As filed with the Securities and Exchange Commission on January 4, 2005
                                                     Registration No. 333-121406
--------------------------------------------------------------------------------
                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    
                                 AMENDMENT NO. 1
                                   FORM S-3/A
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
                                    
                                 CRYOLIFE, INC.
             (Exact name of registrant as specified in its charter)
                                    


                                                                     
                             FLORIDA                                                 59-2417093
  (State or other jurisdiction of incorporation or organization)        (I.R.S. Employer Identification No.)


                                 CRYOLIFE, INC.
                           1655 ROBERTS BOULEVARD, NW
                             KENNESAW, GEORGIA 30144
                                 (770) 419-3355
    (Address, including zip code, and telephone number, including area code,
                  of registrant's principal executive offices)
                      -----------------------------------


                                                                     
                                                                                 COPIES TO:
      STEVEN G. ANDERSON, PRESIDENT, CHIEF EXECUTIVE OFFICER            T. CLARK FITZGERALD III, ESQ.
              AND CHAIRMAN OF THE BOARD OF DIRECTORS                      ARNALL GOLDEN GREGORY LLP
                          CRYOLIFE, INC.                                       171 17TH STREET
                    1655 ROBERTS BOULEVARD, NW                                   SUITE 2100
                     KENNESAW, GEORGIA 30144                               ATLANTA, GEORGIA 30363
                          (770) 419-3355                                       (404) 873-8500


      (Name, address, including zip code, and telephone number,
             including area code, of agent for service)
                      -----------------------------------


     Approximate Date of Commencement of Proposed Sale to the Public:  FROM TIME
TO TIME AFTER THE EFFECTIVE DATE OF THIS REGISTRATION STATEMENT.

     If any of the securities being registered on this Form are to be offered on
a delayed or continuous  basis  pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. [ X ]

     If this Form is filed to  register  additional  securities  for an offering
pursuant to Rule 462(b) under the  Securities  Act,  check the following box and
list the Securities Act registration  statement number of the earlier  effective
registration statement for the same offering. [ ]

     If this Form is a  post-effective  amendment  filed pursuant to Rule 462(c)
under the  Securities  Act,  check the following box and list the Securities Act
registration  statement number of the earlier effective  registration  statement
for the same offering. [ ]

     If this Form is a  post-effective  amendment  filed pursuant to Rule 462(d)
under the  Securities  Act,  check the following box and list the Securities Act
registration  statement number of the earlier effective  registration  statement
for the same offering. [ ]

     If delivery of the  prospectus is expected to be made pursuant to Rule 434,
please check the following box. [ ]


     THE REGISTRANT  HEREBY AMENDS THIS  REGISTRATION  STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER  AMENDMENT  WHICH  SPECIFICALLY  STATES  THAT  THIS  REGISTRATION
STATEMENT SHALL  THEREAFTER  BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OR UNTIL THIS  REGISTRATION  STATEMENT SHALL BECOME EFFECTIVE
ON SUCH DATE AS THE SECURITIES AND EXCHANGE COMMISSION,  ACTING PURSUANT TO SAID
SECTION 8(A), MAY DETERMINE.
--------------------------------------------------------------------------------






                                     PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS


ITEM 14.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

     All  expenses,  other than fees and expenses of legal or other  advisors to
the  selling  shareholders,  will be  paid by  CryoLife.  Such  expenses  are as
follows:*

         SEC registration fee................................  $         5,885
         NYSE listing fee....................................           25,000
         Printing expenses...................................           10,000
         Accounting fees and expenses........................           25,000
         Legal fees and expenses.............................           50,000
         Miscellaneous.......................................           15,115
                                                               -----------------
                  Total......................................  $       131,000
                                                               =================

_____________________________
*The amounts set forth, except for the filing fees for the SEC, are estimated.


ITEM 15.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

     The Registrant is a Florida corporation. The following summary is qualified
in its  entirety by  reference  to the  complete  text of the  Florida  Business
Corporation   Act  (the  "FBCA"),   the   Registrant's   Restated   Articles  of
Incorporation,  the  Registrant's  Bylaws  and  the  indemnification  agreements
entered into with the Registrant's directors and Chief Financial Officer.

     Under Section  607.0850(1) of the FBCA, a corporation  may indemnify any of
its  directors  and  officers  against  expenses  (including  attorneys'  fees),
judgments, fines and amounts paid in settlement actually and reasonably incurred
by such person in connection with such action, suit or proceeding (including any
appeal thereof) (i) if such person acted in good faith and in a manner he or she
reasonably  believed  to be in, or not  opposed  to, the best  interests  of the
corporation,  and (ii) with respect to any criminal action or proceeding,  he or
she had no  reasonable  cause to believe  his or her conduct  was  unlawful.  In
actions  brought  by or in  the  right  of  the  corporation,  however,  Section
607.0850(2)  provides  that no  indemnification  shall be made in respect of any
claim,  issue or matter as to which the  director  or  officer  shall  have been
adjudged to be liable  unless,  and only to the extent that,  the court in which
such proceeding was brought, or any other court of competent jurisdiction, shall
determine upon  application  that,  despite the adjudication of liability but in
view of all  circumstances  of the case,  such  person is fairly and  reasonably
entitled to  indemnity  for such  expenses  which such court shall deem  proper.
Article X of the Registrant's  Restated Articles of Incorporation and Article VI
of the  Registrant's  Bylaws require that, if in the judgment of the majority of
the  Board of  Directors  (excluding  from  such  majority  any  director  under
consideration for indemnification) the criteria set forth under Section 607.0850
have been met, then the  Registrant  shall  indemnify its directors and officers
for certain liabilities incurred in the performance of their duties on behalf of
the  Registrant to the maximum  extent  allowed by Section  607.0850 of the FBCA
(formerly Section 607.014 of the Florida General Corporation Act).

     The  Registrant  has  purchased  insurance  to insure (i) the  Registrant's
directors and officers  against  damages from actions and claims incurred in the
course of their duties,  and (ii) the Registrant  against  expenses  incurred in
defending  lawsuits  arising from  certain  alleged  acts of its  directors  and
officers.

     The Registrant has entered into indemnification agreements with each of its
directors  and  its  Chief  Financial  Officer  ("Indemnitees"),  on  the  dates
indicated on Exhibit 99.1.  Pursuant to such  agreements,  the Registrant  shall
indemnify each Indemnitee  whenever he or she is or was a party or is threatened
to be made a party to any  proceeding,  including  without  limitation  any such
proceeding brought by or in the right of the Registrant, because he or she is or
was a director or officers of the Registrant


                                      II-1


or is or was serving at the request of the  Registrant  as a director or officer
of another corporation,  partnership,  joint venture, trust or other enterprise,
or because of  anything  done or not done by the  Indemnitee  in such  capacity,
against  expenses and  liabilities  (including  the costs of any  investigation,
defense,   settlement  or  appeal)  actually  and  reasonably  incurred  by  the
Indemnitee or on his or her behalf in connection with such proceeding,  if he or
she acted in good faith and in a manner he or she  reasonably  believed to be in
or not opposed to the best interests of the Registrant, and, with respect to any
criminal  action or  proceeding,  had no reasonable  cause to believe his or her
conduct  was  unlawful.  The  termination  of any action suit or  proceeding  by
judgment,  order, settlement,  conviction,  or upon a plea of nolo contendere or
its equivalent,  shall not, of itself,  create a presumption  that an Indemnitee
did not act in good faith and in a manner which he or she reasonably believed to
be in or not opposed to the best interests of the Registrant,  and, with respect
to any criminal action or proceeding,  had reasonable  cause to believe that his
or her  conduct  was  unlawful.  Unless a  determination  has been made that the
Indemnitee is not entitled to  indemnification  pursuant to the  agreement,  all
reasonable  expenses  incurred  by or on  behalf  of such  Indemnitee  shall  be
advanced  from time to time by the  Registrant to the  Indemnitee  within thirty
(30) days after the Registrant's  receipt of a written request for an advance of
expenses by such  Indemnitee,  whether prior to or after final  disposition of a
proceeding.  If required by law,  Indemnitee  shall  agree,  at the time of such
advance,  to repay the amounts  advanced  if it is  ultimately  determined  that
Indemnitee is not entitled to be  indemnified  under the terms of the agreement.
Any advances made shall be unsecured and no interest shall be charged thereon.


     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 (the "1933 Act"),  may be permitted  to  directors,  officers or persons
controlling the Registrant  pursuant to the foregoing  provisions of the Georgia
Business  Corporation  Code and the Registrant's  articles of incorporation  and
bylaws,  the Registrant has been informed that  indemnification is considered by
the Commission to be against public policy and therefore unenforceable.

ITEM 16.  EXHIBITS

Exhibit No.    Exhibit
----------     -------

3.1            Restated Certificate of Incorporation of the Company, as amended.
               (Incorporated  by  reference  to Exhibit 3.1 to the  Registrant's
               Quarterly  Report on Form 10-Q for the  quarter  ended  March 31,
               2003.)

3.2            Bylaws of the Company, as amended.  (Incorporated by reference to
               Exhibit 3.2 to the Registrant's Report on Form 8-K filed November
               8, 2004.)

3.3            Articles  of  Amendment  to  the  Articles  of  Incorporation  of
               CryoLife.  (Incorporated  by  reference  to  Exhibit  3.3  to the
               Registrant's  Annual  Report  on Form  10-K  for the  year  ended
               December 31, 2000.)

4.1            Form of Certificate for the Company's Common Stock. (Incorporated
               by  reference  to Exhibit  4.1 to the  Registrant's  Registration
               Statement on Form S-1 (Commission File No. 33-56388). )

4.2            Form of Certificate for the Company's Common Stock. (Incorporated
               by reference to Exhibit 4.2 to the Registrant's  Annual Report on
               Form 10-K for the year ended December 31, 1997.)

4.3            Rights   Agreement   between  the  Company  and  Chemical  Mellon
               Shareholder  Services,  L.L.C.,  as  Rights  Agent,  dated  as of
               November 27, 1995. (Incorporated by reference to Exhibit 10.36 to
               the  Registrant's  Annual Report on Form 10-K for the fiscal year
               ended December 31, 2000.)

4.4            First  Amendment  to Rights  Agreement,  effective  June 1, 1997,
               executed  by the  Company  and  American  Stock  Transfer & Trust
               Company, as successor Rights Agent. (Incorporated by reference to
               the Registrant's  Registration  Statement on Form S-3 (Commission
               File No. 333-112673.))

4.5+           Form of Depositary Agreement.

4.6+           Form of Depositary Receipt.

5.1*           Opinion of Arnall Golden  Gregory LLP  regarding  legality of the
               common stock and preferred stock.



                                      II-2


5.2*           Opinion of Arnall Golden  Gregory LLP  regarding  legality of the
               depositary shares.

12.1*          Computation of Ratio of Earnings to Fixed Charges

23.1*          Consent of Arnall Golden Gregory LLP (included as part of Exhibit
               5 hereto).

23.2*          Consent of Deloitte & Touche LLP.

23.3*          Notice regarding consent of Arthur Andersen LLP.

24.1           Power of Attorney (included in the signature pages of the initial
               filing of this registration statement).

99.1**         Form  of  Indemnification   Agreement  for  Directors  and  Chief
               Financial Officer of the Registrant.

_____________________________
* Previously filed.
**Filed herewith.
+ To be filed by amendment  or as an exhibit to a current  report on Form 8-K of
  the Registrant.

ITEM 17.  UNDERTAKINGS

     The undersigned registrant hereby undertakes:

     (1) To file,  during any period in which  offers or sales are being made, a
post-effective amendment to this registration statement:

          (i)  To include any  prospectus  required  by section  10(a)(3) of the
               Securities Act of 1933;

          (ii) To reflect in the  prospectus  any facts or events  arising after
               the  effective  date of the  registration  statement (or the most
               recent post-effective  amendment thereof) which,  individually or
               in  the  aggregate,   represent  a  fundamental   change  in  the
               information   set   forth   in   the   registration    statement.
               Notwithstanding the foregoing, any increase or decrease in volume
               of  securities  offered (if the total dollar value of  securities
               offered  would not  exceed  that  which was  registered)  and any
               deviation  from  the low or  high  end of the  estimated  maximum
               offering  range may be reflected in the form of prospectus  filed
               with the Commission pursuant to Rule 424(b) if, in the aggregate,
               the  changes  in volume  and price  represent  no more than a 20%
               change in the maximum  aggregate  offering price set forth in the
               "Calculation  of   Registration   Fee"  table  in  the  effective
               registration statement; and

          (iii)To include any material  information  with respect to the plan of
               distribution   not  previously   disclosed  in  the  registration
               statement  or any  material  change  to such  information  in the
               registration statement.

provided,   however,  that  paragraphs  (1)(i)  and  (1)(ii)  do  not  apply  if
information  required  to be  included in a  post-effective  amendment  by those
paragraphs  is contained in periodic  reports filed by  registrants  pursuant to
section  13 or  section  15(d) of the  Exchange  Act that  are  incorporated  by
reference in the registration statement.

     (2) That, for the purpose of determining any liability under the Securities
Act of 1933,  each  such  post-effective  amendment  shall be deemed to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

     (3) To remove from registration by means of a post-effective  amendment any
of the securities being registered which remain unsold at the termination of the
offering.


                                      II-3



     (4) That, for purposes of determining liability under the Securities Act of
1933, each filing of the registrant's annual report pursuant to section 13(a) or
section 15(d) of the  Securities  Exchange Act of 1934 (and,  where  applicable,
each filing of an employee  benefit  plan's  annual  report  pursuant to section
15(d) of the Securities  Exchange Act of 1934) that is incorporated by reference
in the registration statement shall be deemed to be a new registration statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

     (5) Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors,  officers and controlling  persons of
the  registrant  pursuant  to  the  foregoing  provisions,   or  otherwise,  the
registrant  has been advised that in the opinion of the  Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore,  unenforceable. In the event that a claim for indemnification
against such  liabilities  (other than the payment by the registrant of expenses
incurred or paid by a director,  officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director,  officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.



                                      II-4



                                   SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1933, the Registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-3 and has  duly  caused  this  Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Kennesaw, State of Georgia on January 4, 2005.

                                         CRYOLIFE, INC.

                                         By:  /s/ Steven G. Anderson
                                            ------------------------------------
                                         Steven G. Anderson
                                         President, Chief Executive Officer and 
                                         Chairman of the Board of Directors

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.

PRINCIPAL EXECUTIVE, FINANCIAL & ACCOUNTING OFFICERS AND DIRECTORS:
------------------------------------------------------------------



                                                                                     
    Name                                                          Title                               Date
    ----                                                          ------                              ----
/s/ Steven G. Anderson                            President, Chief Executive Officer and   January 4, 2005
-----------------------------------------         Chairman of the Board of Directors
Steven G. Anderson                                (Principal Executive Officer)

/s/ D. Ashley Lee                                 Executive Vice President, Chief          January 4, 2005
-----------------------------------------         Operating Officer and Chief Financial
D. Ashley Lee                                     Officer (Principal Financial and
                                                  Accounting Officer)

         *                                        Director                                 January 4, 2005
-----------------------------------------
Thomas F. Ackerman

         *                                        Director                                 January 4, 2005
-----------------------------------------
Dan Bevevino

         *                                        Director                                 January 4, 2005
-----------------------------------------
John M. Cook

         *                                        Director                                 January 4, 2005
-----------------------------------------
Ronald Charles Elkins, M.D.

         *                                        Director                                 January 4, 2005
-----------------------------------------
Virginia C. Lacy

         *                                        Director                                 January 4, 2005
-----------------------------------------
Ronald D. McCall

         *                                        Director                                 January 4, 2005
-----------------------------------------
Bruce J. Van Dyne, M.D.

*By: /s/ D. Ashley Lee
    -------------------------------------
      D. Ashley Lee, Attorney in Fact




                                      II-5




                                  EXHIBIT INDEX


Exhibit No.    Exhibit
----------     -------

3.1            Restated Certificate of Incorporation of the Company, as amended.
               (Incorporated  by  reference  to Exhibit 3.1 to the  Registrant's
               Quarterly  Report on Form 10-Q for the  quarter  ended  March 31,
               2003.)

3.2            Bylaws of the Company, as amended.  (Incorporated by reference to
               Exhibit 3.2 to the Registrant's Report on Form 8-K filed November
               8, 2004.)

3.3            Articles  of  Amendment  to  the  Articles  of  Incorporation  of
               CryoLife.  (Incorporated  by  reference  to  Exhibit  3.3  to the
               Registrant's  Annual  Report  on Form  10-K  for the  year  ended
               December 31, 2000.)

4.1            Form of Certificate for the Company's Common Stock. (Incorporated
               by  reference  to Exhibit  4.1 to the  Registrant's  Registration
               Statement on Form S-1 (Commission File No. 33-56388). )

4.2            Form of Certificate for the Company's Common Stock. (Incorporated
               by reference to Exhibit 4.2 to the Registrant's  Annual Report on
               Form 10-K for the year ended December 31, 1997.)

4.3            Rights   Agreement   between  the  Company  and  Chemical  Mellon
               Shareholder  Services,  L.L.C.,  as  Rights  Agent,  dated  as of
               November 27, 1995. (Incorporated by reference to Exhibit 10.36 to
               the  Registrant's  Annual Report on Form 10-K for the fiscal year
               ended December 31, 2000.)

4.4            First  Amendment  to Rights  Agreement,  effective  June 1, 1997,
               executed  by the  Company  and  American  Stock  Transfer & Trust
               Company, as successor Rights Agent. (Incorporated by reference to
               the Registrant's  Registration  Statement on Form S-3 (Commission
               File No. 333-112673.))

4.5+           Form of Depositary Agreement.

4.6+           Form of Depositary Receipt.

5.1*           Opinion of Arnall Golden  Gregory LLP  regarding  legality of the
               common stock and preferred stock.

5.2*           Opinion of Arnall Golden  Gregory LLP  regarding  legality of the
               depositary shares.

12.1*          Computation of Ratio of Earnings to Fixed Charges

23.1*          Consent of Arnall Golden Gregory LLP (included as part of Exhibit
               5 hereto).

23.2*          Consent of Deloitte & Touche LLP.

23.3*          Notice regarding consent of Arthur Andersen LLP.

24.1           Power of Attorney (included in the signature pages of the initial
               filing of this registration statement).

99.1**         Form  of  Indemnification   Agreement  for  Directors  and  Chief
               Financial Officer of the Registrant.

_____________________________
* Previously filed.
**Filed herewith.
+ To be filed by amendment  or as an exhibit to a current  report on Form 8-K of
  the Registrant.