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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                        --------------------------------

                                    FORM 8-K
                        --------------------------------


                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

       DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): February 22, 2006
                            -------------------------

                                 CRYOLIFE, INC.
             (Exact name of registrant as specified in its charter)
                            -------------------------


                                                    

----------------------------  --------------------------  ----------------------
       FLORIDA                     1-13165                      59-2417093
----------------------------  --------------------------  ----------------------

(State or Other Jurisdiction    (Commission File Number)      (IRS Employer
     of Incorporation)                                       Identification No.)
----------------------------  --------------------------  ----------------------
                                                                        

              1655 ROBERTS BOULEVARD, N.W., KENNESAW, GEORGIA 30144
               (Address of principal executive office) (zip code)

       REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE: (770) 419-3355

                                       N/A
          (Former name or former address, if changed since last report)

                                                       -------------------------

     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_| Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)

|_| Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)

|_| Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
Act (17 CFR 240.14d-2(b))

|_| Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))
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ITEM 2.02 RESULTS OF OPERATIONS AND FINANCIAL CONDITION

         The information provided pursuant to this Item 2.02 is to be considered
"filed"  under the  Securities  and  Exchange Act of 1934  ("Exchange  Act") and
incorporated by reference into those filings of CryoLife, Inc. ("CryoLife") that
provide for the  incorporation  of all reports and  documents  filed by CryoLife
under the Exchange Act.

         On February 22, 2006,  CryoLife  issued a press release  announcing its
financial  results for the quarter ended December 31, 2005 and fiscal year 2005.
CryoLife hereby  incorporates  by reference  herein the information set forth in
the press release dated February 22, 2006, a copy of which is attached hereto as
Exhibit 99.1

         Except as otherwise  provided in the press  release,  the press release
speaks  only as of its the date and shall not  create any  implication  that the
affairs of CryoLife have continued unchanged since that date.

         Except for the  historical  information  contained in this report,  the
statements  made by CryoLife are  forward-looking  statements that involve risks
and uncertainties. All such statements are subject to the safe harbor created by
the  Private  Securities  Litigation  Reform  Act  of  1995.  CryoLife's  future
financial  performance  could  differ  significantly  from the  expectations  of
management and from results expressed or implied in the press release.

         Please  refer to the last  paragraph  of the press  release for further
discussion about  forward-looking  statements.  For further  information on risk
factors,  please refer to "Risk Factors"  contained in CryoLife's  Form 10-K for
the year ended December 31, 2004, Form S-3  (Registration  No.  333-121406),  as
filed with the Securities and Exchange Commission ("SEC") and any subsequent SEC
filings.  CryoLife  disclaims  any  obligation or duty to update or modify these
forward-looking statements.



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ITEM 9.01  FINANCIAL STATEMENTS AND EXHIBITS.

     (a)  Financial Statements.
          Not  applicable.

     (b)  Pro Forma Financial Information.
          Not  applicable.

     (c)  Shell Company Transactions.
          Not  applicable.

     (d)  Exhibits.


Exhibit Number             Description

99.1                       Press Release dated February 22, 2006



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                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
CryoLife,  Inc.  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

Dated:  February 22, 2006               CryoLife, Inc.


                                        By: _/s/_D. Ashlee Lee__________________
                                        Name:  D. Ashley Lee
                                        Title: Executive Vice President,
                                               Chief Operating Officer and
                                               Chief Financial Officer


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                                  EXHIBIT INDEX


Exhibit Number    Description

99.1              Press Release dated February 22, 2006



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