terminate under certain
specified circumstances.

                  Part One of this letter agreement sets forth certain
definitional provisions to be in effect for purposes of determining your benefit
entitlements. Part Two specifies the terms and conditions upon which you may
become entitled to receive severance benefits. Severance benefits accrue under
this letter agreement in the event your employment with the Company were to be
terminated involuntarily in connection with certain changes in control of the
Company. Part Three concludes this letter agreement with a series of general
terms and conditions applicable to your severance benefits.

                             PART ONE -- DEFINITIONS

                  DEFINITIONS. For purposes of this letter agreement, including
in particular the application of the special benefit limitations of Part Three,
the following definitions will be in effect:

    1.  Average Compensation means your average W-2 wages from the Company for
        the five (5) calendar years completed immediately prior to the calendar
        year in which the Change in Control is effected. Any W-2 wages for a
        partial year of employment will be annualized, in accordance with the
        frequency with which such wages are paid during such partial year,
        before inclusion within your Average Compensation.

    2.  Board means the Company's Board of Directors.

    3.  Change in Control means any of the following events:

               (i)    a merger or consolidation in which the Company is not the
         surviving entity, except for a transaction the principal purpose of
         which is to change the state in which the Company is incorporated,

              (ii)    the sale, transfer or other disposition of all or
         substantially all of the assets of the Company other than in the
         ordinary course of business,

             (iii)    any reverse merger in which the Company ceases to exist
         as an independent corporation and becomes the subsidiary of another
         corporation, except where there is an insubstantial change in the de
         facto voting control of the Company (e.g. the creation of a holding
         company),

              (iv)    any Hostile Take-Over,

               (v)    the acquisition by any person (or related group of
         persons), whether by tender or exchange offer made directly to the
         Company's stockholders, private purchases from one or more of the
         Company's stockholders, open market purchases or any other transaction,
         of beneficial



         ownership of securities possessing more than thirty
         percent (30%) of the total combined voting power of the Company's
         outstanding securities,

              (vi)    the acquisition by any person (or related group of
         persons), whether by tender or exchange offer made directly to the
         Company's stockholders, private purchases from one or more of the
         Company's stockholders, open market purchases or any other transaction,
         of additional securities of the Company which increase the total
         holdings of such person (or group) to a level of securities possessing
         more than fifty percent (50%) of the total combined voting power of the
         Company's outstanding securities, or

              (vii)   the acquisition by any person (or related group of
         persons), whether by tender or exchange offer made directly to the
         Company's stockholders, private purchases from one or more of the
         Company's stockholders, open market purchases or any other transaction,
         of securities of the Company possessing sufficient voting power in the
         aggregate to elect an absolute majority of the members of the Board
         (rounded up to the nearest whole number).

    4.   COBRA means the continuation-of-coverage provisions of the Consolidated
         Omnibus Budget Reconciliation Act of 1985, as amended.

    5.   Code means the Internal Revenue Code of 1986, as amended.

    6.   Common Stock means the Company's common stock, par value $0.001 per
         share.

    7.   Equity Incentive Plans means any of the following equity incentive
         plans of the Company: 1992 Stock Option/Stock Issuance Plan, the 2002
         Stock Incentive Plan, and the Restricted Stock Purchase Plan, together
         with any amendments or successors to such plans.

    8.   Equity Parachute Payment means, with respect to any Option (whether
         Acquisition-Accelerated or Severance-Accelerated) or unvested Stock
         Issuance, the portion deemed to be a parachute payment under Code
         Section 280G and the Treasury Regulations issued thereunder. Such
         Equity Parachute Payment shall be calculated in accordance with the
         valuation provisions established under Code Section 280G and the
         applicable Treasury Regulations and will include an appropriate dollar
         adjustment to reflect the lapse of your obligation to remain in the
         Company's employ as a condition to your vesting in the accelerated
         portion of such Option or Stock Issuance.

    9.   ERISA means the Employee Retirement Income Security Act of 1974, as
         amended.

   10.   Health Care Coverage means the health care benefits provided by the
         Company to you and your eligible dependents for which you are eligible
         to continue coverage under the provisions of COBRA.

   11.   Hostile Take-Over means either of the following events:

               (i)    the acquisition by any person (or related group of
         persons) whether by tender or exchange offer made directly to the
         Company's stockholders, private purchases from one or more of the
         Company's stockholders, open market purchases or any other transaction,
         of beneficial ownership of securities possessing more than thirty
         percent (30%) of the total combined voting power of the Company's
         outstanding securities pursuant to a tender offer made directly to the
         Company's stockholders which the Board does not recommend such
         stockholders to accept, or

              (ii)    a change in the composition of the Board over a period of
         thirty-six (36) consecutive months or less such that a majority of the
         Board members (rounded up to the next whole number) ceases, by reason
         of one or more contested elections for Board membership, to be
         comprised of individuals who either (a) have been Board members
         continuously since the beginning of such period or (b) have been
         elected or nominated for election as Board members during such period
         by at least a majority of the Board members described in clause (a) who
         were still in office at the time such election or nomination was
         approved by the Board.



   12.   Involuntary Termination means the termination of your employment with
         the Company:

              (i)     upon your involuntary discharge or dismissal, or

              (ii)    upon your resignation in connection with any of the
         following changes to the terms and conditions of your employment: (A) a
         change in your position with the Company which materially reduces your
         level of responsibility, (B) a greater than ten percent (10%) reduction
         in your level of compensation (including base salary, fringe benefits
         and participation in non-discretionary bonus programs under which
         awards are payable pursuant to objective financial or performance
         standards, but excluding equity compensation) or (C) a relocation of
         your principal place of employment by more than fifty (50) miles.

                      The following guidelines shall determine whether one or
         more reductions in compensation should be taken into account for
         purposes of clause (ii)(B):

              (a)     Any reduction in compensation which occurs in connection
                      with an across-the-board reduction in the level of
                      compensation payable to the Company's executive officers
                      or senior management shall not constitute grounds for a
                      clause(ii)(B) resignation, unless implemented within
                      eighteen(18)months after a Change in Control.

              (b)     In the event of a Hostile Take-Over, the greater than ten
                      percent (10%) standard of clause (ii)(B) shall be reduced
                      to zero percent (0%) so that any reduction in the level of
                      your compensation shall constitute grounds for a clause
                      (ii)(B)resignation.

                      In no event shall an Involuntary Termination be deemed to
         occur should your employment terminate by reason of death or permanent
         disability.

   13.   Option means any option granted to you under any of the Equity
         Incentive Plans which is outstanding at the time of your Involuntary
         Termination or any earlier Change in Control. Your outstanding options
         are to be divided into two separate categories as follows:

               (i) Acquisition-Accelerated Options: any outstanding Option (or
         installment thereof) which accelerates upon a Change in Control in
         accordance with the automatic acceleration provisions of the Equity
         Incentive Plans.

              (ii) Severance-Accelerated Options: any outstanding Option (or
         installment thereof) which is not an Acquisition-Accelerated Option but
         which accelerates upon your Involuntary Termination, whether or not in
         connection with a Change in Control, as part of your severance benefits
         under this letter agreement.

   14.   Other Parachute Payments mean any payments in the nature of
         compensation to which you may become entitled under this letter
         agreement (other than the Equity Parachute Payment) or any other
         arrangement with the Company, to the extent such payments qualify as
         parachute payments within the meaning of Code Section 280G(b)(2) and
         the Treasury Regulations issued thereunder or would so qualify if the
         aggregate present value of such payments exceeded the amount specified
         in Code Section 280G(b)(2)(ii).

   15.   Stock Issuance means the issuance of unvested shares of Common Stock
         under the Company's Restricted Stock Plan or any other Equity Incentive
         Plan.

   16.   Termination for Cause means an Involuntary Termination or resignation
         of your employment with the Company by reason of your conviction of any
         felony or other criminal act, your commission of any act of fraud or
         embezzlement, your unauthorized use or disclosure of confidential or
         proprietary information or trade secrets of the Company or its
         subsidiaries, or any other intentional misconduct on your part which
         adversely affects the business or affairs of the Company in a material
         manner.



                  PART TWO -- INVOLUNTARY TERMINATION BENEFITS


                You will be entitled to receive the severance benefits
specified below should there occur an Involuntary Termination of your employment
during the term of this letter agreement effected in connection with a Change in
Control, other than a Termination for Cause. However, in the absence of a
Hostile Take-Over, these benefits will continue to be paid you only for so long
as you remain available for any consulting services required of you under Part
Two, Paragraph 4 and abide by the restrictive covenants set forth in Part Two,
Paragraph 5.

    1.   Severance Payments.  You will receive severance payments from the
         Company for a period of twelve (12)months following your Involuntary
         Termination in an aggregate amount equal to the sum of (A) one (1)
         times the annual rate of base salary in effect for you at the time of
         your Involuntary Termination or at the time of the relevant Change in
         Control, whichever is higher plus (B) one (1) times the average of
         the bonuses (excluding any signing bonus) paid to you for services
         rendered in the two (2) fiscal years immediately preceding the fiscal
         year of your Involuntary Termination (annualized if paid for a partial
         fiscal year).  If a bonus is paid to you for only one of those years,
         then the bonus amount under Clause (B) will be equal to one (1) times
         such bonus amount.  The aggregate severance payments shall be paid to
         you in equal installments over the twelve-month period in accordance
         with the Company's normal payroll practices and subject to all
         applicable withholding taxes.  The severance payments will immediately
         terminate if and only if (i) you should cease to remain available for
         the consulting services required of you under Section 4, or (ii) you
         fail to abide by the restrictive covenants set forth in Section 5 .
         However, in the event your Involuntary Termination occurs in connection
         with a Hostile Take-Over, your severance payments will be paid to you
         in the form of a single lump sum amount within thirty (30) days after
         such Involuntary Termination, and the provisions of Sections 4 and 5 of
         this Part Two will not apply.

    2.   Health Care Coverage.  The Company will, at its expense, make any COBRA
         payments for you and your eligible dependents in order to continue your
         Health Care Coverage  until the earlier of (i) twelve (12)months after
         the effective date of your Involuntary Termination (other than a
         Termination for Cause) or (ii) the first date that you are covered
         under another employer's (or, in the event of rehire, the Company's)
         health benefit program which provides substantially the same level of
         benefits without exclusion for pre-existing medical conditions.  Such
         payments will be in lieu of any other continued health care coverage to
         which you or your dependents would otherwise be entitled pursuant to
         the requirements of Code Section 4980B by reason of your termination of
         employment.

    3.   Option Acceleration and Lapse of Restrictions.  Each of your
         outstanding Options under the Equity Incentive Plans will (to the
         extent not then otherwise exercisable) automatically accelerate so that
         each such Option will become immediately exercisable for the total
         number of shares of Common Stock at the time subject to that Option.
         Each such accelerated Option, together with all of your other vested
         Options, will remain exercisable for a period of twelve (12) months
         following your Involuntary Termination until the end of the specified
         ten (10)-year option term. Such Option(s) may be exercised for any or
         all of the option shares in accordance with the exercise provisions of
         the option agreement evidencing the grant.  In addition, all
         restrictions applicable to the Stock Issuances you hold (to the
         extent those restrictions have not previously lapsed in accordance with
         the terms of the issuance agreements) will automatically lapse upon
         your Involuntary Termination (except a Termination for Cause).

    4.   Consulting Services. Unless your Involuntary Termination occurs in
         connection with a Hostile Take-Over, you will make yourself available
         to perform consulting services reasonably requested of you during the
         twelve (12)-month period following your Involuntary Termination. You
         will be compensated at an hourly rate to be agreed upon by you and the
         Company at the time such consulting services are to be rendered, and
         you will be reimbursed for all reasonable out-of-pocket expenses
         incurred in rendering such services upon your submission of appropriate
         documentation for those expenses.

    5.   Restrictive Covenants. For the one hundred twenty (120)-day period
         following your Involuntary Termination:




                  (i)You will not directly or indirectly, whether for your own
           account or as an employee, director, consultant or advisor, provide
           services to any business enterprise which is at the time in
           competition with any of the Company's then existing or formally
           planned product lines and which is located geographically in an area
           where the Company maintains substantial business activities, unless
           you obtain the prior written consent of the Board of Directors.

           (ii) You will not directly or indirectly encourage or solicit any
           individual to leave the Company's employ for any reason or interfere
           in any other manner with the employment relationships at the time
           existing between the Company and its current or prospective
           employees.

           (iii) You will not induce or attempt to induce any customer,
           supplier, distributor, licensee or other business relation of the
           Company to cease doing business with the Company or in any way
           interfere with the existing business relationship between any such
           customer, supplier, distributor, licensee or other business relation
           and the Company.

         You acknowledge that monetary damages may not be sufficient to
         compensate the Company for any economic loss which may be incurred by
         reason of your breach of the foregoing restrictive covenants.
         Accordingly, in the event of any such breach, the Company shall, in
         addition to the cessation of the severance benefits provided you under
         this letter agreement and any remedies available to the Company at law,
         be entitled to obtain equitable relief in the form of an injunction
         precluding you from continuing to engage in such breach.

         None of the foregoing restrictive covenants in this section 5 shall be
         applicable in the event your Involuntary Termination occurs in
         connection with a Hostile Take-Over.

    6.   Benefit Reduction.

           (i) BENEFIT REDUCTION. If the Change in Control does not constitute a
           Hostile Take-Over, first the dollar amount of your severance payment
           under Paragraph 1 will be reduced to the extent necessary to assure
           that the present value of those benefits will not, when added to the
           present value of your Equity Parachute Payment and your Other
           Parachute Payments, exceed 2.99 times your Average Compensation. In
           the event of a Hostile Take-Over, no reduction will be made to your
           severance payment (or any other benefit to which you become entitled
           hereunder), unless necessary to provide you with the maximum
           after-tax benefit available, after taking into account any parachute
           excise tax which might otherwise be payable by you under Code Section
           4999 and any analogous State income tax provision.

           (ii) RESOLUTION OF DISPUTES. In the event there is any disagreement
           between you and the Company as to whether one or more benefits to
           which you become entitled (whether under this letter agreement or
           otherwise) in connection with a Change in Control constitute Equity
           Parachute Payments or Other Parachute Payments, such dispute is to be
           resolved as follows:

                A.      The matter shall be submitted for resolution to
           independent counsel mutually acceptable to you and the Company
           ("Independent Counsel"). The resolution reached by Independent
           Counsel shall be final and controlling. However, should the
           Independent Counsel determine that the status of the benefits in
           dispute can be resolved by obtaining a private letter ruling from the
           Internal Revenue Service, a formal and proper request for such ruling
           shall be prepared and submitted by Independent Counsel, and the
           determination made by the Internal Revenue Service in the issued
           ruling shall be controlling. All expenses incurred in connection with
           the retention of Independent Counsel and (if applicable) the
           preparation and submission of the ruling request shall be paid by the
           Company.

                B.      The present value of each Equity Parachute Payment and
           each of the Other Parachute Payments (including your severance
           payment and Health Care Coverage) shall be determined in accordance
           with the provisions of Code Section 280G(d)(4) and the Treasury
           Regulations issued thereunder.




           The full amount of your severance benefit under Paragraph 1 shall not
           be paid to you until any amounts in dispute under this Paragraph
           6(ii) have been resolved in accordance herewith. However, any portion
           of such severance payment which would not otherwise exceed the
           benefit limitation of Paragraph 6(i) even if all amounts in dispute
           under this Paragraph 6(ii) were to be resolved against you will be
           paid to you in accordance with the applicable provisions of this
           letter agreement.

           (iii) OVERRIDING LIMITATION. You will in all events be entitled to
           receive the full amount of your severance payment under Paragraph 1,
           to the extent those benefits, when added to the present value of your
           Equity Parachute Payment and your Other Parachute Payments (excluding
           such severance payment), will nevertheless qualify as reasonable
           compensation within the standards established under Code Section
           280G(b)(4).

           (iv) INTERPRETATION. The provisions of this Section 6 shall in all
           events be interpreted in such manner as will avoid the imposition of
           excise taxes under Code Section 4999, and the disallowance of
           deductions under Code Section 280G(a), with respect to your severance
           benefits under this letter agreement.

                     PART THREE -- MISCELLANEOUS PROVISIONS

    1.   Termination for Cause. Should your termination constitute a Termination
         for Cause, then the Company shall only be required to pay you (i) any
         unpaid compensation earned for services previously rendered through the
         date of such termination and (ii) any accrued but unpaid vacation
         benefits or sick days, (iii) any reimbursements then owed to you by the
         Company and no benefits will be payable to you under this letter
         agreement.

    2.   Term of Agreement. The provisions of this letter agreement will
         continue in effect for a period of five (5) years from the date hereof.

    3.   General Creditor Status. The benefits to which you may become entitled
         under this letter agreement (except those attributable to your Options
         or Stock Issuances) will be paid, when due, from the general assets of
         the Company. Your right (or the right of the executors or
         administrators of your estate) to receive any such payments will at all
         times be that of a general creditor of the Company and will have no
         priority over the claims of other general creditors of the Company.

    4.   Death. Should you die before receipt of all benefits to which you
         become entitled under this letter agreement, then the payment of such
         benefits will be made, on the due date or dates hereunder had you
         survived, to the executors or administrators of your estate. Should you
         die before you exercise your Severance-Accelerated Options (if any) or
         any other of your outstanding vested Options, then each such Option may
         be exercised, during the applicable exercise period in effect hereunder
         for those options at the time of your death, by the executors or
         administrators of your estate or by person to whom the Option is
         transferred pursuant to your will or in accordance with the laws of
         inheritance.

    5.   Miscellaneous.  The provisions of this letter agreement will be
         construed and interpreted under ERISA. To the extent ERISA is
         inapplicable, then the laws of the State of California shall control,
         without regard to that state's choice of law provisions.  This letter
         agreement incorporates the entire agreement between you and the Company
         relating to the subject of severance benefits and supersedes all prior
         agreements and understandings with respect to such subject matter.
         This letter agreement may only be amended by written instrument signed
         by you and another duly-authorized officer of the Company.  If any
         provision of this letter agreement as applied to any party or to any
         circumstance should be adjudged by an arbitrator or court of competent
         jurisdiction to be void or unenforceable for any reason, the invalidity
         of that provision shall in no way affect (to the maximum extent
         permissible by law) the application of such provision under
         circumstances different from those so adjudicated, the application
         of any other provision of this letter agreement, or the enforceability
         or invalidity of this letter agreement as a whole.  Should any
         provision of this letter agreement become or be determined to be
         invalid, illegal or unenforceable in any jurisdiction by reason of the
         scope, extent or duration of its coverage, then such provision shall be
         deemed amended to the extent necessary to conform to applicable
         law so as to be valid and enforceable or, if such provision cannot be
         so amended without materially altering the intention of the parties,
         then such provision shall be stricken



         and the remainder of this letter agreement shall continue in full force
         and effect.

    6.   Remedies. All rights and remedies provided pursuant to this letter
         agreement or by law will be cumulative, and no such right or remedy
         will be exclusive of any other. A party may pursue any one or more
         rights or remedies hereunder or may seek damages or specific
         performance in the event of another party's breach hereunder or may
         pursue any other remedy by law or equity, whether or not stated in this
         letter agreement.

    7.   Arbitration. Any controversy which may arise between you and the
         Company with respect to the construction, interpretation or application
         of any of the terms, provisions or conditions of this letter agreement
         or any monetary claim arising from or relating to this letter agreement
         will be submitted to and exclusively decided by final and binding
         arbitration in San Diego, California in accordance with the rules of
         the American Arbitration Association then in effect.

    8.   No Employment or Service Contract. Nothing in this letter agreement
         shall confer upon you any right to continue in the employment of the
         Company for any period of specific duration or interfere with or
         otherwise restrict in any way the rights of the Company or you, which
         rights are hereby expressly reserved by each, to terminate your
         employment at any time for any reason whatsoever, with or without
         cause.

    9.   Proprietary Information. You hereby acknowledge that the Company may,
         from time to time during your employment with the Company, disclose to
         you confidential information pertaining to the Company's business and
         affairs. All information and data, whether or not in writing, of a
         private or confidential nature concerning the business or financial
         affairs of the Company is and will remain subject to a separate
         Proprietary Information and Inventions Agreement (or the like) between
         you and the Company.


                  Please indicate your acceptance of the foregoing provisions of
  this severance agreement by signing the enclosed copy of this letter agreement
  and returning it to the Company.

  Very truly yours,

  LIGAND PHARMACEUTICALS INCORPORATED



  Henry F. Blissenbach
  Chairman and interim Chief Executive Officer

  HFB:bjo

  ACCEPTED BY AND AGREED TO



  Signature:      ___________________________________


  Dated: ___________________________________



                                                                    EXHIBIT 10.2


                               [Ligand Letterhead]

[Date]

[Insert Name and Address of Employee]


Dear ______________:

         The purpose of this letter agreement is to document the terms of
severance to which you will be entitled should your employment with Ligand
Pharmaceuticals Incorporated (the "Company") terminate without cause (whether or
not in connection with a change in control of the Company).

         Specifically, in the event your employment with the Company is
terminated without cause, you will be entitled severance payable in a lump sum,
equal to six months of your base salary. Payment of the severance is subject to
your signing and not revoking an effective general release of claims against the
Company and its subsidiaries. You will not be entitled to any severance if you
voluntarily leave the Company, or you are terminated for cause. Of course, in
addition to the severance you will be entitled to any accrued but unpaid salary,
unused vacation or sick days and all reimbursements then owed to you by the
Company.

         For purposes of this agreement, "cause" means termination of employment
due to: (i) conviction of any felony or other criminal act, (ii) commission of
any act of fraud or embezzlement, (iii) unauthorized use or disclosure of
confidential or proprietary information or trade secrets of the Company or its
subsidiaries, or (iv) any other intentional misconduct on your part which
adversely affects the business or affairs of the Company in a material manner.

         Your cash severance will be paid in a lump sum on the 8th day after you
sign and have not revoked the required general release.

         All severance paid will be less any required tax and other
withholdings.

         If you are entitled to receive any payments or benefits from the
Company pursuant to the requirements of the Worker Adjustment and Retraining
Notification Act and/or any similar federal, state or local law (collectively
referred to as "WARN laws") then the amount of severance payable under this
agreement shall be reduced by any and all such payments made by the Company. If
you are entitled to receive notice of termination from the Company pursuant to
WARN laws, then the severance payable under this agreement shall be reduced by
an amount equal to the amount of salary paid during the notice period provided
by the Company.

         This letter does not confer upon you any right to continue in the
employment of the Company for any period or interfere with or otherwise restrict
in any way the rights of the Company or you to terminate your employment at any
time for any reason whatsoever, with or without cause.

         This agreement does not interfere with, replace or otherwise impact any
other written agreements that you may have with the Company regarding retention,
severance or termination of employment in connection with a change in control of
the Company. This agreement does merge and incorporate any and all discussions,
understandings and other agreements regarding the subject matter hereof.

         Please indicate your acceptance of the provisions of this severance
agreement by signing the enclosed copy of this letter agreement and returning it
to the Company.

                                            Very truly yours,



                                            Ligand Pharmaceuticals Incorporated
Agreed and Accepted.



[Name]

Date