SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                ----------------

                                  SCHEDULE 13G
                                 (Rule 13d-102)
                                ----------------

    INFORMATION TO BE INCLUDED IN STATEMENTS PURSUANT TO RULES 13d-1(b), (c)
             AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2
                   UNDER THE SECURITIES EXCHANGE ACT OF 1934
                         (Amendment No. _____________)*


                      Ligand Pharmaceuticals Incorporated
                                (Name of Issuer)

                         Common Stock, $.001 par value
                         (Title of Class of Securities)

                                   53220K207
                                 (CUSIP Number)

                               February 28, 2006
            (Date of Event Which Requires Filing of this Statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
     [ ]  Rule 13d-1(b)
     [X]  Rule 13d-1(c)
     [ ]  Rule 13d-1(d)

-----------

     * The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.


     The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).





CUSIP No. 53220K207               13G                           Page 2 of 10

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     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          OZ Management, L.L.C.
-----------------------------------------------------------------------------
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a)  [ ]
                                                                    (b)  [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
               Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    4,076,040
SHARES
               -------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    0
OWNED BY       _____________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    4,076,040
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    0
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
          4,076,040
-----------------------------------------------------------------------------
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
          5.5%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
          IA
-----------------------------------------------------------------------------







CUSIP No. 53220K207               13G                           Page 3 of 10

-----------------------------------------------------------------------------
     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          Daniel S. Och
-----------------------------------------------------------------------------
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a)  [ ]
                                                                    (b)  [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
               United States
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    4,076,040
SHARES
               -------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    0
OWNED BY       _____________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    4,076,040
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    0
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
          4,076,040
-----------------------------------------------------------------------------
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
          5.5%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
          IN
-----------------------------------------------------------------------------





CUSIP No. 53220K207               13G                           Page 4 of 10

-----------------------------------------------------------------------------
     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          OZ Master Fund, Ltd.
-----------------------------------------------------------------------------
     (2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [ ]
                                                                    (b) [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
          Cayman Islands
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    3,830,500
SHARES
                -------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    0
OWNED BY
                -------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    3,830,500
REPORTING
                -------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    0

-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
          3,830,500
-----------------------------------------------------------------------------
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
          5.2%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
          CO
-----------------------------------------------------------------------------




CUSIP No. 53220K207               13G                           Page 5 of 10

ITEM 1(a).  NAME OF ISSUER:
            Ligand Pharmaceuticals Incorporated

ITEM 1(b).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
            10275 Science Center Drive, San Diego, CA 92121-1117

ITEMS 2(a), 2(b) and 2(c).   NAME OF PERSON FILING, ADDRESS OF PRINCIPAL
BUSINESS OFFICE AND CITIZENSHIP:

     This statement is filed by the entities and persons listed below, all of
whom together are referred to herein as the "Reporting Persons":

          (i) OZ Management, L.L.C. ("OZ"), a Delaware limited liability
              company, with respect to the Shares reported in this Schedule 13G
              held by certain investment funds and discretionary accounts
              managed by OZ (the "Accounts").

         (ii) Daniel S. Och, who is the Senior Managing Member of OZ,
              with respect to the Shares reported in this Schedule 13G
              held by the Accounts.

        (iii) OZ Master Fund, Ltd. ("OZMD"), a Cayman Islands company, with
              respect to shares owned by it.

          The citizenship of OZ and OZMD is set forth above. Daniel S. Och is a
United States citizen.

          The address of the principal business office of each of the Reporting
Persons is 9 West 57th Street, 39th Floor, New York, NY 10019. The address of
the principal business office of OZMD is c/o Goldman Sachs (Cayman) Trust,
Limited, P.O. Box 896, G.T. Harbour Centre, Second Floor, North Church Street,
George Town, Grand Cayman, Cayman Islands.





CUSIP No. 53220K207               13G                           Page 6 of 10

ITEM 2(d).  TITLE OF CLASS OF SECURITIES: Common Stock, $.001 par value

ITEM 2(e).  CUSIP NUMBER:      53220K207

ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO 13d-1(b) OR 13d-2(b) OR (c),
CHECK WHETHER THE PERSON FILING IS A:

          (a)  [ ] Broker or dealer registered under Section 15 of the Act;

          (b)  [ ] Bank as defined in Section 3(a)(6) of the Act;

          (c)  [ ] Insurance Company as defined in Section 3(a)(19) of the
                   Act;

          (d)  [ ] Investment Company registered under Section 8 of the
                   Investment Company Act of 1940;

          (e)  [ ] Investment Adviser registered under Section 203 of the
                   Investment Advisers Act of 1940: see Rule 13d-
                   1(b)(1)(ii)(E);

          (f)  [ ] Employee Benefit Plan, Pension Fund which is subject to
                   the provisions of the Employee Retirement Income Security
                   Act of 1974 or Endowment Fund; see Rule 13d- 1(b)(1)(ii)(F);

          (g)  [ ] Parent Holding Company, in accordance with Rule 13d-
                   1(b)(ii)(G);

          (h)  [ ] Savings Associations as defined in Section 3(b) of the
                   Federal Deposit Insurance Act;

          (i)  [ ] Church Plan that is excluded from the definition of an
                   investment company under Section 3(c)(14) of the Investment
                   Company Act of 1940; or

          (j)  [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

         IF THIS STATEMENT IS FILED PURSUANT TO Rule 13d-1(c), CHECK THIS
BOX. [x]





CUSIP No. 53220K207               13G                           Page 7 of 10

ITEM 4.   OWNERSHIP.

           OZ serves as principal investment manager to a number of investment
funds and discretionary accounts with respect to which it has voting and
dispositive authority over the Shares reported in this Schedule 13G. Mr. Daniel
S. Och is the Senior Managing Member of OZ. As such, he may be deemed to control
such entity and therefore may be deemed to be the beneficial owner of the Shares
reported in this Schedule 13G.

          Each of the Reporting Persons hereby disclaims any beneficial
ownership of any such Shares.

         A. OZ
           (a) Amount beneficially owned: 4,076,040
           (b) Percent of class: 5.5%
               (All percentages herein are based on 74,131,283 shares of
               Common Stock reported to be outstanding as of November 30, 2005,
               as reflected in the Form 10-Q filed by the Company on
               December 9, 2005 for the quarterly period ended
               September 30, 2005.)
           (c) Number of shares as to which such person has:
               (i) sole power to vote or to direct the vote  4,076,040
              (ii) shared power to vote or to direct the vote 0
             (iii) sole power to dispose or to direct the disposition of
                   4,076,040
              (iv) shared power to dispose or to direct the disposition of
                   0

         B. Daniel S. Och
           (a) Amount beneficially owned: 4,076,040
           (b) Percent of class: 5.5%
           (c) Number of shares as to which such person has:
               (i) sole power to vote or to direct the vote 4,076,040
              (ii) shared power to vote or to direct the vote 0
             (iii) sole power to dispose or to direct the disposition
                   4,076,040
              (iv) shared power to dispose or to direct the disposition of
                   0

         C. OZMD
           (a) Amount beneficially owned: 3,830,500
           (b) Percent of class: 5.2%
           (c) Number of shares as to which such person has:
               (i) sole power to vote or to direct the vote 3,830,500
              (ii) shared power to vote or to direct the vote 0
             (iii) sole power to dispose or to direct the disposition of
                   3,830,500
              (iv) shared power to dispose or to direct the disposition of
                   0





CUSIP No. 53220K207               13G                           Page 8 of 10

ITEM 5.   OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.
            Not applicable.

ITEM 6.   OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.
          See Item 4.

ITEM 7.   IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
          THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.
          Not applicable.

ITEM 8.   IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.
          See Item 4.

ITEM 9.   NOTICE OF DISSOLUTION OF GROUP.
          Not applicable.

ITEM 10.  CERTIFICATION.  (if filing pursuant to Rule 13d-1(c))

          Each of the Reporting Persons hereby makes the following
certification:

          By signing below each Reporting Person certifies that, to the best of
its knowledge and belief, the securities referred to above were not acquired and
are not held for the purpose of or with the effect of changing or influencing
the control of the issuer of the securities and were not acquired and not held
in connection with or as a participant in any transaction having that purpose or
effect.







CUSIP No. 53220K207               13G                           Page 9 of 10

                                   SIGNATURES

      After reasonable inquiry and to the best of our knowledge and belief, the
undersigned certify that the information set forth in this statement is true,
complete and correct.

DATED:  March 10, 2006              /s/ Daniel S. Och
                                    -----------------------------------
                                    OZ MANAGEMENT, L.L.C.
                                    By Daniel S. Och
                                    Senior Managing Member


                                    /s/ Daniel S. Och
                                    -----------------------------------
                                    Daniel S. Och

                                    /s/ Daniel S. Och
                                    -----------------------------------
                                    OZ MASTER FUND, LTD.
                                    By Daniel S. Och
                                    Director





CUSIP No. 53220K207               13G                           Page 10 of 10


                                    EXHIBIT 1

                           JOINT ACQUISITION STATEMENT
                            PURSUANT TO RULE 13d-1(k)


           The undersigned acknowledge and agree that the foregoing statement on
Schedule 13G, is filed on behalf of each of the undersigned and that all
subsequent amendments to this statement on Schedule 13G, shall be filed on
behalf of each of the undersigned without the necessity of filing additional
joint acquisition statements. The undersigned acknowledge that each shall be
responsible for the timely filing of such amendments, and for the completeness
and accuracy of the information concerning him or it contained therein, but
shall not be responsible for the completeness and accuracy of the information
concerning the others, except to the extent that he or it knows or has reason to
believe that such information is inaccurate.


DATED:  March 10, 2006              /s/ Daniel S. Och
                                    -----------------------------------
                                    OZ MANAGEMENT, L.L.C.
                                    By Daniel S. Och
                                    Senior Managing Member


                                    /s/ Daniel S. Och
                                    -----------------------------------
                                    Daniel S. Och


                                    /s/ Daniel S. Och
                                    -----------------------------------
                                    OZ MASTER FUND, LTD.
                                    By Daniel S. Och
                                    Director