þ
|
QUARTERLY
REPORT PURSUANT TO SECTION 13 OR 15(d) OF
THE
|
q
|
TRANSITION
REPORT PURSUANT TO SECTION 13 OR 15(d) OF
THE
|
Delaware
|
76-0474169
|
(State
or Other Jurisdiction of
Incorporation
or Organization)
|
(I.R.S.
Employer
Identification
Number)
|
Yes
|
ü
|
No
|
Yes
|
No
|
Yes
|
No
|
ü
|
Page
|
||
3
|
||
Item
1.
|
3
|
|
Consolidated Balance Sheets – September 30, 2009
(unaudited) and December 31, 2008
|
3
|
|
Consolidated Statements of Operations
(unaudited) – Three and Nine Months Ended September 30, 2009 and
2008
|
4
|
|
Consolidated Statements of Stockholders’ Equity
(unaudited) – Nine Months Ended September 30, 2009 and
2008
|
5
|
|
Consolidated Statements of Cash Flows (unaudited) –
Nine Months Ended September 30, 2009 and 2008
|
6
|
|
7
|
||
Item
2.
|
17
|
|
Item
3.
|
26
|
|
Item
4.
|
26
|
|
28
|
||
Item
1.
|
28
|
|
Item
1A.
|
28
|
|
Item
4.
|
31
|
|
Item
6.
|
31
|
|
32
|
||
As
of September 30,
|
As
of December 31,
|
|||||||
2009
|
2008
|
|||||||
Assets
|
(unaudited)
|
|||||||
Current
assets:
|
||||||||
Cash and cash
equivalents
|
$
|
62,736
|
$
|
85,873
|
||||
Short-term investments,
including restricted investments of $430
|
56,727
|
629
|
||||||
Short-term investments held by
Symphony Icon, Inc.
|
5,683
|
16,610
|
||||||
Accounts receivable, net of
allowances of $35
|
1,347
|
568
|
||||||
Prepaid expenses and other
current assets
|
7,217
|
5,487
|
||||||
Total current
assets
|
133,710
|
109,167
|
||||||
Long-term
investments
|
—
|
55,686
|
||||||
Property
and equipment, net of accumulated depreciation and amortization of $74,510
and $71,102, respectively
|
60,090
|
65,087
|
||||||
Goodwill
|
25,798
|
25,798
|
||||||
Other
assets
|
4,086
|
5,770
|
||||||
Total assets
|
$
|
223,684
|
$
|
261,508
|
||||
Liabilities
and Equity
|
||||||||
Current
liabilities:
|
||||||||
Accounts
payable
|
$
|
3,413
|
$
|
7,926
|
||||
Accrued
liabilities
|
6,812
|
6,615
|
||||||
Current portion of deferred
revenue
|
1,081
|
5,672
|
||||||
Current portion of long-term
debt
|
38,860
|
963
|
||||||
Total current
liabilities
|
50,166
|
21,176
|
||||||
Deferred
revenue, net of current portion
|
14,212
|
14,212
|
||||||
Long-term
debt
|
28,754
|
29,529
|
||||||
Other
long-term liabilities
|
653
|
764
|
||||||
Total
liabilities
|
93,785
|
65,681
|
||||||
Commitments
and contingencies
|
||||||||
Equity:
|
||||||||
Lexicon Pharmaceuticals, Inc.
stockholders’ equity:
|
||||||||
Preferred stock, $.01 par
value; 5,000 shares authorized; no shares issued and
outstanding
|
—
|
—
|
||||||
Common stock, $.001 par value;
900,000 and 300,000 shares authorized, respectively; 137,452 and 136,797
shares issued, respectively
|
137
|
137
|
||||||
Additional paid-in
capital
|
677,546
|
672,838
|
||||||
Accumulated
deficit
|
(548,170
|
)
|
(487,395
|
)
|
||||
Accumulated other
comprehensive loss
|
(1
|
)
|
—
|
|||||
Treasury stock at cost, 80 and
no shares, respectively
|
(88
|
)
|
—
|
|||||
Total Lexicon Pharmaceuticals,
Inc. stockholders’ equity
|
129,424
|
185,580
|
||||||
Noncontrolling interest in
Symphony Icon, Inc.
|
475
|
10,247
|
||||||
Total equity
|
129,899
|
195,827
|
||||||
Total liabilities and
equity
|
$
|
223,684
|
$
|
261,508
|
Three
Months Ended September 30,
|
Nine
Months Ended September 30,
|
|||||||||||||||
2009
|
2008
|
2009
|
2008
|
|||||||||||||
Revenues:
|
||||||||||||||||
Collaborative
research
|
$
|
1,650
|
$
|
7,202
|
$
|
8,042
|
$
|
22,789
|
||||||||
Subscription and license
fees
|
481
|
310
|
1,246
|
3,182
|
||||||||||||
Total
revenues
|
2,131
|
7,512
|
9,288
|
25,971
|
||||||||||||
Operating
expenses:
|
||||||||||||||||
Research
and development, including stock-based compensation of $733, $836, $2,328,
and $2,913, respectively
|
19,320
|
27,344
|
62,404
|
84,868
|
||||||||||||
General
and administrative, including stock-based compensation of $547, $583,
$1,750, and $1,868, respectively
|
4,568
|
4,990
|
14,993
|
16,749
|
||||||||||||
Total operating
expenses
|
23,888
|
32,334
|
77,397
|
101,617
|
||||||||||||
Loss
from operations
|
(21,757
|
)
|
(24,822
|
)
|
(68,109
|
)
|
(75,646
|
)
|
||||||||
Gain
(loss) on investments, net
|
185
|
(3,322
|
)
|
1,008
|
(3,322
|
)
|
||||||||||
Interest
income
|
103
|
956
|
669
|
5,155
|
||||||||||||
Interest
expense
|
(785
|
)
|
(675
|
)
|
(2,180
|
)
|
(2,020
|
)
|
||||||||
Other
expense, net
|
(516
|
)
|
(535
|
)
|
(2,037
|
)
|
(1,621
|
)
|
||||||||
Consolidated
net loss before taxes
|
(22,770
|
)
|
(28,398
|
)
|
(70,649
|
)
|
(77,454
|
)
|
||||||||
Income
tax benefit
|
102
|
—
|
102
|
—
|
||||||||||||
Consolidated
net loss
|
(22,668
|
)
|
(23,398
|
)
|
(70,547
|
)
|
(77,454
|
)
|
||||||||
Less:
Net loss attributable to noncontrolling interest in Symphony Icon,
Inc.
|
3,526
|
4,939
|
9,772
|
16,011
|
||||||||||||
Net
loss attributable to Lexicon Pharmaceuticals, Inc.
|
$
|
(19,142
|
)
|
$
|
(23,459
|
)
|
$
|
(60,775
|
)
|
$
|
(61,443
|
)
|
||||
Net
loss attributable to Lexicon Pharmaceuticals, Inc. per common share, basic
and diluted
|
$
|
(0.14
|
)
|
$
|
(0.17
|
)
|
$
|
(0.44
|
)
|
$
|
(0.45
|
)
|
||||
Shares
used in computing net loss attributable to Lexicon Pharmaceuticals, Inc.
per common share, basic and diluted
|
137,313
|
136,796
|
137,240
|
136,796
|
Lexicon
Pharmaceuticals, Inc. Stockholders
|
||||||||||||||||||||||||||||||||||||
Additional
Paid-In
Capital
|
Accumulated
Deficit
|
Accumulated
Other Comprehensive Loss
|
Treasury
Stock
|
Total
|
Noncontrolling
Interest
|
Total
Equity
|
||||||||||||||||||||||||||||||
Common
Stock
|
||||||||||||||||||||||||||||||||||||
Shares
|
Par
Value
|
|||||||||||||||||||||||||||||||||||
Balance
at December 31, 2007
|
136,796
|
$
|
137
|
$
|
666,702
|
$
|
(410,535
|
)
|
$
|
(4
|
)
|
$
|
—
|
$
|
256,300
|
$
|
30,271
|
$
|
286,571
|
|||||||||||||||||
Stock-based
compensation
|
—
|
—
|
4,781
|
—
|
—
|
—
|
4,781
|
—
|
4,781
|
|||||||||||||||||||||||||||
Exercise
of common stock options
|
—
|
—
|
1
|
—
|
—
|
—
|
1
|
—
|
1
|
|||||||||||||||||||||||||||
Net
loss
|
—
|
—
|
—
|
(61,443
|
)
|
—
|
—
|
(61,443
|
)
|
(16,011
|
)
|
(77,454
|
)
|
|||||||||||||||||||||||
Unrealized
loss on investments
|
—
|
—
|
—
|
—
|
42
|
—
|
42
|
—
|
42
|
|||||||||||||||||||||||||||
Comprehensive
loss
|
(61,401
|
)
|
(77,412
|
)
|
||||||||||||||||||||||||||||||||
Balance
at September 30, 2008
|
136,796
|
$
|
137
|
$
|
671,484
|
$
|
(471,978
|
)
|
$
|
38
|
$
|
—
|
$
|
199,681
|
$
|
14,260
|
$
|
213,941
|
||||||||||||||||||
Balance
at December 31, 2008
|
136,797
|
$
|
137
|
$
|
672,838
|
$
|
(487,395
|
)
|
$
|
—
|
$
|
—
|
$
|
185,580
|
$
|
10,247
|
$
|
195,827
|
||||||||||||||||||
Stock-based
compensation
|
—
|
—
|
4,443
|
—
|
—
|
—
|
4,443
|
—
|
4,443
|
|||||||||||||||||||||||||||
Grant
of restricted stock
|
534
|
—
|
—
|
—
|
—
|
—
|
—
|
—
|
—
|
|||||||||||||||||||||||||||
Exercise
of common stock options
|
121
|
—
|
265
|
—
|
—
|
—
|
265
|
—
|
265
|
|||||||||||||||||||||||||||
Repurchase
of common stock
|
—
|
—
|
—
|
—
|
—
|
(88
|
)
|
(88
|
)
|
—
|
(88
|
)
|
||||||||||||||||||||||||
Net
loss
|
—
|
—
|
—
|
(60,775
|
)
|
—
|
—
|
(60,775
|
)
|
(9,772
|
)
|
(70,547
|
)
|
|||||||||||||||||||||||
Unrealized
loss on investments
|
—
|
—
|
—
|
—
|
(1
|
)
|
—
|
(1
|
)
|
—
|
(1
|
)
|
||||||||||||||||||||||||
Comprehensive
loss
|
(60,776
|
)
|
(70,548
|
)
|
||||||||||||||||||||||||||||||||
Balance
at September 30, 2009
|
137,452
|
$
|
137
|
$
|
677,546
|
$
|
(548,170
|
)
|
$
|
(1
|
)
|
$
|
(88
|
)
|
$
|
129,424
|
$
|
475
|
$
|
129,899
|
Nine
Months Ended September 30,
|
||||||||
2009
|
2008
|
|||||||
Cash
flows from operating activities:
|
||||||||
Consolidated net
loss
|
$
|
(70,547
|
)
|
$
|
(77,454
|
)
|
||
Adjustments to reconcile
consolidated net loss to net cash used in operating
activities:
|
||||||||
Depreciation
|
4,760
|
6,057
|
||||||
Impairment of fixed
assets
|
445
|
—
|
||||||
Amortization of Symphony Icon,
Inc. purchase option
|
1,606
|
1,606
|
||||||
Stock-based
compensation
|
4,078
|
4,781
|
||||||
(Gain) loss on
investments
|
(2,396
|
)
|
3,322
|
|||||
Loss on ARS
Rights
|
1,388
|
—
|
||||||
Gain on disposal of property and
equipment
|
(15
|
)
|
—
|
|||||
Changes in operating assets and
liabilities:
|
||||||||
(Increase) decrease in
accounts receivable
|
(779
|
)
|
993
|
|||||
Increase in prepaid expenses
and other current assets
|
(1,730
|
)
|
(2,957
|
)
|
||||
Decrease in other
assets
|
78
|
55
|
||||||
Increase (decrease) in
accounts payable and other liabilities
|
(4,062
|
)
|
961
|
|||||
Decrease in deferred
revenue
|
(4,591
|
)
|
(13,274
|
)
|
||||
Net cash used in operating
activities
|
(71,765
|
)
|
(75,910
|
)
|
||||
Cash
flows from investing activities:
|
||||||||
Purchases of property and
equipment
|
(303
|
)
|
(1,672
|
)
|
||||
Proceeds from disposal of
property and equipment
|
110
|
—
|
||||||
Purchases of investments held
by Symphony Icon, Inc.
|
(1,500
|
)
|
—
|
|||||
Maturities of investments held
by Symphony Icon, Inc.
|
12,427
|
15,519
|
||||||
Purchases
of investments
|
(59,955
|
)
|
(39,847
|
)
|
||||
Maturities of
investments
|
60,550
|
179,830
|
||||||
Net cash provided by investing
activities
|
11,329
|
153,830
|
||||||
Cash
flows from financing activities:
|
||||||||
Proceeds from exercise of
stock options
|
265
|
1
|
||||||
Repurchase of common
stock
|
(88
|
)
|
—
|
|||||
Proceeds from debt
borrowings
|
38,592
|
—
|
||||||
Repayment of debt
borrowings
|
(1,470
|
)
|
(650
|
)
|
||||
Net cash provided by (used in)
financing activities
|
37,299
|
(649
|
)
|
|||||
Net
increase (decrease) in cash and cash equivalents
|
(23,137
|
)
|
77,271
|
|||||
Cash
and cash equivalents at beginning of period
|
85,873
|
22,938
|
||||||
Cash
and cash equivalents at end of period
|
$
|
62,736
|
$
|
100,209
|
||||
Supplemental
disclosure of cash flow information:
|
||||||||
Cash paid for
interest
|
$
|
1,897
|
$
|
1,962
|
||||
Supplemental
disclosure of non-cash investing and financing activities:
|
||||||||
Unrealized gain (loss) on
investments
|
$
|
(1
|
)
|
$
|
42
|
Expected
Volatility
|
Risk-free
Interest Rate
|
Expected
Term
|
Estimated
Forfeitures
|
Dividend
Rate
|
||||||||||||||||
September
30, 2009:
|
||||||||||||||||||||
Employees
|
78
|
%
|
1.9
|
%
|
5
|
24
|
%
|
0
|
%
|
|||||||||||
Officers
and non-employee directors
|
77
|
%
|
2.7
|
%
|
8
|
7
|
%
|
0
|
%
|
|||||||||||
September
30, 2008:
|
||||||||||||||||||||
Employees
|
66
|
%
|
2.9
|
%
|
6
|
22
|
%
|
0
|
%
|
|||||||||||
Officers
and non-employee directors
|
66
|
%
|
3.8
|
%
|
9
|
6
|
%
|
0
|
%
|
Options
|
Weighted
Average Exercise Price
|
||||||
(in
thousands)
|
|||||||
Outstanding
at December 31, 2008
|
16,898
|
$
|
5.13
|
||||
Granted
|
4,852
|
1.44
|
|||||
Exercised
|
(121
|
)
|
2.18
|
||||
Expired
|
(2,199
|
)
|
6.11
|
||||
Forfeited
|
(903
|
)
|
2.48
|
||||
Outstanding
at September 30, 2009
|
18,527
|
4.20
|
|||||
Exercisable
at September 30, 2009
|
11,212
|
$
|
5.70
|
Shares
|
Weighted
Average Grant Date
Fair
Value
|
||||||
(in
thousands)
|
|||||||
Outstanding
at December 31, 2008
|
—
|
$
|
—
|
||||
Granted
|
534
|
1.45
|
|||||
Vested
|
(267
|
)
|
1.45
|
||||
Forfeited
|
(12
|
)
|
1.45
|
||||
Nonvested
at September 30, 2009
|
255
|
$
|
1.45
|
As
of September 30, 2009
|
||||||||||||||||
Amortized
Cost
|
Gross
Unrealized Gains
|
Gross
Unrealized Losses
|
Estimated
Fair Value
|
|||||||||||||
(In
thousands)
|
||||||||||||||||
Cash
and cash equivalents
|
$
|
62,737
|
$
|
—
|
$
|
(1
|
)
|
$
|
62,736
|
|||||||
Securities
maturing within one year:
|
||||||||||||||||
Certificates
of deposit
|
508
|
—
|
—
|
508
|
||||||||||||
ARS
Rights
|
—
|
10,672
|
—
|
10,672
|
||||||||||||
Securities
maturing after ten years:
|
||||||||||||||||
Auction
rate securities
|
56,525
|
—
|
(10,978
|
)
|
45,547
|
|||||||||||
Total short-term
investments
|
$
|
57,033
|
$
|
10,672
|
$
|
(10,978
|
)
|
$
|
56,727
|
|||||||
Short-term
investments held by Symphony Icon, Inc.:
|
||||||||||||||||
Cash
and cash equivalents
|
5,683
|
—
|
—
|
5,683
|
||||||||||||
Total short-term investments
held by Symphony Icon, Inc.
|
$
|
5,683
|
$
|
—
|
$
|
—
|
$
|
5,683
|
||||||||
Total
cash and cash equivalents and investments
|
$
|
125,453
|
$
|
10,672
|
$
|
(10,979
|
)
|
$
|
125,146
|
As
of December 31, 2008
|
||||||||||||||||
Amortized
Cost
|
Gross
Unrealized Gains
|
Gross
Unrealized Losses
|
Estimated
Fair Value
|
|||||||||||||
(In
thousands)
|
||||||||||||||||
Cash
and cash equivalents
|
$
|
85,873
|
$
|
—
|
$
|
—
|
$
|
85,873
|
||||||||
Securities
maturing within one year:
|
||||||||||||||||
Certificates of
deposit
|
629
|
—
|
—
|
629
|
||||||||||||
Total short-term
investments
|
$
|
629
|
$
|
—
|
$
|
—
|
$
|
629
|
||||||||
Securities
maturing after one year through five years:
|
||||||||||||||||
ARS Rights
|
—
|
12,060
|
—
|
12,060
|
||||||||||||
Securities
maturing after ten years:
|
||||||||||||||||
Auction rate
securities
|
57,000
|
—
|
(13,374
|