UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 9)*



                         PROGENICS PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)



                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)



                                    743187106
--------------------------------------------------------------------------------
                                 (CUSIP Number)



                                December 31, 2007
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this  Schedule
is filed:

        [_]        Rule 13d-1(b)

        [_]        Rule 13d-1(c)

        [X]        Rule 13d-1(d)

* The  remainder  of this  cover  page  shall  be  filled  out for a  reporting
person's  initial  filing on this form with  respect  to the  subject  class of
securities,  and for any  subsequent  amendment  containing  information  which
would alter the disclosures provided in a prior cover page.

The  information  required  in the  remainder  of this  cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the  Securities  Exchange
Act of 1934 ("Act") or  otherwise  subject to the  liabilities  of that section
of the Act but shall be subject to all other  provisions  of the Act  (however,
see the Notes).



                                     Page 1



CUSIP No. 743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Investment Corporation
           ---------------------------------------------------------------------
                22-2514825
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization    Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power          2,107,881
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power     2,107,881
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned
           by Each Reporting Person                   2,107,881
                                                   -----------------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          7.1%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)     CO
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 2



CUSIP No. 743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Group Holdings LLC
           ---------------------------------------------------------------------
                13-3862746
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization    Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power            234,507
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power       234,507
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned
           by Each Reporting Person                     234,507
                                                   -----------------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          0.8%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)     OO
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 3



CUSIP No. 743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Paul Tudor Jones, II
           ---------------------------------------------------------------------

           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization    USA
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power              546,125
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power          2,342,388
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power         546,125
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power     2,342,388
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned
           by Each Reporting Person                   2,888,513
                                                   -----------------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          9.7%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)     IN
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 4



CUSIP No. 743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Mark F. Dalton
           ---------------------------------------------------------------------

           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization    USA
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power              159,000
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power          2,358,888
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power         159,000
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power     2,358,888
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned
           by Each Reporting Person                   2,517,888
                                                   -----------------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          8.5%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)     IN
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 5



CUSIP No. 743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

           The Tudor BVI Global Portfolio L.P. (f/k/a The Tudor BVI Global
           Portfolio Ltd.)
           ---------------------------------------------------------------------
                98-0223576
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization    Cayman Islands
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power          1,820,068
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power     1,820,068
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned
           by Each Reporting Person                   1,820,068
                                                   -----------------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          6.1%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)     PN
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 6



CUSIP No. 743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Arbitrage Partners L.P.
           ---------------------------------------------------------------------
                13-3496979
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization    Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power            193,126
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power       193,126
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned
           by Each Reporting Person                     193,126
                                                   -----------------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          0.6%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)     PN
                                                        ------------------------
--------------------------------------------------------------------------------



                                     Page 7



CUSIP No. 743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Proprietary Trading, L.L.C.
           ---------------------------------------------------------------------
                13-3720063
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization    Delaware
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power             25,981
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power        25,981
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned
           by Each Reporting Person                      25,981
                                                   -----------------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          0.1%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)     OO
                                                        ------------------------
--------------------------------------------------------------------------------


                                     Page 8



CUSIP No. 743187106
          -------------------

--------------------------------------------------------------------------------

     1)    Names of Reporting Person

           S.S. or I.R.S. Identification No. of Above Person

                Tudor Global Trading LLC
           ---------------------------------------------------------------------
                13-3862744
           ---------------------------------------------------------------------
--------------------------------------------------------------------------------

     2)    Check the Appropriate Box if a Member of a Group (See Instructions)
           (a)
               -----------------------------------------------------------------
           (b)    X
               -----------------------------------------------------------------
--------------------------------------------------------------------------------

     3)    SEC Use Only
                           -----------------------------------------------------
--------------------------------------------------------------------------------

     4)    Citizenship or Place of Organization    Cayman Islands
                                                --------------------------------
--------------------------------------------------------------------------------
                   (5)   Sole Voting Power                    0
                                            ------------------------------------
Number of Shares   -------------------------------------------------------------
Beneficially       (6)   Shared Voting Power            208,526
Owned by Each                                 ----------------------------------
Reporting Person   -------------------------------------------------------------
With               (7)   Sole Dispositive Power               0
                                                 -------------------------------
                   -------------------------------------------------------------
                   (8)   Shared Dispositive Power       208,526
                                                   -----------------------------
--------------------------------------------------------------------------------
     9)    Aggregate Amount Beneficially Owned
            by Each Reporting Person                    208,526
                                                   -----------------------------
--------------------------------------------------------------------------------
    10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares
           (See Instructions)
                              --------------------------------------------------
--------------------------------------------------------------------------------

    11)    Percent of Class Represented by Amount in Row 9          0.7%
                                                             -------------------
--------------------------------------------------------------------------------

    12)    Type of Reporting Person (See Instructions)     CO
                                                        ------------------------
--------------------------------------------------------------------------------




                                     Page 9


 Item 1(a). Name of Issuer:

            Progenics Pharmaceuticals, Inc.

Item 1(b).  Address of Issuer's Principal Executive Offices:

            777 Old Saw Mill River Road
            Tarrytown, NY 10591

Item 2(a).  Name of Person Filing:

            Tudor Investment Corporation ("TIC")
            Tudor Group Holdings LLC ("TGH")
            Paul Tudor Jones, II
            Mark F. Dalton
            The Tudor BVI  Global  Portfolio L.P.  (f/k/a  The Tudor BVI  Global
            Portfolio Ltd.) ("Tudor BVI")
            Tudor Arbitrage Partners L.P. ("TAP")
            Tudor Proprietary Trading, L.L.C. ("TPT")
            Tudor Global Trading LLC ("TGT")

Item 2(b).  Address of Principal Business Office or, if none, Residence:

            The principal business office of each of TIC, TGH, TAP, TPT and TGT
            is:

                1275 King Street
                Greenwich, CT 06831

            The principal  business  office of each of Messrs. Jones and Dalton
            is:

                c/o Tudor Investment Corporation
                1275 King Street
                Greenwich, CT 06831

            The principal business office of Tudor BVI is:

                c/o CITCO
                Kaya Flamboyan 9
                Curacao, Netherlands Antilles

Item 2(c).  Citizenship:

            TIC is a Delaware corporation
            Tudor BVI is a limited partnership  organized  under the laws of the
            Cayman Islands
            Messrs. Jones and Dalton are citizens of the United States
            TAP is a Delaware limited partnership
            TGH, TPT and TGT are Delaware limited liability companies



                                    Page 10


Item 2(d).  Title of Class of Securities:

            Common Stock

Item 2(e).  CUSIP Number:

            743187106

Item 3.     If this statement is filed pursuant to Rules 13d-1(b),  or 13d-2(b),
            check whether the person filing is a:

            (a) [ ] Broker or Dealer registered under Section 15 of the Act
            (b) [ ] Bank as defined in section 3(a)(6) of the Act
            (c) [ ] Insurance Company  as defined in Section 3(a)(19) of the Act
            (d) [ ] Investment  Company  registered   under  Section 8   of  the
                    Investment Company Act
            (e) [ ] Investment  Adviser  registered  under  section  203 of  the
                    Investment Advisers Act of 1940
            (f) [ ] Employment  Benefit Plan,  Pension Fund which  is subject to
                    the  provisions of the Employee  Retirement  Income Security
                    Act of 1974 or Endowment Fund; see ss.240.13d-1(b)(1)(ii)(F)
            (g) [ ] Parent    Holding    Company,     in     accordance     with
                    ss.240.13d-1(b)(1)(ii)(G) (Note:  See Item 7)
            (h) [ ] Group, in accordance with ss.240.13d-1(b)(1)(ii)(H)

Item 4.     Ownership (as of December 31, 2007).

            (a)  Amount Beneficially Owned:  See Item 9 of cover pages

            (b)  Percent of Class:  See Item 11 of cover pages

            (c)  Number of shares as to which such person has:

                 (i)    sole power to vote or to direct the vote     See  Item 5
                                                                  --------------
                                                                  of cover pages
                                                                  --------------

                 (ii)   shared power to vote or to direct the vote   See  Item 6
                                                                  --------------
                                                                  of cover pages
                                                                  --------------

                 (iii)  sole power to dispose or to direct the disposition of
                                                       See Item 7 of cover pages
                                                       -------------------------

                 (iv)   shared power to dispose or to direct the disposition  of
                                                       See Item 8 of cover pages
                                                       -------------------------

      The shares of common stock  ("Shares")  reported  herein as  beneficially
owned  are  owned  directly  by Tudor  BVI  (1,820,068  Shares),  TAP  (193,126
Shares), TPT (25,981 Shares), and TGT (15,400 Shares).

      Because TIC provides  investment  advisory services to Tudor BVI, TIC may
be deemed to  beneficially  own the Shares  owned by Tudor BVI.  TIC  expressly
disclaims  beneficial  ownership  of such  Shares.  TGH holds a majority of the
equity  interests  of TGT and  indirectly  holds a majority  of the  membership
interests  of  TPT.  TGH  is  also  the  sole  limited   partner  of  TAP.


                                  Page 11



     TGH expressly  disclaims  beneficial  ownership of the Shares  beneficially
owned by each of such entities.  TGT, as the sole general partner of TAP, may be
deemed to beneficially own the Shares owned by TAP, and Mr. Dalton,  as the sole
general partner of D.F. Partners, a New York limited partnership,  may be deemed
to beneficially own the Shares owned by such entity.  Each of TGT and Mr. Dalton
expressly  disclaim  beneficial  ownership  of such  Shares.  Mr.  Jones  is the
Chairman  and  principal  equity  owner  of TIC and  TGH.  Mr.  Jones  expressly
disclaims  beneficial  ownership  of the Shares  beneficially  owned,  or deemed
beneficially  owned,  by such  entities.  Mr.  Dalton is the Vice  Chairman  and
President  and an equity owner of TIC and TGH. Mr.  Dalton  expressly  disclaims
beneficial  ownership of the Shares  beneficially  owned, or deemed beneficially
owned, by such entities.

      The Shares  reported  herein under Items 5 and 7 of Mr. Jones' cover page
include  4,600  Shares  held  directly  by  Mr.  Jones'  individual  retirement
account.  The  Shares  reported  herein  under  Items  5 and 7 of Mr.  Dalton's
cover page include 85,000 immediately exercisable options.



Item 5.  Ownership of Five Percent or Less of a Class.

            Not applicable

Item 6.  Ownership of More than Five Percent on Behalf of Another Person.

            Not applicable

Item 7.  Identification  and  Classification  of the Subsidiary  Which Acquired
         the Security Being Reported on By the Parents Holding Company.

            Not applicable

Item 8.  Identification and Classification of Members of the Group.

            See cover pages

Item 9.  Notice of Dissolution of Group.

            Not applicable

Item 10. Certification.

            Not applicable


                                    Page 12


         After  reasonable  inquiry and to the best of my knowledge and belief,
I certify that the  information  set forth in this statement is true,  complete
and correct.


                               Dated:  February 13, 2008

                               TUDOR INVESTMENT CORPORATION


                               By:     /s/ Stephen N. Waldman
                                   --------------------------------------------
                                   Stephen N. Waldman
                                   Managing   Director  and  Associate  General
                                     Counsel

                               TUDOR GROUP HOLDINGS LLC


                               By:     /s/ Stephen N. Waldman
                                   --------------------------------------------
                                   Stephen N. Waldman
                                   Managing   Director  and  Associate  General
                                     Counsel



                                   /s/ Paul Tudor Jones, II
                               --------------------------------------------
                                   Paul Tudor Jones, II



                                   /s/ Mark F. Dalton
                               ------------------------------------------------
                                   Mark F. Dalton


                               THE TUDOR BVI GLOBAL PORTFOLIO L.P.

                               By: Tudor BVI GP Ltd.
                               Its:General Partner

                               By: Tudor Investment Corporation,
                                   Trading Advisor

                               By:     /s/ Stephen N. Waldman
                                   --------------------------------------------
                                   Stephen N. Waldman
                                   Managing   Director  and  Associate  General
                                     Counsel




                                    Page 13


                               TUDOR ARBITRAGE PARTNERS L.P.

                               By: Tudor Global Trading LLC,
                                   General Partner


                               By:     /s/ Stephen N. Waldman
                                   --------------------------------------------
                                   Stephen N. Waldman
                                   Managing   Director  and  Associate  General
                                     Counsel

                               TUDOR PROPRIETARY TRADING, L.L.C.


                               By:     /s/ Stephen N. Waldman
                                   --------------------------------------------
                                   Stephen N. Waldman
                                   Managing   Director  and  Associate  General
                                     Counsel

                               TUDOR GLOBAL TRADING LLC


                               By:     /s/ Stephen N. Waldman
                                   --------------------------------------------
                                   Stephen N. Waldman
                                   Managing   Director  and  Associate  General
                                     Counsel




                                    Page 14