UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940 |
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Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. | SEC 1473 (7-02) | ||
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. |
1. Title of Derivative Security (Instr. 4) |
2. Date Exercisable and Expiration Date (Month/Day/Year) |
3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) |
4. Conversion or Exercise Price of Derivative Security | 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5) |
6. Nature of Indirect Beneficial Ownership (Instr. 5) |
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Date Exercisable | Expiration Date | Title | Amount or Number of Shares | ||||
Warrant No. 86 | 01/24/2005 | 05/11/2009 | Common Stock | 500,000 (6) | $ 3.25 | I | See footnotes (1) (2) (3) |
Warrant No. 88 | 01/24/2005 | 03/22/2009 | Common Stock | 316,663 (6) | $ 3.25 | I | See footnotes (1) (2) (4) |
Warrant No. 89 | 01/24/2005 | 03/22/2009 | Common Stock | 25,014 (6) | $ 3.25 | I | See footnotes (1) (2) (5) |
Warrant No. 90 | 01/24/2005 | 05/11/2009 | Common Stock | 1,400 (6) | $ 3.25 | I | See footnotes (1) (2) (5) |
Warrant No. 91 | 01/24/2005 | 03/22/2009 | Common Stock | 339,600 (6) | $ 3.25 | I | See footnotes (1) (2) (5) |
Warrant No. 92 | 01/24/2005 | 05/11/2009 | Common Stock | 400,650 (6) | $ 3.25 | I | See footnotes (1) (2) (5) |
Reporting Owner Name / Address | Relationships | |||
Director | 10% Owner | Officer | Other | |
BVF PARTNERS L P/IL 227 WEST MONROE STREET SUITE 4800 CHICAGO, IL 60606 |
 |  X |  | Indirect Beneficial Owner |
BIOTECHNOLOGY VALUE FUND L P 227 WEST MONROE STREET SUITE 4800 CHICAGO, IL 60606 |
 |  X |  | See footnote (1) |
BIOTECHNOLOGY VALUE FUND II LP 227 WEST MONROE STREET SUITE 4800 CHICAGO, IL 60606 |
 |  X |  | See footnote (1) |
BVF INVESTMENTS LLC 227 WEST MONROE STREET SUITE 4800 CHICAGO, IL 60606 |
 |  X |  | See footnote (1) |
BVF INC/IL ONE SANSOME ST 31ST FLOOR SAN FRANCISCO, CA 94104 |
 |  X |  |  |
BVF Partners, L.P., By: BVF Inc., its GP, By: /s/ Mark N. Lampert, President | 02/01/2005 | |
**Signature of Reporting Person | Date | |
BIOTECHNOLOGY VALUE FUND, L.P., By: BVF Partners L.P., its GP, By: BVF Inc., its GP, By: /s/ Mark N. Lampert, President | 02/01/2005 | |
**Signature of Reporting Person | Date | |
BIOTECHNOLOGY VALUE FUND II, L.P., By: BVF Partners L.P., its GP, By: BVF Inc., its GP, By: /s/ Mark N. Lampert, President | 02/01/2005 | |
**Signature of Reporting Person | Date | |
BVF INVESTMENTS, L.L.C., By: BVF Partners L.P., its Manager, By: BVF Inc., its GP, By: /s/ Mark N. Lampert, President | 02/01/2005 | |
**Signature of Reporting Person | Date | |
BVF Inc., By: /s/ Mark N. Lampert, President | 02/01/2005 | |
**Signature of Reporting Person | Date |
* | If the form is filed by more than one reporting person, see Instruction 5(b)(v). |
** | Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). |
(1) | The shares of Common Stock, par value $0.001 per share, underlying the Warrants reported in this response are directly beneficially owned by Biotechnology Value Fund, L.P., a Delaware limited partnership ("BVF, L.P.") (500,000 shares); Biotechnology Value Fund II, L.P., a Delaware limited partnership ("BVF2, L.P.") (316,663 shares); BVF Investments, L.L.C., a Delaware limited liability company ("Investments") (766,664 shares); and indirectly beneficially owned by BVF Partners L.P., a Delaware limited partnership ("Partners"), and by its general partner ("GP") BVF Inc., a Delaware corporation ("BVF Inc."), which is also an investment advisor to Partners. Partners is the general partner of BVF, L.P. and BVF2, L.P., and is the manager of Investments. |
(2) | Pursuant to the operating agreement of Investments, Partners is authorized, among other things, to invest the funds of Ziff Asset Management, L.P., the majority member of Investments, in the equity securities described herein as being beneficially owned by Investments. Mark N. Lampert is the sole shareholder and sole director of BVF Inc., and is an officer of BVF Inc. This joint filing on Form 3 shall not be deemed an admission that Mark N. Lampert is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise, the beneficial owner of any equity securities covered by this joint filing. Mr. Lampert disclaims beneficial ownership of shares reported in this response, except to the extent that he has a pecuniary interest therein. |
(3) | Shares are directly beneficially owned by BVF, L.P. |
(4) | Shares are directly beneficially owned by BVF2, L.P. |
(5) | Shares are directly beneficially owned by Investments. |
(6) | The Warrants contain a cashless exercise provision. |